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25 Cards in this Set

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6 major groups of antidepressants:
1) cyclic antidepressants (TCA)
2) Selective Serotonin Reuptake Inhibitors (SSRI)
3) Serotonin & Norepinephrine Reuptake Inhibitors (SNRI)
4) Norepinephrine inhibitors (NRI)
5) monoamine oxidase inhibitors (MAOI)
6) atypicals
True or False: Tricyclics are considered "dirty drugs" because they react with a number of receptors besides the one responsible for the therapeutic effect.
True
True or False: Tricyclics are quite toxic and even a small overdose can be lethal.
True
SSRI's drugs:
Prozac, Zoloft, Paxil, Lexapro
SNRI's drugs:
Cymbalta, Effexor, Remeron
NRI drug:
Strattera
Atypical drugs:
Wellbutrin, BuSpar
MAOI (monoamine oxidase) drugs:
nardil, parnate
Stimulant drugs:
dexedrine, ritalin
True or False: It is important to treat remission, not improvement
True
True or False: With the possible exception of severe and melancholic depression, all antidepressants have similar efficacy.
True
Activation
the acute onset of side effect seen within the first few hours after starting an antidepressant or when doses are increased. typically lasts only a week or two
Switching
occurs when a person being treated with an antidepressant is provoked into a manic state. switching does not occur until after several weeks of treatment
Treatment resistant depression
refers to a depression that has failed to respond to adequate trials of two or more antidepressants. As many as 10-20% of people with depression fall into this category.
3 over the counter products shown to have efficacy in the treatment of depression:
1) St Johns Wart (do not take with another antidepressant, 1 week washout)
2) SAM-e (s-adenosyl-methionine)
3) Omega-3 fatty acids (unipolar & bipolar depression)
True or False: For treating bipolar disorder, pharmacotherapy is unquestionably the mainstay of treatment.
True
First-line agents for the treatment of bipolar disorder:
Lithium & divalproex (Depakote)
Therapeutic Window
the therapeutic dose is very close to the toxic dose. (lithium has a very narrow therapeutic window)
Lithium has an effect on what two neurotransmitters:
dopamine & norepinephrine
3 Anticonvulsants:
1) carbamazepine
2) divalproex
3) lamotrigine
atypical antipsychotic:
Olanzapine
True or False: Patients with bipolar disorder frequently require multiple medications or changes in therapy
True
True or False: antidepressants are a good choice of treatment for bipolar disorder.
False: they can actually induce rapid cycling
Patients with bipolar typically face __________ treatment.
lifelong (long-term)
Some patients may actually become ______ responsive to mood-stabilizing treatment with repeated with episodes of mania.
less