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12 Cards in this Set
- Front
- Back
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Which are the cell wall synthesis inhibitors? (2)
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- beta lactams
- glycopeptides |
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Which are the protein synthesis inhibitors? (4)
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- macrolids
- lincosamides - aminoglycosides - tetracyclines |
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Which are the nucleic acid synthesis inhibitors? (3)
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- sulfonamides
- quinolones - metronidazole |
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Macrolid prototypes?
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-MYCIN
Erythromycin Clarithromycin Azithromycin |
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Macrolid MOA?
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- Protein synthesis inhibitor
- Bacteriostatic - Bactericidal at high [] |
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Macrolid spectrum?
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Broadly covers GRAM +VE COCCI
- S aureus - S pneumonia Atypical organisms - Mycoplasma (no cell wall) - Chlamydia pneumonia (obligate intracellular) - Legionella pneumophillia (facultative intracellular) Gram +ve - H influenza - B. Pertussis - M. catarrhalis |
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Common use for Macrolids?
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Community aquired resp. tract infections
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Lincosamides: Prototype
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Clindamycin
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Lincosamides: MOA
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Protein synthesis inhibitor
- bacteriostatic - good tissue penetration - good oral absorption (and IV) |
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Lincosamides: specturm
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Gram +ve Cocci
- Staph spp - Strep spp - MRSA (some) - Enterococci Anaerobes - bacteroides fragilis - oral anaerobes Toxin Reduction - TSS (Group A strep or Staph Aureus) NB: most gram -ves are resisitant |
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Aminoglycosides: Prototypes (4)
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-YCIN
- Streptomycin - Gentamycin - Tobramycin - Amikacin |
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Aminoglycosides: MOA
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Protein synthesis inhibitor
- bacteriocidal at certain doses ( [] dependant killing) - pass across outer membrane of gram -ve bacteria by disrupting bridges bw lipopolysaccaride molecules - synergistic effect with |
