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13 Cards in this Set

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Abacavir Sulfate
Ziagen
NRTI

Oral Solution: 20 MG/ML
Oral Tablet: 300 MG
Adults:300mg PO BID / 600mg qd
3mo-16yrs:8 mg/kg PO BID
Renal:N/A Hepatic:CI-mod-sev

B-BOX:multiorgan clin syndm, & LA and severe hepatomegaly

Preg Cat: B

AE=GI:D/N/V Neruo:HA,Fatigue
Serious=LA,H-megaly,Immune RxN

ADME
PO F=83% Effect of food: none
PB:50% Metabolism
CYP450 independent, alcohol dehydrogenase, glucuronyl transferase (1 act metab)
Excretion uc=F-16% R-1.2%
Dialyzable: unknown
t1/2=1.5h +/- 0.63 h
Didanosine
Videx
NRTI

Generic
PO DR:200MG,250MG,400MG
Videx EC
PO DR:125MG,200MG,250MG,400MG
Videx Pediatric
Oral Powder for Suspension: 10 MG/ML
Adults:125-400mg PO Q-BID
HIV infection: 2 weeks to 8 months of age, 100 mg/m(2) ORALLY twice daily
8mo=120 mg/m(2)PO BID
Renal:YES Hepatic:n/a

B-BOX:Pancratitis, & LA and severe hepatomegaly

Caution: allopurinol, hydroxyurea, powder has Na
Preg Cat: B

AE=rash/fev/D/N/V, lipoD,shiver Neruo:HA,asthenia
Serious=LA,H-megaly,Panctitis,P-neuropthy, optic neur. retinal d/o

ADME
PO F=37 adults F=2-89% kids
Active metabolite
Excretion R-50%
t1/2=0.8-1.5h
Tenofovir
Viread
NRTI
Adults:300mg PO BID / 600mg qd
3mo-16yrs:8 mg/kg PO BID
Renal:N/A Hepatic:CI-mod-sev

B-BOX:multiorgan clin syndm, & LA and severe hepatomegaly

Preg Cat: B

AE=GI:D/N/V Neruo:HA,Fatigue
Serious=LA,H-megaly,Immune RxN

ADME
PO F=83% Effect of food: none
PB:50% Metabolism
CYP450 independent, alcohol dehydrogenase, glucuronyl transferase (1 act metab)
Excretion uc=F-16% R-1.2%
Dialyzable: unknown
t1/2=1.5h +/- 0.63 h
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Tenofovir Disoproxil Fumartate
Viread
NRTI

300mg tablets
Adults: 300mg PO qd
Peds: n/a
Renal: YES Hep: NO

B-BOX: LA, hepatomeg, exacerbts Hep B

Preg Cat: B

AE: LipoD, D/Gas/N/V, Osteropenia, asthenia
Serious:LA, h-megly, Relaps Hep-B, Acute RF, Fanconi synd

ADME
F=25% increase w food
E=R:70-80% uc
Zidovudine
Retrovir
NRTI

Generic
Oral Capsule: 100 MG
Oral Syrup: 50 MG/5 ML
Oral Tablet: 300 MG
Retrovir
Intravenous Solution: 10 MG/ML
Oral Capsule: 100 MG
Oral Syrup: 50 MG/5 ML
Oral Tablet: 300 MG
Adults: 200mg TID / 300mg BID
IV: 1mg/kg/dose 5-6 daily
Do NOT give IM
Peds & perinatal transmission
Renal: when<15ml/min Hep:YES
Anemia: (Hgb<7.5 or -25%) d/c
Neutropenia:(grnul<750/-50%)

Prolong use causes myopathy

Preg Cat: C

AE: Consp/N/V, los of ap asthenia,HA,insomnia, malaise
Serious:LA, h-megly, Anemia, neutropenia, DI myopathy

ADME
F=65%(A) 89%(N) 65%(Peds)
PB=<38%
Met:Hepatic,major metabolite
E=R:18%(A) 30%(Peds)
t1/2=1hr(A) 1.8hr (Peds)
Efavirenz
Sustiva
NNRTI

