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13 Cards in this Set
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Abacavir Sulfate
Ziagen NRTI Oral Solution: 20 MG/ML Oral Tablet: 300 MG |
Adults:300mg PO BID / 600mg qd
3mo-16yrs:8 mg/kg PO BID Renal:N/A Hepatic:CI-mod-sev B-BOX:multiorgan clin syndm, & LA and severe hepatomegaly Preg Cat: B AE=GI:D/N/V Neruo:HA,Fatigue Serious=LA,H-megaly,Immune RxN ADME PO F=83% Effect of food: none PB:50% Metabolism CYP450 independent, alcohol dehydrogenase, glucuronyl transferase (1 act metab) Excretion uc=F-16% R-1.2% Dialyzable: unknown t1/2=1.5h +/- 0.63 h |
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Didanosine
Videx NRTI Generic PO DR:200MG,250MG,400MG Videx EC PO DR:125MG,200MG,250MG,400MG Videx Pediatric Oral Powder for Suspension: 10 MG/ML |
Adults:125-400mg PO Q-BID
HIV infection: 2 weeks to 8 months of age, 100 mg/m(2) ORALLY twice daily 8mo=120 mg/m(2)PO BID Renal:YES Hepatic:n/a B-BOX:Pancratitis, & LA and severe hepatomegaly Caution: allopurinol, hydroxyurea, powder has Na Preg Cat: B AE=rash/fev/D/N/V, lipoD,shiver Neruo:HA,asthenia Serious=LA,H-megaly,Panctitis,P-neuropthy, optic neur. retinal d/o ADME PO F=37 adults F=2-89% kids Active metabolite Excretion R-50% t1/2=0.8-1.5h |
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Tenofovir
Viread NRTI |
Adults:300mg PO BID / 600mg qd
3mo-16yrs:8 mg/kg PO BID Renal:N/A Hepatic:CI-mod-sev B-BOX:multiorgan clin syndm, & LA and severe hepatomegaly Preg Cat: B AE=GI:D/N/V Neruo:HA,Fatigue Serious=LA,H-megaly,Immune RxN ADME PO F=83% Effect of food: none PB:50% Metabolism CYP450 independent, alcohol dehydrogenase, glucuronyl transferase (1 act metab) Excretion uc=F-16% R-1.2% Dialyzable: unknown t1/2=1.5h +/- 0.63 h |
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Tenofovir Disoproxil Fumartate
Viread NRTI 300mg tablets |
Adults: 300mg PO qd
Peds: n/a Renal: YES Hep: NO B-BOX: LA, hepatomeg, exacerbts Hep B Preg Cat: B AE: LipoD, D/Gas/N/V, Osteropenia, asthenia Serious:LA, h-megly, Relaps Hep-B, Acute RF, Fanconi synd ADME F=25% increase w food E=R:70-80% uc |
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Zidovudine
Retrovir NRTI Generic Oral Capsule: 100 MG Oral Syrup: 50 MG/5 ML Oral Tablet: 300 MG Retrovir Intravenous Solution: 10 MG/ML Oral Capsule: 100 MG Oral Syrup: 50 MG/5 ML Oral Tablet: 300 MG |
Adults: 200mg TID / 300mg BID
IV: 1mg/kg/dose 5-6 daily Do NOT give IM Peds & perinatal transmission Renal: when<15ml/min Hep:YES Anemia: (Hgb<7.5 or -25%) d/c Neutropenia:(grnul<750/-50%) Prolong use causes myopathy Preg Cat: C AE: Consp/N/V, los of ap asthenia,HA,insomnia, malaise Serious:LA, h-megly, Anemia, neutropenia, DI myopathy ADME F=65%(A) 89%(N) 65%(Peds) PB=<38% Met:Hepatic,major metabolite E=R:18%(A) 30%(Peds) t1/2=1hr(A) 1.8hr (Peds) |
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Efavirenz
Sustiva NNRTI Capsule: 50MG, 100MG, 200MG Tablet: 600MG |
Adults: 600mg PO qd
Peds: wt based dosing Renal:No Hep:Caution/n/a Pychiatric SE take on empty stomach & HS Preg Cat: D AE: rash,lipoD,Dz,insomnia,depression, dreams, hallucinations Serious:Sz, aggressive, manic persecution,suicidal thoughts ADME A:>with high fat meal Met:3A4 and 2B6 E=R:14-34% uc F:16-61% t1/2=40-55hr |
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Delavirdine Mesylate
Rescriptor NNTRI tablets: 100mg, 200mg may disperse in water |
Adult: 400mg PO TID
≥16 yr: 400mg PO TID Renal:N/A Hep:N/A Preg Cat: C AE: rash,lipoD,N/V, myalgia, HA,fatigue Serious:Stev-John, erthema multiforme ADME F=85% Met:3A4 and 2D6 E=R:51% uc F:44% t1/2=5.8hr |
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Nevirapine
Viramune NNRTI Suspension: 50MG/5ML Tablet: 200MG |
Adult: 200mg qd then bid.
