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9 Cards in this Set
- Front
- Back
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GTN Presentation |
0.6mg tablets Transdermal GTN patch (50mg 0.4mg/hr release) |
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GTN Pharmacology |
Principally, a vascular smooth muscle relaxant Actions: - Venous dilatation promotes venous pulling and reduces venous return to the heart (reduces preload) - Arterial dilatation reduces systemic vascular resistance and arterial pressure (reduces afterload) |
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GTN Pharmacology |
The effects of the above are: - Reduced myocardial O2 demand - Reduced systemic, diastolic and mean arterial pressure, whilst usually maintaining coronary perfusion pressure - Mild collateral coronary arterial dilatation may improve blood supply to ischaemic areas of the myocardium - Mild tachycardia secondary to slight fall in BP - Preterm labour: Uterine quiescence in pregnancy |
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GTN Primary Emergency Indications |
Preterm labour (consult) Acute LVF Autonomic dysreflexia Chest pain with ACS Hypertension associated with ACS |
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GTN Contraindications |
1. Known hypersensitivity 2. Systolic BP <110mmHg tablet 3. Systolic BP <90mmHg patch 4. Viagra or Levitra administration in the previous 24hr or Cialis administration in the previous 4 days 5. HR >150bpm 6. Bradycardia HR <50bpm 7. VT 8. Inferior STEMI with systolic BP <160mmHg 9. Right ventricular infarct |
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GTN Precautions |
Concurrent use with other tocolytics Elderly patients Recent MI No previous administration |
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GTN Route of Administration |
SL Buccal Transdermal Infusion (interhospital transfer only) |
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GTN Side Effects |
Tachycardia Bradycardia (rare) Hypotension Skin flushing Headache |
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GTN Special Notes |
S/L effects: Onset: 30 seconds - 2 minutes Peak: 5 - 15 minutes Duration: 15 - 30 minutes Intravenous Onset: 30 seconds - 1 minute Peak: 3 - 5 minutes Duration: 15 - 30 minutes Transdermal effects Onset: Up to 30 minutes Peak: 2 hours |
