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41 Cards in this Set
- Front
- Back
Lethal toxin of Bordatella pertussis (Whooping Cough)
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Dermonecrotic toxin: local necrosis
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action of pertussis toxin
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ADP ribosylation of Gi; increased adenylate cyclase & cAMP
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3 stages of pertussis intoxication:
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Catarrhal, Paroxysmal (most infectious), Convalescent
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which one isn't characteristic of pertussis--increase in cGMP, hypoglycemia, increase in phagocytosis, increase in cAMP?
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increase in cGMP
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Growth rqs presence of Factors X (heme) and V (NAD)
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Hemophilus Influenza
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1 yr old infant w/ neck rigidity, seizures, Culture reveals Gram (-) bug that requires follows an URTI (strain B)and exhibits satellitism. Suspect?
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Hemophilus influenza
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Alcoholic w/ currant jeylly sputum, upper lobe inflammation, culture shows no motility. suspect?
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Klebsiella pneumoniae
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Virulence factor- monotricous flagella
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Legionella pneumophilia (Legionaires Disease)
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Has adhesions, invasions, flagella (motility/chemotaxis), exoenzyme S, exotoxin A, LPS, hemolysins, antiphagocytic properties (capsule, slime, LPS), Pyoverdin, has glycocalyx
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Pseudomonas aeruginosa
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Normal colonization of Bacteroides fragilis is found where?
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colon
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Normal colonization of Cornybacteria diptheria is found where?
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throat epithelium
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Coastal traveller presents with bloddy diarrhea. Culture shows Lac (+) bugs
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E. coli
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Coastal traveller presents with bloody diarrhea. Culture shows Lac (-) colonies. suspect?
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Shigella
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Bug that produces "traveller's diarrhea;" the famous Montezuma's revenge:
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E. coli--ETEC
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Bug that produces HUS, produces shiga-like toxin (verotoxin), and inhibits protein synthesis by attacking the 60S ribosome
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EHEC--E. coli 0157:H7
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epithelial invasive bacteria that produces shiga-like toxin and colonizes Lac (+).
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E. coli--EIEC
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Diagnosis of Enterobacteriaceae generalities:
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Eosin methylene blue (EMB) agar (inhibits Gram [+]), MacConkey agar (bile salts inhibit Gram [+])
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Virulence of Enterobacteriaceae generalities:
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Antigens O (outer LPS), K (capsule), & H (flagella)
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Virulence of Escherichia coli:
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K & H antigens, siderophores, adhesins, fimbriae (pili)
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Toxins of Escherichia coli:
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LT (cAMP), ST (cGMP), shiga-like toxin
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Treatment of Escherichia coli:
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Cephalosporins, aminoglycosides, trimethoprim & sulfamethoxazole, fluoroquinolones
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Treatment of Klebsiella pneumoniae:
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cephalosporin, ciprofloxacin
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Toxins of Shigella dysenteriae:
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shiga-toxin (inhibits 60S ribosome, protein synthesis)
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Treatment of Shigella dysenteriae:
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Fluoroquinolones, Trimethoprim & sulfamethoxazole, azithromycin
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Virulence of Vibrio cholerae:
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H antigen, mucinase, fimbriae, non-invasive
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Toxins of Vibrio cholerae:
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Choleragen (increases cAMP)
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Treatment for Vibrio cholerae:
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replace fluids, doxycycline, fluoroquinolone
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Diagnosis of Vibrio cholerae:
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Flat yellow colonies: thiosulfate-citrate-bile salt-sucrose agar (TCBS), dark fluid microscopy of stool
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Virulence of of Vibrio parahaemolyticus:
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H antigen, capsule
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Toxins of Vibrio parahaemolyticus:
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hemolytic cytotoxin
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Diagnosis of of Vibrio parahaemolyticus:
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thiosulfate & bile salts
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Treatment of Vibrio parahaemolyticus:
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Fluoroquinolone, Erythromycin
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Virulence of Campylobacter jejuni:
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H antigen, invasive
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Toxins of Campylobacter jejuni:
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enterotoxin, cytotoxin
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Treatment of Campylobacter jejuni:
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Fluoroquinolone, Erythromycin
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Diagnosis of Campylobacter jejuni:
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Microscopic Gram (-) curved motile rods, selective media at 42 degrees C.
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Treatment of H. pylori:
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Bismuth, ampicillin, metronidazole, and tetracycline; or clarithromycin and omeprazole
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Virulence of Pseudomonas aeruginosa:
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H antigen, hemolysin, collagenase, elastase, fibrinolysin, phospholipase C, DNAase, antiphagocytic capsule
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Toxins of Pseudomonas aeruginosa:
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Exotoxin A
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Treatment of Pseudomonas aeruginosa:
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Ticarcillin, Timentin, Carbenicillin, Piperacillin, Mezlocillin, Ciprofloxacin, Imipenem, Tobramycin, Aztreonam
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Diagnosis of Pseudomonas aeruginosa:
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fruity-smelling metallic green colonies on blood agar
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