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25 Cards in this Set
- Front
- Back
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What are dose dependent toxicities for Na channel drugs?
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Diplopia, ataxia, lethargy
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useful against generalized seizures
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valproic acid, topiramate, zonisamide, levetiracetam
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myclonic seizures
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clonazepam
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act at alpha2delta subunit of voltage-gated calcium channel
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gabapentin and pregabalin
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bind to SV2A synaptic vesicle protein
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levetiracetam
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status epilepticus treatment
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lorazepam followed by iv fosphenytoin
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strongly induce cyp450
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carbamazepine, phenytoin, phenobarbital
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metabolized by UGT
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lamotrigine
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induce UGT
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valproic acid
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treat absence seizures
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ethosuximide
EFGH --> ethosuximide SEs: fatigue, GI irritation, headaches |
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enhance GABAergic inhibition
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benzodiazepines and barbiturates
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GABAergic agent SEs
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somnolence, confusion, memory disturbance
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Induces P450 enzyme that metabolizes itself
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carbamazepine
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Phenytoin SEs
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gingivial hyperplasia, osteoporosis, and neuropathy
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carbamazepine SEs and MOA
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rash, dose-dependent neutropenia, aplastic anemia
NA channel AED |
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lamotrigine SE and MOA
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rash and NA channel AED
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topiramate SE and MOA
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confusion and renal stones; NA channel AED
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zonisamide SE and MOA
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renal stones; NA channel AED
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oxcarbazepine SE and MOA
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hyponatremia; NA channel AED
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ethosuximide SE and MOA
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GI irritation, lethargy; T-type Calcium channel inhibitor
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valproic acid SE
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fat, shaky, yellow, and bald
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phenobarbital
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cognitive slowing, hyperactivity in kids
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gabapentin
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weight gain, somnolence, and ataxia
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pregabalin
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weight gain, peripheral edema, and dizziness
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Levetiracetam
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somnolence, psychosis
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