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19 Cards in this Set
- Front
- Back
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Major ovarian estrogen in women
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Estradiol
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When used as HRT, estrogen increases the risk of
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Endometrial cancer
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Dose dependent toxicity of estrogen includes
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nausea, breast tenderness, increased risk of migraines, thromboemblic events, gallbladder disease, hypertriglyeridemia, hypertension
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Major progestin in humans
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progesterone
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Toxicities of progestins
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Increased BP and decrease HDL
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Major toxic effect of OC
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Thromboembolism
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SERM stands for
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Selective Estrogen Receptor Modulator
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Antagonist for breast tissue, agonist for bone; treating breast CA and preventing osteoporosis
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Tamoxifen
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SERM with no endometrial action
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Raloxifene
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Selectively blocks estrogen receptors in the pituitary; reducing - feedback and increasing FH and LSH output
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Clomiphene
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Post-coital abortient
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Mifepristone (RU 486)
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Used in the tx of endometriosis and fibrocystic change of the breast
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Danazol
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Aromatase inhibitors
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Anastozole and letorzole
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Used to promote weight gain in patients with wasting syndromes
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Androgens
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Competitive antagonists at androgen receptors
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Flutamide
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Used in the treatment of hirsutism
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Spironolactone
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Gonadotropin releasing hormone
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Leuprolide
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5 alpha-reductase inhibitor
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finasteride
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Inhibitors of steroid synthesis
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Ketoconazole
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