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24 Cards in this Set
- Front
- Back
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GHRH
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stimulates GH release
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dopamine
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stimulates GH release
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catecholamines
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stimulates GH release
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excitatory amino acids
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stimulates GH release
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thyroid hormone
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stimulates GH release
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hypoglycemia
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stimulates GH release
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somatostatin
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inhibits GH release
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IGF-1
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inhibits GH release
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Glucose
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inhibits GH release
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free fatty acids
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inhibits GH release
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When are levels of GH highest in human circulation?
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just after initiation of deep sleep
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what form of GH is found most readily in the body?
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bound to GH-binding protein
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half life of GH
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6-20 minutes, afterwards it is degraded in lysosomes
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stimulation of IGF-1 production is an example of a _______ effect of GH
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indirect
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most important physiologic effet of GH
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stimulation of postnatal longitudinal growth
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Where do you find GH receptors?
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liver, bone, kidney, AT, M, eye, brain, heart, and cells of immune system
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upon binding to the GH receptor, what is required for biologic activity?
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dimerization of receptor
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describe GH's activity over a human lifespan
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not active during gestation, begins gradually more so during 1st and 2nd years and peak at puberty, then trail off
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GH effect on AT
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metabolic, stimulates release and oxidation of free fatty acids
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GH effect on SM
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anabolic, take up of amino acids, stim of protein synth
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GH effect on liver
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production of IGF-1 and glucose
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GH relationship with insulin
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GH counteracts insulin; decrease in glu utilization, increase lipolysis, stim glu production
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What cells are responsible for GH production and storage
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somatotrophs of the anterior pituitary
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describe the function of IGF-1
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act as a mitogen, stim DNA, RNA, and protein synthesis. Mediates many of the growth and metabolic effects of GH
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