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18 Cards in this Set
- Front
- Back
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Concerning development of granulocytes, how many stages?
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5 stages
myeloblas promyelocyte myelocyte metamyelocyte mature granulocyte my my my meat is mature |
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Waht is similar in 1st three parts of development of granulocytes? Different
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myeloblas
promyelocyte Both have open and prominent nuclei and basophilic cytoplasm myelocyte condensed nucleus myeloblast-baby blue (basophilic cytoplasm) without granules promyeloblast-basophilic cyt with azurophilic granules (reddish purple) myelocyte-specific granules increase |
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what is diff between metamyelocyte and myelocyte
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meta has indented nucleus
myelocyte is condensed and round meta has more dominant specific granules myelocyte has less metamyleocyte can include 3 subtypes and 3 post subtypes (band cell) of each n eo baso |
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What are six stages of RBC?
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bun (proerythroplast)
shoe (basil out of shoe) basophilic erythroblast) tree poly chromatophilic erythroplast (many grapes of diff colors) door orthochromatic erythroblast (normoblast) hive retuculocyte (culo) stix mature |
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What is char of basophilic erythroblast?
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cytoplasm basophilic, nucleus condensed and no nuclei (polyribosomes are reason for basophilia)
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Why is polychromatophilic erythroblasts as such?
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more Hgb
also nucleus is smaller |
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What distinct about orthochromatic erythroblast
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small, pyknotic nucleus, cytoplasm acidophilic (liker RBC)
nucleus extruded |
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What are in reticulocytes?
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small ribosomes (poly)
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What are 3 changes in granuloctyes that occur in their development?
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nucleus becomes lobated or indented
cell volume decreases cytoplasm becomes filled with granules specific to the cell type |
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What does Erythropoietin stim?
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EPO stims CFC-Erythroid to become Proerythroblast which later becomes erythrocyte
Cuff and Crease Erythroid to Pro EB to EC |
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What does Thrombo do?
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Thrombopoietin stim
CFC-Megakaryocytes to become Megakaryoblasts, which become megakaryocytes which become platelets Cuff and Crease Mega KC to Mega KB to Mega KC to platelets |
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What does IL-5 do?
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CFC Eosinophil to become Myeloblast which becomes Eosinophil.
Cuff and Crease E to My B to E |
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What are the 3 major steps of Hematoangoigenesis?
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1st) M T H: SC to BC
2nd) PPSC; 2 weeks BI; V, H and A 3rd) CFU and CFC, (involves CFU-GEMM, GM-CSF, EPO, Thrombo and IL-5 and IL-3) Monophyletic Theory of Hematopoiesis: blood cells from common stem cell Mono Throw Hemp; stem to common Pluripotential stem cells (PPSC) found in "blood island" of yolk sac at 2 weeks. Vasculogenic Hematopoietic; angoigenic Power Puff SC; val hermione and Angie PPSC to different Colony-Forming Cells or Units (college of FU or F your celf) involves the multipotential myeloid stem cell: Colony-Forming Unit Granulocytic Erythroid Megakaryocytic Monocytic (becomes one of those 4) Columbus Forwarded US GEMM Involves IL-3 and GM-SCF (interleukin 3 and Granulocyte-macrophage colony-stimulating factor) il 3 ships illegal and GM crashed Spanish Flotilla to stim CFU-GEMM to form Eerie Men Bo (erythrocytes megakaryocytes neutrophils, eosinophils or basophils) |
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What is the difference between self-renewal and differentiation?
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daughter cells are copies (self-renewal) while progenitors are more restricted (in terms of lineage)
Differentiation is acquisition of genotypic and phenotypic characteristics of mature tissue-forming specific cell types and depends on the microenvironment (type and concentration of growth factors as well as ECM interactions) |
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Red marrow structure? (3)
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1.) CT stroma (framework) of reticular cells and fibers
(rat-sickle in stomach has fiber) 2.) sinusoid capillaries (cap sinister) 3.) Chords of blood-forming cells (bloody chords) |
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Where is bone marrow foun
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Canada caves
long island metal caviies Cavities of cancellous bones Medullary cavity of long bones |
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What is term for formation of platelets
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megakaryocytopoiesis
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What are the 3 steps of forming a clot and repairing the vessel wall?
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1.) Primarily Agro: college butt play
2.)Police act a.) Alpha frat friggin mates b.) Deltas sorority release Sara who is good with vaginal contraction 3.) Cleanup and removal -planes generate cleanup -PDGF Police department golfs Primary aggregation: attach to interstitial collagen exposed after endothelial injury- platelet plug Platelet activation (secondary aggregation) alpha fibrinogen and fiber to make a mat for formed blood products and platelets delta-seratonin contract smooth vascular muscle Clot retraction and removal (plasminogen to plasmin) after PDGF stimulates BV regrowth |
