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160 Cards in this Set
- Front
- Back
5 layers of scalp
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S skin
C connective tissue (dense) A aponeurosis L loose connective tissue P pericranium |
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description of scalp layer 1
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skin: hair bearing with sweat and sebaceous glands
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clinical rep of scalp layer 1
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common infections of skin: sebaceous cysts that move freely with the scalp and don't invade underlying subcutaneous tissue
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description of scalp layer 2
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dense CT: subcutaneous layer of dense connective tissue; consists chiefly of collagen bundles with fat interspersed in between
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attachments in 2nd layer
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collagen fibers criss cross and attach to skin above and aponeurotic layer below
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what courses through 2nd layer of scalp?
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arteries, veins, and nerves course through the dense CT
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description of 3rd layer of scalp
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aponeurotic layer: musculo-aponeurotic helmet
aponeurotic part covers the dome and 2 pairs of muscle bellies located ant and post. |
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epicranius of 3rd layer of scalp:
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frontalis muscle and occipitalis muscle
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location of epicranius
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frontalis muscle: arises from aponeurotic part and attaches to skin and CT over eyebrows
occipitalis muscle: arises from superior nuchal line of occipital bone and mastoid part of temporal bone and inserts on the aponeurosis |
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nerve supply to epicranius
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branches of CNVII
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aponeurosis attaches to:
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post to the occipital bone and laterally attached to the zygomatic arch
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clinical rep of 3rd scalp layer
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aponeurosis: scalp wound which splits the aponeurosis in coronal plane produces a GAPING wound since fibers are directed ant/post in sagittal plane
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description of 4th scalp layer
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loose CT: forms cleavage plan between first 3 layers and 5th layer. accounts for mobility of the scalp on the skull.
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clinical rep of 4th layer of scalp
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danger plane: loose CT allows pus or fluid to spread rapidly and extensively being only limited by the attachments of the overlying aponeurotic layer----infections result in inflammation of emissary veins resulting in thrombophlebitis of the dural venous sinuses
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description of the 5th layer of the scalp
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pericranium: periosteum covering the outer lamina of skull bones; adheres weakly over bone surfaces, but firmly fixed at sutures where it connects to inner periosteum
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clinical rep of 5th layer of scalp
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because of firm attachment at sutures, in skull fractures collections of blood have a tendancy to outline the affected bone
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blood supply of scalp: what two sets of branches
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indirect branches of ICA and direct branches of ECA
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4 parts of ICA
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1) cervical ICA
2) petrous ICA 3) sigmoid or intercavernous ICA 4) supraclinoid ICA |
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where is the cervical part of the ICA?
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ascends the neck and gives off no branches in the neck; at base of skull cervical ICA enters the carotid canal in the petrous temporal bone.
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where is the petrous part of the ICA?
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when ICA enters carotid canal in the petrous temporal bone, it courses upward and then forward to the apex of the petrous temporal bone in the MCF.
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where is the sigmoid/intercavernous part of the ICA?
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the petrous ICA crosses the upper part fo the foramen lacerum (between petrous temporal bone and body of sphenoid) and enters cavernous sinus. this 3rd part has an S-shaped coarse within sinus, first ascending toward the posterior clinoid process and then turning fwd horizontally
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where is the supraclinoid part of the ICA?
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the supraclinoid ICA pierces the dura of the roof of the cavernous sinus medial to the ant clinoid process
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branches of supraclinoid ICA
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gives off terminal branches most of which supply the brain, but one branch, the ophthalmic artery enters the optic canal and courses to the orbit where it gives off numerous named branches, including the supratrochlear and supraorbital arteries
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Indirect branches of ICA: flow---->
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ICA ---> ophthalmic a. ---> supratrochlear a. and supraorbital a.
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direct branches of the ECA:
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numerous branches in the neck, 3 of which supply blood to the scalp: superficial temp a.
post. auricular a. occipital a. |
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superficial temporal a.
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direct branch of ECA; one of the two terminal branches of the ECA, supplies area in front of (ant) to the ear and superior to the ear (temple)
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posterior auricular a.
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direct branch of ECA:
area behind the ear |
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occipital a.
