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28 Cards in this Set
- Front
- Back
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what are the hematopoietic progenitors or grans/monos?
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Pluripotent stem cell
CFU-GEMM |
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CFU-GEMM differentiates into:
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CFU-GM
CFU-Eo CFU-M |
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what are the cells in granulocytic maturation?
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myeloblast
promyelocyte myelocyte metamyelocyte band neutrophil neutrophil |
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The neutrophils, eosinophils and basophil early cells are all pretty similar, until what point of start to differentiate?
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-Metamyelocyte. Identify as granulocyte, eosinophilic, basophilic metamyelocyte
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eosinophilic metamyelocyte becomes
basophilic granulocytic |
-eosinophil
-basophil then a mast cell -PMN |
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so it's easy; it's a CFU-G then
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myeloblast
neutrophilic metamyelocyte PMN |
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what is the last stage of the myelocyte maturation capable of division?
this is before: |
Myelocyte
before the metamyelocyte |
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which stage of maturation has a round nucleus in granulocytes?
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MyelOCyte
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which cell has half-diameter sized nucleus?
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metamyelocyte
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which cell has less than a half-diameter sized nucleus?
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BAND - not kinked, but a nice horseshoe of nuclear material
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what is the last stage of discernible nucleoli in myelocyte maturation?
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Myelocyte
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what is the DAWN OF THE NEUTROPHIL?
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the myelocyte - the golgi apparatus making granules makes a pinkish halo around the nucleus.
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what cell is the major turning point in granulocytic maturation?
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the Myelocyte
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what do nucleoli tell us?
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the cell is capable of division
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in which cell are granules first readily identifiable?
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the promyelocyte - azurophilic granules that are RED.
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between granulocytes, eosinos and basos, how do the following differ:
-Lobes of nucleus -Granules |
PMN has 2-5 lobes
Eosino has 0-2 Basos have 0-2 PMNs have many fine violet-pink granules Eosinos: uniform distinct RED granules Basos: non-uniform purple-black granules |
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what is the function of granulocytes?
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to KILL MICROORGANISMS
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How many neutrophils do we make per day?
Where are they made? |
Make about 100 million/mg/day
They're made in the bone marrow |
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What are the 2 compartments of neutrophils in the bone marrow?
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-Mitotic compartment - contains cells up to the Myelocyte.
-MAturation compartment - contains Metamyelocytes, Bands and Segs |
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How much of the total granulocytes we have is represented by the WBC count?
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only 20%
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How is the total circulating granulocyte pool broken down?
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-Marginal Pool = 50%: hangs out at edges of vessels and adheres to endothelium so we don't count it.
-Circulating = 50%: what we count. |
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What is the half life of granulocytes before they go into the tissues?
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7 hrs
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How long do they stay in the tissues? 2-5 days
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2-5 days
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Would we normally see an increased neutrophil? why or why not?
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yes - diurnally we have more later in day.
Stress increases, temperature, strenuous exercise |
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what are 5 pathologic causes of neutrophilia?
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Infection
Hematologic disorder - Chronic Leukemia Tissue breakdown Drugs/toxins Leukemoid reaction - TB, cancer |
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Why would we see a DECREASED neutrophils?
)2 reasons) |
1. increased need - bacterial infection
2. diminished production - Aplastic anemia, cytotoxic drugs, hypersplenism, dmg hematopoietic environment |
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what is Agranulocytosis?
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less than 500 cels/uL - patients can't function with this low of a count
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What 3 neuts are capable of engulfing microorganisms? What's best?
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Segs - best
Bands - okay Metamyelocytes - not that great but are able to. |
