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21 Cards in this Set

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what are the pathogenic mechanisms of Neisseria meningitidis?
pili, polysaccharide capsule, ENDOtoxin
pathogenic mechanisms of N. gonorrhoeae
pili, endotoxin, IgA protease
N. meningitidis commonly causes..
Epidemic Meningitis
Humans carry N. meningitidis via what route?
nasopharyngeal carriage
True or False: gonorrhea is usually symptomatic in most males
False (aymptomatic in most males)
O antigen of LPS serves what function?
facilitate adherence to human tissues

resistance to phagocytes

protection from antibodies

soluble carrier for lipid A

basis for serotyping
Characteristics of Neisseriaceae?
gram negative diplococci

distinct kidney bean shape

pyogenic (pus-producing)

DO NOT produce EXOtoxins

disease due to ability to resist phagocytosis
T or F: Endotoxin can be found in all gram positive bacteria
False
Members of Enterobacteriaceae?
E. coli

Shigella

Salmonella
Characteristics of E. coli?
Falculative gram negative rods
E. coli is the major cause of meningitis in whom?
Newborns
Virulence factors of E. coli:
ENTEROtoxins

pili

antiphagocytic capsule

hemolysin (lyses red blood cells)

ability to obtain iron from transferrin
4 classes of E. coli that cause gastroenteritis in humans?
Enterotoxigenic E. coli

Enterohemolytic

Enteropathogenic

Enteroinvasive
Enteropathogenic E. coli (EPEC) is known to cause what type of diarrhea?
Infantile Diarrhea (in newborns and young children, may result in death)
Enterotoxigenic E. coli (ETEC) commonly causes which type of diarrhea?
Traveler's Diarrhea
Which types of E.coli produce a Shiga-like toxin?
EHEC and EIEC
Key virulence factor of EIEC?
plasmid-encoded ability to invade epithelial cells lining the intestine
T or F: E. coli are the most common cause of urinary tract infections?
True
EIEC produces a disease that is indistinguishable from the disease produced by Shigella, which disease?
Bacillary dysentary
Shigella's multiple antibiotic resistance is mostly due to what?
Organisms ability to acquire plasmids
In what ways is Shigella and Enteroinvasive E. coli similar?
both produce a Shiga toxin (or shiga-like; EIEC)

both have same mechanism for invasion of intestinal epithelium (causes severe local inflammation response which results in bloody diarrhea)