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direct branch of ECA: posterior aspect of the scalp
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clinical importance of blood supply to scalp:
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richest cutaneous blood supply in the body.
possible to reattach lg areas of scalp that become detached b/c of frequent anastomosis between terminal branches of scalp arteries |
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clinical impt. of blood supply to scalp: rel to collagen
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outer art walls of vessels attach to criss crossing collagen of 2nd layer so when lacerated, separated ends of arteries cannot retract to close, profuse bleeding occurs.....have to apply local pressure to compress severed ends.
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clinical impt of blood supply to scalp, rel to bones of skull
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art of scalp for most part do not supply bones of skull, so a scalp wound does not produce necrosis of the bony cranium
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nerve supply of scalp: (2 parts)
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CNV (3 div) and branches of cervical nerves (C2 and C3)
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nerve supply of scalp: V1
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V1: ophthalmic div: supratrochlear n. and supraorbital n.
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nerve supply of scalp: V2
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V2: maxillary div: zygomaticotemporal n. (temple)
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nerve supply of scalp: V3
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V3: mandibular div: auriculotemporal n.
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nerve supply of scalp: branches of cervical nerves
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a) lesser occipital n.: from cervical plexus, supplies skin behind and above the ear
b) great auricular n. c) greater occipital n.: is dorsal ramus of C2---supplies post portion of the scalp (medial to occipital a.) |
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what does the skull consist of?
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2 plates of compact bone: outer and inner laminae, with spongy bone in between (the diploe)
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Meninges: top of 3 layers
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dura mater: inelastic thick membrane, 2 layers not easily separated except sinuses
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2 types of dura: outer
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periosteal dura (also endosteal): outer rough texture; fuses with pericranium at sutures and skull foramina, and at FM
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blood supply to dura
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primary blood supply to dura is in periosteal layer: middle meningeal artery
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laceration of MMA produces what?
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epidural hematoma: rapidly expanding mass of blood accumulates between the periosteal dura and calvarium; may press on underlying primary motor area of brain
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sequence of clinical signs of an epidural hematoma:
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1) brief loss of consciousness
2) lucid interval of sev hrs 3) relapse into coma; contralateral motor paralysis of opp side of body |
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inner layer of dura
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meningeal layer: inner, smoothe texture. sends 4 partitions inward which divide the cranial cavity into 3 freely communicating compartments
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inner layer of dura is continuous with what
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con't with dura covering spinal cord and forms tubular sheaths for CN
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subdural space
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potential space between meningeal dura and underlying arachnoid membrane
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clinical rep of meningeal dura
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cerebral veins traverse meningeal dura to enter the SSS, tearing of these veins produces a subdural hematoma
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difference between subdural and epidural hematoma
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subdural: low pressure venous leakage, bet meningeal dura and arachnoid, symptoms occur slowly
epidural hematoma: arterial high pressure leakage, fast acting, may press on underlying cortex |
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middle layer of meninges
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arachnoid mater
avascular membrane, underlies the meningeal dura covers gyri, but does not dip into the sucli cobwebs |
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lower layer of meninges
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pia mater: dips into sulci, can't be readily peeled
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subarachnoid space SAS
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between arach and pia mater
contains CSF, arteries and veins of brain and SC pass through |
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clinical rep of SAS
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follows rupture of aneurysm of a cerebral vessel such as anterior, middle, or post cerebral arteries which traverse the SAS. MOST EXCRUCIATING HEADACHE OF MY LIFE
lumbar puncture shows blood in CSF |
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Dural partitions: 2 vertical and 2 horizontal
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Vertical: falx cerebri, falx cerebelli
horizontal: tentorium cerebelli and diaphragma sellae |
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Falx cerebri
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vertical partition of meningeal dura, occupies the logitudinal fissure; attaches ant to crista galli and crest of the frontal bone
inf border overlies the corpus callosum; posteriorly fuses with upper surface of the tentorium cerebelli |
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clinical note of falx cerebri
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when increased intracranial pressure occurs, sharp edges of falx cerebri can result in damage to the cingulate gyrus, located dorsal to corpus callosum
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falx cerebelli
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meningeal dura sep 2 cerebellar hemispheres; attached to internal occipital crest and to inf part of tent. cerebelli
