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15 Cards in this Set
- Front
- Back
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What is phantastica?
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-Drug capable of altering perceptions
-Aware of fantasy and reality simultaneously -Little physiological toxicity, mostly psychological |
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What are some hallucinogen types and examples of them?
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indole - LSD
catechol - mescaline amphetamine derivatives - MDA deliriants - PCP |
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What are examples of indole backbone substances?
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-Serotonin
-LSD -psylocibin (mushrooms) -lycergic acid amide (Morning Glory) -Bufotenin (Toads) |
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What are examples of catachol backbone substances?
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-dopmine and noradrenaline
-mescaline (cactus) -MDA MDMA (ecstasy) |
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What is ergot?
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-Fungus that infects rye
-hallucination, convulsions |
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What are some psychological effects of LSD?
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-Psychotic reactions, unpredictable and frightening flashbacks, link to schizo these all led to its decline
-Hallucination -Synethesia -Intense emotion -time distortion -mystical experience |
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is LSD reinforcing?
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LSD and other hallucinogens are not reinforcing with the exception of deleriants
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How is LSD administered?
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-Mostly orally
-10-300ug -blotting paper, microdots on pills/candies -gel tabs, LSD in gelatin |
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Is LSD habit forming?
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No, mostly used recreationally. Set and setting are very important in determining trip.
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What is metabolism and excretion of LSD?
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-Effects begin 30-90 minutes after ingestion
-1% enters brain -Metabolized by liver -1/2 life of 110 minutes |
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What are some physiological effects of LSD?
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-inceased BP
-vasoconstriction -sweating -dialated pupils -increased salivation |
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What is the mechanism of LSD?
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-agonist at 5HT2A/B/C receptors (serotonin)
-A/B in NA and Prefrontal cortex -activation changes gene expression -Increases glutamate release from cortex - biggest contributor to hallucination -Prefrontal cortex controls how you understand and decode information -LSD enhances LC, ordinary seems extraordinary -Stimulates (over) D2 receptors for dopamine |
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what is the harm caused by LSD?
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no reported deaths from overdose. Physiologically safe. Flashbacks due to release from bodyfat?
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How is LSD tolerated?
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-develops quickly
-5HT2 receptors rapidly disappear -resensitive in a week -Cross tolerant to mescaline and mushrooms |
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What are LSD withdrawal symptoms?
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No withdrawal, no addiction, not continuously used
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