Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
28 Cards in this Set
- Front
- Back
|
role of alcohol & tobacco in head/neck cancers
|
both are risk factors, together they are synergistic
|
|
|
HPV status in head/neck
|
improved outcomes in HPV positive
|
|
|
surgery is the treatment of choice in all head/neck except
|
laryngeal- chemo + rad is equivalent to surgery and no organ damage
|
|
|
cetuximab + cisplatin effectiveness in head/neck
|
improved OR, no benefit in PFS or OS
|
|
|
cetuximab + RT effectiveness in head/neck
|
cetuximab is radiosensitizer --> improved PFS & OS vs RT alone
|
|
|
head/neck treatment of early stage disease
|
surgery or RT
|
|
|
head/neck treatment of locally advanced disease
|
surgery, then RT or chemo +RT if unresectable
|
|
|
std chemo induction regimen for head/neck
|
DCF- docetaxel improves OS
|
|
|
radiosensitizing chemo agents in head/neck
|
*cisplatin, also: 5FU, cetuximab, carbo, MMC, bleo, and paclitaxel
|
|
|
head/neck treatment for metastatic
|
single agent equivalent to combination for OS. Cisplatin + 5FU has higher response rate than single agent
|
|
|
metastatic head/neck use of cetuximab
|
cetuximab + combined chemo has survival benefits over combined chemo alone
|
|
|
most common cancers that metastisize to brain (2)
|
breast & lung
|
|
|
brain tumor more common in men & tumor more common in women
|
men= gliomas
women= meningiomas |
|
|
age glioblastomas occur
|
age 15 and increase above age 45
|
|
|
medulloblastoma and embryonal tumors rarely occur after age
|
20 yrs
|
|
|
intratumor chemical that predicts responsiveness to alkylating agents in CNS tumors
|
MGMT: increased levels result in resistance.
|
|
|
higher incidence of meningiomas in women with
|
breast cancer
|
|
|
chemo in meningioma
|
no benefit w/chemo. Surgical resection is curable if completely resected. DVT rate up to 72% post-op
|
|
|
most aggressive type of astrocytoma
|
glioblastoma multiforme
|
|
|
chemo is astrocytoma
|
no role. Surgery if possible, or RT
|
|
|
chemo role in anaplastic astrocytoma
|
adjuvant chemo has benefit with cytoreductive surgery or RT
|
|
|
chemo regimen in anaplastic astrocytoma
|
carmustine 200mg/m2 Q6wk or procarbazine, CCNU, vincristine
|
|
|
salvage treatment for anaplastic astrocytoma
|
temozolamide 150mg/m2/d for 5 days in 1st cycle followed by 200mg/m2/d for subsequent cycles. Cycle =28 days
|
|
|
addition of ___ to rad improves OS in GBM
|
temozolomide
|
|
|
temozolomide doses in GBM
|
75mg/m2 QD during RT and 150-200mg/m2/d x 5 days every 28 days x 6 cycles
|
|
|
add to temozolomide therapy with daily use + RT
|
PCP prophylaxis (Septra DS)
|
|
|
chemo for recurrent disease in GBM
|
irinotecan + bevacizumab
|
|
|
most active chemo agent in Primary Central Nervous System Lymphomas (PCNSL)
|
HD-MTX 3.5-8 g/m2 Q14d
|