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tentorium cerebelli
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tent shaped roof over posterior cranial fossa; separates occipital lobes from cerebellum
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fixed border of tent. cbl
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outer, attached to margins of the grooves for transverse sinuses on occip bone, to the crest of the petrous temp bone, and attaches anteriorly to post clinoid processes
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free border of tent cbl
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concave around midbrain and its 2 ends course fwd, cross the fixed part and attach to ant clinoid processes of sphenoid bone
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clinical note of tent cbl
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free border surrounds midbrain , just above is the medial aspect of temp bone (uncus). when intracranial pressure above tentorium is higher than below, the brain is displaced downward and the uncus may herniate through the free border of the tent cbl and be lacerated by taut edges. also inc pressure can cause part of cbl to herniate through FM
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diaphragma sellae
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forms roof over depression in the sella turcica for pit gland. central aperture in partition for the infundibular stalk to connect pit to hypothal
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definition of dural venous sinuses
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triangular, endothelial lined space formed between 2 layers of the dura
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outpocketings along the sides of some sinuses, chiefly from SSS
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venous lacunae
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function of dural venous sinuses
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act as collecting channels for drainage of blood from 4 sets of veins:
1) cerebral v.: drain brain hemispheres and upper brain stem 2) meningeal veins: drain meninges 3) diploic veins: drain bones of cranium 4) emissary veins: scalp and other head regions have veins outside skull that course through foramina in skull and drain into venous sinuses |
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arachnoid granulations
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cauliflower-like elevations of arachnoid project through the dura into SSS or its venous lacunae (lakes); CSF is diffused passively from subarachnoid space via arachnoid gran into DVS into internal jugular vein
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all dural venous sinuses communicate with each other and drain....
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either directly or indirectly into the internal jugular vein
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SSS occupies what and joins what
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occupies triangular interval between periosteal dura and diverging meningeal dural layers in fixed, convex border of falx cerebri; joins the right transverse sinus
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ISS situated where and unites with what
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situated between 2 layers of meningeal dura in the free inferior margin of the falx cerebri; unites posteriorly with the great vein of galen to form straight sinus
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straight sinus occupies and joins what
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occupies the line of junction between the falx cerebri posteriorly with the upper peaked portion of the tent cbl; joins the left transverse sinus
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transverse sinuses: begin and occupy where/what
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begin as continuations of the SSS and straight sinuses; ;occupy the peripheral attached circumference of the tent cbl up to the base of the peterous temp bone where join the sigmoid sinuses on each side
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sigmoid sinuses: where
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arch down from petrous temporal bone, groove the mastoid part of the temporal bone, and turn forward over the occipital bone to enter the jugular foramen; empty into the jugular bulb of internal jug veins in jug formaina
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superior petrosal sinuses located where and join what
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located in attachment of tentorium cbl to the superior margin of the petrous temp bone; join cavernous sinuses ant and sigmoid sinuses posteriorly
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cavernous sinuses situated where and formed between what
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situated on either side of the body of the sphenoid bone, lateral to the diaphragma sellae, formed between MD and PD
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cavernous sinus is unique why?
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each cavernous sinus has nerves:
Outer wall of sinus: CNIII, IV, V1, V2 in the sinus: CNVI and ICA with the VI nerve lateral and inferior to the ICA; each sinus drains into superior and inferior petrosal sinuses |
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sphenoparietal sinuses
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located along post border of the lesser wing of the sphenoid bone; drain into cavernous sinuses
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inferior petrosal sinuses
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lie in petro-occipital fissure posterior and inferior to the cavernous sinuses; pass through jugular foramen and end separately in the bulb of the internal jug vein
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basilar sinus
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plexus like collection of venous channels bet layers of dura on the clivus
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what sinus serves to connect the two inferior petrosal sinuses?
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basilar sinus!
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occipital sinus
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located in the fixed border of the falx cerebelli; drains into confluens of sinuses or the left transverse sinus
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confluens of sinuses
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dilatation at one side of internal occiptal protuberance; represents the jcn of the SSS, straight, occipital sinuses with the transverse sinuses of each side.
