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16 Cards in this Set
- Front
- Back
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NSAID for Gout
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Indomethacin
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Indomethacin MOA
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Decreases PG
Inhibits crystal phagocytosis by MO Decreases inflammatory mediators in joint |
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Indomethacin SE
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Impaired renal func
Ulcers Vertigo limits dosing in gout |
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2 Drugs used for ACUTE gout
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Indomethacin
Colchicine (2nd line) |
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Colchicine Class
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Microtubule inhibitor
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Colchicine Action
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Anti-inflammatory
Anti Histamine Anti-phagocytic Decrease LTB4 production |
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Colchicine MOA
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Binds tubulin--> interferes w/ mitotic spindles--> depolymerization--> inhibits migration of granulocytes to inflammation!
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Colchicine SE
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Diarrhea
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Xanthine Oxidase Inhibitors for Gout
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Febuxostat
Allopurinol |
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Inhibits Xanthine Oxidase which prevents conversion of hypoxanthine--> xanthine-->uric acid
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Febuxostat
Allopurinol |
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Allopurinol SE
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May precipitate gouty arthritis
Rash when given w/ ampicillin |
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Uricosuric Agents in Gout
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Probenacid
Sulfinpyrazone |
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Probenacid Action
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Increases uric acid excretion usually
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Sulfinpyrazone Action
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Increases uric acid excretion like Probenacid BUT also an anti-platelet!!
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Uricosuric Agents MOA
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Both probenacid and sulfinpyrazone are weak acids that compete w/uric acid for reabsorption in prox tubules
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Probenacid SE
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Increase Serum penicillin (PCN)
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