Study your flashcards anywhere!

Download the official Cram app for free >

  • Shuffle
    Toggle On
    Toggle Off
  • Alphabetize
    Toggle On
    Toggle Off
  • Front First
    Toggle On
    Toggle Off
  • Both Sides
    Toggle On
    Toggle Off
  • Read
    Toggle On
    Toggle Off
Reading...
Front

How to study your flashcards.

Right/Left arrow keys: Navigate between flashcards.right arrow keyleft arrow key

Up/Down arrow keys: Flip the card between the front and back.down keyup key

H key: Show hint (3rd side).h key

A key: Read text to speech.a key

image

Play button

image

Play button

image

Progress

1/28

Click to flip

28 Cards in this Set

  • Front
  • Back
what are the hematopoietic progenitors or grans/monos?
Pluripotent stem cell
CFU-GEMM
CFU-GEMM differentiates into:
CFU-GM
CFU-Eo
CFU-M
what are the cells in granulocytic maturation?
myeloblast
promyelocyte
myelocyte
metamyelocyte
band neutrophil
neutrophil
The neutrophils, eosinophils and basophil early cells are all pretty similar, until what point of start to differentiate?
-Metamyelocyte. Identify as granulocyte, eosinophilic, basophilic metamyelocyte
eosinophilic metamyelocyte becomes
basophilic
granulocytic
-eosinophil
-basophil then a mast cell
-PMN
so it's easy; it's a CFU-G then
myeloblast
neutrophilic metamyelocyte
PMN
what is the last stage of the myelocyte maturation capable of division?

this is before:
Myelocyte

before the metamyelocyte
which stage of maturation has a round nucleus in granulocytes?
MyelOCyte
which cell has half-diameter sized nucleus?
metamyelocyte
which cell has less than a half-diameter sized nucleus?
BAND - not kinked, but a nice horseshoe of nuclear material
what is the last stage of discernible nucleoli in myelocyte maturation?
Myelocyte
what is the DAWN OF THE NEUTROPHIL?
the myelocyte - the golgi apparatus making granules makes a pinkish halo around the nucleus.
what cell is the major turning point in granulocytic maturation?
the Myelocyte
what do nucleoli tell us?
the cell is capable of division
in which cell are granules first readily identifiable?
the promyelocyte - azurophilic granules that are RED.
between granulocytes, eosinos and basos, how do the following differ:
-Lobes of nucleus
-Granules
PMN has 2-5 lobes
Eosino has 0-2
Basos have 0-2

PMNs have many fine violet-pink granules
Eosinos: uniform distinct RED granules
Basos: non-uniform purple-black granules
what is the function of granulocytes?
to KILL MICROORGANISMS
How many neutrophils do we make per day?
Where are they made?
Make about 100 million/mg/day

They're made in the bone marrow
What are the 2 compartments of neutrophils in the bone marrow?
-Mitotic compartment - contains cells up to the Myelocyte.

-MAturation compartment - contains Metamyelocytes, Bands and Segs
How much of the total granulocytes we have is represented by the WBC count?
only 20%
How is the total circulating granulocyte pool broken down?
-Marginal Pool = 50%: hangs out at edges of vessels and adheres to endothelium so we don't count it.

-Circulating = 50%: what we count.
What is the half life of granulocytes before they go into the tissues?
7 hrs
How long do they stay in the tissues? 2-5 days
2-5 days
Would we normally see an increased neutrophil? why or why not?
yes - diurnally we have more later in day.

Stress increases, temperature, strenuous exercise
what are 5 pathologic causes of neutrophilia?
Infection
Hematologic disorder - Chronic Leukemia
Tissue breakdown
Drugs/toxins
Leukemoid reaction - TB, cancer
Why would we see a DECREASED neutrophils?
)2 reasons)
1. increased need - bacterial infection

2. diminished production - Aplastic anemia, cytotoxic drugs, hypersplenism, dmg hematopoietic environment
what is Agranulocytosis?
less than 500 cels/uL - patients can't function with this low of a count
What 3 neuts are capable of engulfing microorganisms? What's best?
Segs - best

Bands - okay

Metamyelocytes - not that great but are able to.