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clinical note on sinuses:
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profuse bleeding often occurs with skull fractures due to the fact that there is no smooth muscle in the walls of the dural venous sinuses to constrict the walls.; also because of the comm of veins outside the skull (i.e. scalp veins) with the venous sinuses via emissary veins, infections produced outside the skull can produce inflammation in the walls of the emissary veins resulting in thrombophlebitis of the sinuses.
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bones of anterior cranial fossa
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FRONTAL BONE: inner surface adn crest, orbital plates
ETHMOID BONE: cribiform plate and crista galli SPHENOID BONE: lesser wing and ant clinoid processes; jugum of sphenoid |
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parts of brain assoc with ant cranial fossa
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median part: olfactory bulbs, tracts, and stria; gyrus rectus
lateral part: orbital gyri of frontal lobe |
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foramina in ant cranial fossa
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foramina in cribiform plate in ethmoid bone: olfactory nerves from the nasal septum to the olfactory bulb
foramen cecum in base of frontal crest: emissary vein from nose to SSS ant and post ethmoidal foramina at jcn of ethmoid and orbital plate: ant and post ethmoidal vessels and nerves |
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structures of ACF
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frontal crest: attachment of f. cerebri
crista galli: attachment of falx cerebri ant clinoid process: attachment of free border of tent cbl |
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bones of middle cranial fossa
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SPHENOID BONE: body (tuberculum sellae, hypophoseal fossa, dorsum sellae with post clin processes) and greater wings
TEMPORAL BONE: squamous portion and superior portion of the petrous temporal bone |
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sphenoid body is also called
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sella turcica: tuberculum sellae, hyp fossa, and dorsum sellae
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parts of brain assoc with middle cranial fossa
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medial portion: diencephalic structures at base of brain
lat portion: temporal lobes |
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foramina of MCF
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OPTIC CANALS: CNII and ophthalmic artery
SUP ORBITAL FISSURE: CNIII, IV, VI, V1 FORAMEN ROTUNDUM: greater wing of sphenoid, CNV2 FORAMEN OVALE: greater wing: CNV3 FORAMEN SPINOSUM: greater wing: MMA FORAMEN LACERUM, apex of petrous temp, filled with cartilage, ICA crosses it going to cavernous sinus |
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Structures of MCF
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GROOVE FOR G. PETROSAL N.: petrous temporal: greater pet n.
GROOVE FOR L. PET. N: GROOVE FOR MMA TRIGEMINAL IMPRESSION: behind apex of petrous temp; semilunar ganglion ARCUATE EMINANCE: pet. temp, anterior semicircular canal HYPOPHYSEAL FOSSA: body of sphenoid, houses pit gland POST CLINOID PROCESSES: attachment of fixed border of t. cbl CAROTID CANAL: ICA, sympathetic plexus |
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bones of post cranial fossa
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OCCIPITAL: 3 portions: basilar, lateral, squamus
TEMPORAL: petrous temporal, mastoid portion of temp bone SPHENOID: post surface o fdorsum sellae of sphenoid |
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parts of brain assoc with PCF
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median: brain stem (midbrain, pons, medulla)
lateral: cerebellar hemispheres, above tentorium are occipital lobes |
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foramina of PCF
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FORAMEN MAGNUM: medulla SC jcn, spinal accessory nerve, vertebral a.