Capsule: 50MG, 100MG, 200MG
Tablet: 600MG
Adults: 600mg PO qd
Peds: wt based dosing
Renal:No Hep:Caution/n/a

Pychiatric SE
take on empty stomach & HS

Preg Cat: D

AE: rash,lipoD,Dz,insomnia,depression, dreams, hallucinations
Serious:Sz, aggressive, manic persecution,suicidal thoughts

ADME
A:>with high fat meal
Met:3A4 and 2B6
E=R:14-34% uc F:16-61%
t1/2=40-55hr
Delavirdine Mesylate
Rescriptor
NNTRI

tablets: 100mg, 200mg

may disperse in water
Adult: 400mg PO TID
≥16 yr: 400mg PO TID
Renal:N/A Hep:N/A

Preg Cat: C

AE: rash,lipoD,N/V, myalgia, HA,fatigue
Serious:Stev-John, erthema multiforme

ADME
F=85%
Met:3A4 and 2D6
E=R:51% uc F:44%
t1/2=5.8hr
Nevirapine
Viramune
NNRTI

Suspension: 50MG/5ML
Tablet: 200MG
Adult: 200mg qd then bid.
Do not start is CD4>250F/400M
Peds:mg/m2 dosing
Perinatal transmission
Renal:N/A >20 good Hep:not rec in severe
B-Box:fatal hepatotox in 1st 18 wks (>Women,>CD4), Stev-John, toic epidermal necrolysis

Preg Cat: B

AE: rash,lipoD,N,HA,fatigue
Serious:Stev-John, Anemia, Neutropen, granulocytopenia, liver failure

ADME
F=90% PB=60%
Met:3A4 and 2B6
E=R:81% F:10% dialyz 50% remov
t1/2=25-30hr
Ritonavir
Norvir
PI

100mg liquid filled caps
80mg/ml PO solution
Adult:600 mg PO BID
Peds: Initial 300mg BID, increase over 5d to 600mg BID
Renal: No Hep:No in mild-mod, monitor in severe

B-Box: CI nonsed antihistamines, sed hypnot, AA, ergots

CI: narrow TR Rxs, caution P450 3A or 2D6

Preg Cat: B

AE: Paresthesia, circumoral, DM, lipoD, D/LOS/N/V/Panctit/Taste alt,LFTs,Asthenia(most comon)
Serious:DM(new/exacerbat)lipids,panctits, hepatitis

ADME
Food increase Abspt PB=99%
Met:3A (major)and 2D6
active metab
E=R:11.3% F:86.4%-(33.8& uc) remov
t1/2=3-5hr
Indinavir Sulfate
Crixivan
PI

Caps: 100mg, 333mg, 400mg
Adult: 800mg Q8h
Peds:800mg Q8h
4-15 yrs:500 mg/m2 Q8h
Ren=N/a Hep=600mg q8h mild-mod

Statins increase myop/rhabdo. 3A4 DI, PDE5

Preg Cat: C

AE: LipoD, N/V,hyperbili, backache
Serious:DM,hem anemia, hepatitis, nephrolithiasis

ADME
Food dec AUC 77% PB=60%
Met:3A4 (major)
glucuronide and oxidative meta
E=R:19%(<20% uc) F:83%
t1/2=1.8hr
Emtricitabine
Emtriva
NRTI

Caps: 200 mg
PO Solution: 10mg/ml
Adult:200mg QD
Peds: wt based
Renal:YES Hep:N/A Hemo: 200mg q96h

B-Box:LA,Hepmag, HBV exacb

Preg Cat: B

AE:hyperpigmentation of skin, rash, d/n/v,HA
Serious:LA, hepatomg,steatosis

ADME
F=93%
Met: systemic
E=R:86% F:14%
t1/2=10hr
Lamivudine
Epivir
NRTI

Epivir HBV
PO Solution 5mg/ml
tablet:100mg

Epivir
PO solution: 10mg/ml
tablets:150mg, 300mg
Adult:150mg BID OR 300mg QD
Peds: wt based

B-Box:

Preg Cat: B

AE:
Serious:

ADME
Food increase Abspt PB=99%
Met:3A (major)and 2D6
E=R:11.3% F:86.4%-(33.8& uc) remov
t1/2=3-5hr