Do not start is CD4>250F/400M Peds:mg/m2 dosing Perinatal transmission Renal:N/A >20 good Hep:not rec in severe B-Box:fatal hepatotox in 1st 18 wks (>Women,>CD4), Stev-John, toic epidermal necrolysis Preg Cat: B AE: rash,lipoD,N,HA,fatigue Serious:Stev-John, Anemia, Neutropen, granulocytopenia, liver failure ADME F=90% PB=60% Met:3A4 and 2B6 E=R:81% F:10% dialyz 50% remov t1/2=25-30hr |
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Ritonavir
Norvir PI 100mg liquid filled caps 80mg/ml PO solution |
Adult:600 mg PO BID
Peds: Initial 300mg BID, increase over 5d to 600mg BID Renal: No Hep:No in mild-mod, monitor in severe B-Box: CI nonsed antihistamines, sed hypnot, AA, ergots CI: narrow TR Rxs, caution P450 3A or 2D6 Preg Cat: B AE: Paresthesia, circumoral, DM, lipoD, D/LOS/N/V/Panctit/Taste alt,LFTs,Asthenia(most comon) Serious:DM(new/exacerbat)lipids,panctits, hepatitis ADME Food increase Abspt PB=99% Met:3A (major)and 2D6 active metab E=R:11.3% F:86.4%-(33.8& uc) remov t1/2=3-5hr |
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Indinavir Sulfate
Crixivan PI Caps: 100mg, 333mg, 400mg |
Adult: 800mg Q8h
Peds:800mg Q8h 4-15 yrs:500 mg/m2 Q8h Ren=N/a Hep=600mg q8h mild-mod Statins increase myop/rhabdo. 3A4 DI, PDE5 Preg Cat: C AE: LipoD, N/V,hyperbili, backache Serious:DM,hem anemia, hepatitis, nephrolithiasis ADME Food dec AUC 77% PB=60% Met:3A4 (major) glucuronide and oxidative meta E=R:19%(<20% uc) F:83% t1/2=1.8hr |
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Emtricitabine
Emtriva NRTI Caps: 200 mg PO Solution: 10mg/ml |
Adult:200mg QD
Peds: wt based Renal:YES Hep:N/A Hemo: 200mg q96h B-Box:LA,Hepmag, HBV exacb Preg Cat: B AE:hyperpigmentation of skin, rash, d/n/v,HA Serious:LA, hepatomg,steatosis ADME F=93% Met: systemic E=R:86% F:14% t1/2=10hr |
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Lamivudine
Epivir NRTI Epivir HBV PO Solution 5mg/ml tablet:100mg Epivir PO solution: 10mg/ml tablets:150mg, 300mg |
Adult:150mg BID OR 300mg QD
Peds: wt based B-Box: Preg Cat: B AE: Serious: ADME Food increase Abspt PB=99% Met:3A (major)and 2D6 E=R:11.3% F:86.4%-(33.8& uc) remov t1/2=3-5hr |