HYPOGLOSSEAL CANAL: CNXII JUGULAR FORAMEN: hiatus between occipital-petrous temp: ant part: Inf pet sinus; inf part: CNIX, X, XI; post part: Int Jug vein INTERNAL ACCOUSTIC MEATUS: pet temp; CRVII and VIII MASTOID FORAMEN: mastoid of temp: emissary vein |
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structures of PCF
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int occipital crest: attachment of falx cerebelli
int occip protub: attachment of t. cbl; confluens of sinuses |
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Telencephalon: CN, foramen, CF
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CNI; cribiform llplate, ACF
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Diencephalon: CN, foramen, CF
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II, optic canal MCF
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mesencephalon: CN, foramen, CF
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CNIII, IV, VI, V1
SOF, MCF |
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Metencephalon: CN, foramen, CF
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CNVI, V1, V2, V3, VII, VIII
VI and V1: SOF V2: foramen rotundum V3: foramen ovale VIII and VII: internal accoustic meatus; all MCF except IAM which is in PCF |
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mylencephalon: CN, foramen, CF
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IX, X, CRXI: jugular foramen
XII: hypoglossal canal all in PCF |
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telencephalon
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telencephalon: forebrain: cerebral hemispheres, certain subcortical fiber bundles, basal ganglia
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diencephalon
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between brain: thalamus, hypothalamus, subthalamus
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mesencephalon:
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midbrain
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metencephalon
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pons and cbl
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myelcephelon
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medulla
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orientation of cerebral hemispheres and diencephalon
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anterior = rostral
posterior = caudal superior = dorsal inferior = ventral |
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orientation of brain stem and spinal cord:
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anterior = ventral
posterior = dorsal superior = rostral inferior = caudal |
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what gyrus is the primary motor cortex:
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precentral gyrus
contralateral lateral: Face, hand, upper ext, trunk medial: lower ext and genetalia |
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broca's area:
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pars triangularis of IFG, and pars opercularis of IFG: speech formation in dominant hemisphere
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primary somatosensory ctx:
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postcentral gyrus: lateral: F, H, Upper ext, trunk
medial: lower ext and genetalia |
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functions of IPL
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lesion of dominant IPL (usually left): verbally mediated spatial functions, can't put words into proper relationships
lesion of non-dominant IPL disturbances of perception of spatial function other than language related, neglect of contralateral side of body |
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primary auditory ctx
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transverse gyrus of heschl, mostly bilaterally
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function of insula
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integrate visual, auditory, and somatosensory fcns
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cingulate sulcus turns up dorsally and ends as the
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marginal sulcus
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fcn of paracentral lobule
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motor and sensory functions of the lower ext and external genetalia
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organization of the brain stem: roof, central zone, basilar zone
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MIDBRAIN: roof: tectum (sup and inf coll)
central zone: tegmentum basilar: crus cerebri PONS: roof: cerebellum central zone: tegmentum basilar zone: basilar pons MEDULLA: roof: cerebellum central zone: reticular formation (aka tegmentum) basilar zone: pyramids |
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ventricular cavities lined by
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ependyma
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ventricular cavities of brain subdivisions: cavities of cerebral hemispheres:
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paired lat ventriclels I and II
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ventricular cavities of brain subdivisions: cavity of diencephalon
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unpaired third ventricle
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ventricular cavities of brain subdivisions: cavity of mesencephalon
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cerebral aqueduct
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ventricular cavities of brain subdivisions: cavity of pons and upper medulla (metencephalon)
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IV ventricle
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ventricular cavities of brain subdivisions: cavity of lower medulla and spinal cord (myelencphalon)
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central canal
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communicating foramina of the ventricular system
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INTERVENTRICULAR FORAMEN(foramen of munro)
FORAMINA of LUSCHKA (lateral) FORAMINA of MAGENDIE (medial) |
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choroid plexus is located in the:
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body, trigone and inferior horn of LV;
IVF; roof of III ventricle; caudal part of IV ventricle; foramina of Luschka |
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regions where SAS is expanded forms:
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cisterns, eventually become continuous with SAS surrounding cerebral hemispheres
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putamen + globus pallidus make up:
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lentiform nucleus
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strial terminalis
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communicates amygdala to septal region (happy place) but not other way around
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SAS expanded to form cisterns:
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cerebulomedullary cistern: (cisterna magna), between inf surface of cbl and medulla
Superior cistern: (cisterna ambiens) lies dorsal to the midbrain pontine, interpeduncular, and chiasmatic cisterns: lie ventral to base of pons, the interpeduncular fossa and the optic chiasm |
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one way direction of CSF circ: lateral ventricles:
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lat ventricules through formaina of munro into III ventricle, through cerebral aqueduct to IV ventrical. CSF exits the IV through paired foramina of luschka and unparied foramen of magendie
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one way direction of CSF circ: from foramen of magendie:
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From foramen of magendie, CSF enters the cerebellomedullary cistern, flows backward in SAS over post cbl, the superior cistern, the cerebral hemispheres, and drains chiefly into the SSS from arach granulations
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one way direction of CSF circ: from foramina of luschka:
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from f of luschka: CSF enters SAS of the pontine cistern and flows forward to the interpeduncular and chiasmatic cisterns, the SAS over the lat hemispheres and drains chiefly into the SSS from arach gran
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where is CSF formed chiefly?
