Haematology Pharma

Front 1

This agent is a cofactor for activation of antithrombin.

Back 1

Heparin

Front 2

Clinical use of heparin?

Back 2

Used for PE, ACS, MI, DVT, can be used during pregnancy

Front 3

Used for PE, ACS, MI, DVT, can be used during pregnancy.

Back 3

Heparin

Front 4

Argatrobam, bivalirudin clinical use?

Back 4

Inhibits thrombin, used for heparin-induced thrombocytopenia

Front 5

Inhibits thrombin, used for heparin-induced thrombocytopenia

Back 5

Argatrobam, bivalirudin

Front 6

Warfarin (coumadin) clinical use?

Back 6

Chronic anticoag.; STEMI, venous thromboembolism prophylaxis

Front 7

Warfarin (coumadin) side effects?

Back 7

Bleeding, teratogenic, skin/tissue necrosis, drug-drug interactions

Front 8

Name direct factor Xa inhibitors.

Back 8

Apixaban, rivaroxaban

Front 9

Apixaban, rivaroxaban are what type of agents?

Back 9

Direct factor Xa inhibitors.

Front 10

Apixaban clinical use?

Back 10

Rx/prophylaxis of PE and DVT.

Front 11

Rx/prophylaxis of PE and DVT.

Back 11

Apixaban, rivaroxaban

Front 12

Examples of thrombolytics?

Back 12

Alteplase (tPA), tenecteplase (TNK-tPA)

Front 13

Alteplase (tPA), tenecteplase (TNK-tPA), are examples of what type of agents?

Back 13

Thrombolytics

Front 14

Alteplase clinical use?

Back 14

Early MI, early ischemic stroke, severe PE

Front 15

Reteplase clinical use?

Back 15

Early MI, early ischemic stroke, severe PE

Front 16

Examples of ADP receptor inhibitors?

Back 16

Clopidogrel, ticlopidine, prasugrel

Front 17

Clopidogrel, ticlopidine, prasugrel are examples of what type of agents?

Back 17

ADP receptor inhibitors

Front 18

ADP receptor inhibitors clinical usage?

Back 18

ACS; coronary stenting-decrease thrombotic stroke occurrences

Front 19

Cilostazol, dipyridamole function?

Back 19

Inhibit phosphodiesterase III causing increase cAMP in platelets>inhibits platelet aggregation

Front 20

Cilostazol, dipyridamole clinical use?

Back 20

Intermittent claudication, coronary vasodialtion, prevent stroke/TIAs, angina prophylaxis

Front 21

Examples of GPIIb/IIIa inhibitors?

Back 21

Abciximab, eptifibatide, tirofiban

Front 22

Clinical use of abciximab? S/E?

Back 22

Unstable angina. Bleeding, thrombocytopenia

Front 23

Dactinomycin is used for?

Back 23

Wilms tumour, Ewing sarcoma, rhabdomyosarcoma, childhood tumours

Front 24

Used forWilms tumour, Ewing sarcoma, rhabdomyosarcoma, childhood tumours.

Back 24

Dactinomycin

Front 25

Doxorubicin clinical use?

Back 25

Solid tumours, leukaemias, lymphomas

Front 26

Used forsolid tumours, leukaemias, lymphomas

Back 26

Doxorubicin

Front 27

Bleomycin clinical use?

Back 27

Testicular cancer, Hodgkin lymphoma

Front 28

Used fortesticular cancer, Hodgkin lymphoma

Back 28

Bleomycin

Front 29

Clinical use of cyclophosphamide?

Back 29

Solid tumours, leukemia, lymphomas

Front 30

Clinical use of nitrosureas?

Back 30

Brain tumours

Front 31

Clinical use of Busulfan?

Back 31

CML, bone marrow ablation before transplant

Front 32

Vincristine mechanism?

Back 32

Bind beta-tubulin; inhibits polymerization into microtubules causing M-phase arrest

Front 33

Vincristine clinical use?

Back 33

Solid tumours, leukemias, lymphomas

Front 34

Paclitaxel clinical use? S/Es?

Back 34

Ovarian and breast carcinomas. Myelosuppression, alopecia, HS

Front 35

Cisplatin/carboplatin mechanism? Clinical use?

Back 35

Cross-link DNA. Testicular, bladder, ovary, and lung carcinomas

Front 36

Etoposide mechanism and clinical use?

Back 36

Inhibits topoisomerase II>inc. DNA degradation. Solid tumours, leukemias, lymphomas

Front 37

Irinotecon clinical use? S/Es?

Back 37

Colon cancer. Severe myelosuppression, diarrhea

Front 38

Hyrdoxyurea clinical use?

Back 38

Melanoma, CML, sickle cell disease

Front 39

Prednisone clinical use in oncology?

Back 39

CLL, non-hodgkins

Front 40

What is tamoxifen?

Back 40

Selective estrogen receptor modulator; antagonist in breast and agonist in bone

Front 41

What is rituximab?

Back 41

Monoclonal Ab against CD20

Front 42

Clinical use of vemurafenib?

Back 42

Metastatic melanoma

Front 43

What is bevacizumab?

Back 43

Monoclonal antibody against VEGF; inhibits angiogenesis

Front 44

Clinical use of bevacizumab?

Back 44

Solid tumours, ex. colorectal cancer, renal cell carcinoma