Gram Negative Cocci

Front 1

Describe the important properties of neisseria

Back 1

Gram negative diplococci resembling a kidney bean. OXIDASE POSITIVE (NON LACTOSE FERMENTING)
N. Meningitis: polysaccharide capsule
N. Gonorrhoeae: pili for adhesion to genital and other MUCOSAL epithelium
Endotoxin (lipase A) Remember Gram negative!
IgA Protease (cleaves IgA Antibodies)

Front 2

Types of Neisseria

Back 2

Gonorrhoeae and Meningitis

Front 3

Important properties of Neisseria Meningitidis:

Back 3

REMEMBER polysaccharide capsule (antiphagocytic)

Front 4

Important properties of Neisseria Gonorrhea

Back 4

(think infection of genital epithelium and mucosal lining)
Presence of Pili (Pilus in the penis). Antigenicity based on pilus (no capsule)

Front 5

What inhibits growth of Neisseria

Back 5

Gram negative diploccoci that cannot be cultured on blood agar plate because they are inhibited by trace metals and fatty acids. Cultured on Chocolate Agar plates .

Front 6

What test can distinguish neisseria?

Back 6

Oxidase test neisseriae are oxidase positive (non lactose fermenting)

Front 7

Pathogenesis of Neisseria Meningitidis

Back 7

Carriers are usually asymptomatic (transiet flora of the NASOpharynx).
Polysaccharide capsue
Endotoxin (causes fever, shock)
IgA Protease

Front 8

What three bacteria cause over 80% of Meningitis?

Back 8

Haemoophilus influenzae
S. Pneumoniae
N. Meningitidis

Front 9

How can you be resistant to N Meningitidis (or any other capsular bacteria?)

Back 9

Opsonization (antibodies to capsule) due to vaccine or previous infection

Front 10

Clinical findings of Meningitidis?

Back 10

Meningitis or meningococcemia .

Front 11

How to distinguish N. Meningititis in lab?

Back 11

Again, gram negative cocci that are oxidase positive. Grows on chocolate agar. If you see gram negative cocci in CSF smear can assume N meningitidis.

Front 12

Pathogenesis of N. Gonorrhea?

Back 12

sexually transmitted and can infect newborns upon birth.
IgA protease
Pilli for adhesion (only pilli are virulent) and also antiphgocytic

Front 13

Clinical findings of N. Gonorrhea?

Back 13

localized infection in genital tract but can also occur in anorectal area and throat (adheres to mucosal lining)
can cause dysuria, and purulent discharge in men and women and cause intermenstrual bleeding in women.
In neonates, you can observe purulent conjectivitis.