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by choroid epithelia loc in portions of the lat ventricles, roofs of 3rd and 4th vent, and the formamina of luschka
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CSF is replaced how many times a day
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3-4 times
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chief functions of CSF
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maintenance of constant ext environment for n. and glia
removal of harmful brain metabolites through 1 way flow of CSF from vent syst around SC into SAS and into Vsinuses protection of CNS from trauma by the buoyancy effect reducing momentum of brain to trauma |
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protein concentration of CSF vs plasma
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dramatically reduced in CSF
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what concentrations are sl lower in CSF than plasma
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glucose, Ca, K
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pH of CSF in rel to art blood
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sl less in CSF
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CSF contains how many cells
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less than 4 cells: monocytes and lymphocytes
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CSF pressure is measured by what
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lumbar puncture bet 4th and 5th lumbar vertebrae
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clinical sig of CSF: color
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grossly bloody or yellow color indicates hemmorhage
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clinical sig of CSF: protein content
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protein over 150 indicates that biliruben bound to albumin has been brought from plasma to CSF; over 500 block in Spinal SAS by tumor, meningeal cancer or other compressing lesion
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clinical sig of CSF: WBC
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greater than 4/ml pathological: fungal inf: lymphocytes; bacterial meningitis: mostly neutrophils
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clinical sig of CSF: tumor cells
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exfoliate tumor cells may be in CSF in primary or metastatic brain cancer patients
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clinical sig of CSF: glucose
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conc of glucose is decreased in acute bacterial infection but rarely in viral infection
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clinical sig of CSF: MS
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in MS and other inflammatory diseases, the gamma-globulin content is increased in CSF whereas blood level of gamma globulin is normal
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hydrocephalus:
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"water brain": expansion of ventricles caused by increase of intracranial pressure caused by:
oversecretion of CSF impaired absorbtion of CSF obstruction of CSF circulation |
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communicating hydrocephalus
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oversecretion or impaired reabsorption of CSF
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noncommunicating hydrocephalus
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obstruction of CSF by blockage at cerebral aqueduct or foramina of IV ventricle
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hydrocephalus ex vacuo
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in aged indiv: no increase in intracranial pressure, due to thinning of cortical tissue; cerebral atrophy is primary pathology, not imbalance bet CSF formation and absorption
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types of brain edema
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vasogenic and cytotoxic
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vasogenic brain edema: cause, mechanism, manifestation/structures
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vasogenic brain edema: caused by ischemia, head trauma, meningitis
mechanism: inc perm of BBB, proteins and ions leak across capillary walls manifestations: inc in brain interstitial fluid, esp around white matter bordering ischemic zones inc. ICP decrease in size of ventricles |
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brain edema indicates:
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inc water content
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cytotoxic brain edema: cause, mech, manifest, structures
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cause: drug poisoning, hyponatremia (hypoxia)
mech: net shift of water from brain extracellular compartment to interior of cells manifest: dec in brain ISF, intracelular swelling of neurons, glia, and endothelia increased ICP dec in size of ventricles |
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3 fluid compartments of nervous system
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vascular
CSF extracellular |
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three specific barriers:
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BBB
Blood-CSF barrier CSF-brain barrier |
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BBB
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consists of endothelial cells with tight junctions
continuous basement membrane of the endothelial cells; transports substances that the brain consumes rapidly (glucose, aa, lactate, ribonucleosides) |
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blood-CSF barrier
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located at tight junctions which interconnect apical regions of cuboidal, choroid epithelium; transfer of nutrients that are needed in small amounts over extended pd: vit c, vit 6, folates
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CSF-brain barrier
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no tight jcns, therefore molecules move bidirectionally bet CSF and intercellular space of CNS
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transport mech across BBB
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diffusion
passive and active carrier type transporters ion channels and exchangers |
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nonselective luminal ion channel
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inhib by amiloride and atrial natriuetic peptide in capillary endothelial cells
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K+ channels
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expressed in astrocytes, play role in removal of extracellular K+ during intense neuronal activity
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Na+/H+ and Cl-/HCO-3 exchangers
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suggested to be expressed in luminal membrane
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