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10 Cards in this Set
- Front
- Back
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what are the forms of malignant gestation trophoblastic disease?
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choriocarcinoma
invasive mole = chorioadenoma destruens trophoblastic tumor, eg placental-site or even rarer epitheloid |
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what is the growth pattern in choriocarcinoma?
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highly aggressive carcinoma typically with early and extensive hematogenous carcinoma
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what is the pattern of metastasis in invasive mole?
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metastasis is rare
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what are feared complications of choriocarcinoma?
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intrabdominal and intracerebral bleeding from liver and brain metastases
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what is the growth pattern in invasive mole?
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local destructing growth into myometrium
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what are histological characteristics of invasive mole?
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proliferation of hydropic chorion villi invasive into myometrium
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what are histological characteristics of choriocarcinoma?
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abscence of chorion villi, in contrast to invasive mole
purely epithelial tumor of cyto- and syncytiotrophoblast |
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when do gestational trophoblastic neoplasia occur?
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after pregnancy
after hydatidiform moles after abortions, induced abortions and EUG |
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what are therapy principles for gestational trophoblastic neoplasia?
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single-agent chemotherapy for nonmetastatic or metastatic low-risk GTN, ie methotrexate or dactinomycin when liver function poor
single-agent chemotherapy for high-risk metastatic GTN with lower WHO scores etoposide, methotrexate and dactinomycin in first week then cyclophosphamide and vincristin in second week for WHO scores >= 7 |
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what are the most frequent sites of metastases for GTN?
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lungs, brain, liver, kidney, and gastrointestinal tract
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