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10 Cards in this Set

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what are the forms of malignant gestation trophoblastic disease?
choriocarcinoma

invasive mole = chorioadenoma destruens

trophoblastic tumor, eg placental-site or even rarer epitheloid
what is the growth pattern in choriocarcinoma?
highly aggressive carcinoma typically with early and extensive hematogenous carcinoma
what is the pattern of metastasis in invasive mole?
metastasis is rare
what are feared complications of choriocarcinoma?
intrabdominal and intracerebral bleeding from liver and brain metastases
what is the growth pattern in invasive mole?
local destructing growth into myometrium
what are histological characteristics of invasive mole?
proliferation of hydropic chorion villi invasive into myometrium
what are histological characteristics of choriocarcinoma?
abscence of chorion villi, in contrast to invasive mole

purely epithelial tumor of cyto- and syncytiotrophoblast
when do gestational trophoblastic neoplasia occur?
after pregnancy

after hydatidiform moles

after abortions, induced abortions and EUG
what are therapy principles for gestational trophoblastic neoplasia?
single-agent chemotherapy for nonmetastatic or metastatic low-risk GTN, ie methotrexate or dactinomycin when liver function poor

single-agent chemotherapy for high-risk metastatic GTN with lower WHO scores

etoposide, methotrexate and dactinomycin in first week then cyclophosphamide and vincristin in second week for WHO scores >= 7
what are the most frequent sites of metastases for GTN?
lungs, brain, liver, kidney, and gastrointestinal tract