Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
14 Cards in this Set
- Front
- Back
|
Drug of choice for acute gout
|
Indomethacin
|
|
|
how long should indomethacin be used?
|
until 24hrs after gout sxs resolve (5-8days total)
|
|
|
Colchicine MOA
|
antiinflammatory, inhibit leukocyte migration
NO analgesic effect |
|
|
Colchicine dosing
|
PO for acute gout
can also use every other day for prophylaxis |
|
|
Colchicine ADE
|
N/V/D
*must stop when GI sxs appear or will lead to bone marrow suppression |
|
|
caution colchicine use in pts:
|
renal (<10 CrCl)/hepatic insufficiency, PUD, spastic colon
|
|
|
Colchicine DI
|
decrease B12 absorb
EtOH: increase GI toxicity Erythromycin: Colch tox grapefruit juice |
|
|
Corticosteroid place in therapy for gout
|
reserved for resistant cases or pts with renal insufficiency who can't use other acute gout drugs
|
|
|
Prophylactic gout meds
|
allopurinol, febuxostat, uricosuric (probenecid), pegloticase (krystexxa)
|
|
|
which prophylactic gout meds are for over producers of UA?
|
allopurinol, febuxostat
|
|
|
which prophylactic gout meds are for under excretors of UA?
|
probenecid
|
|
|
allopurinol MOA
|
inhibits xanthine oxidase (decrease Serum UA)
|
|
|
What drug should be combined with all prophylactic gout therapy?
|
colchicine or NSAIDS to avoid acute gout attack with therapy initiation
|
|
|
Allopurinol DI?
|
cyclosporine and azathioprine are both metabolized by XO --> toxicity
|
