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19 Cards in this Set

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Major ovarian estrogen in women
Estradiol
When used as HRT, estrogen increases the risk of
Endometrial cancer
Dose dependent toxicity of estrogen includes
nausea, breast tenderness, increased risk of migraines, thromboemblic events, gallbladder disease, hypertriglyeridemia, hypertension
Major progestin in humans
progesterone
Toxicities of progestins
Increased BP and decrease HDL
Major toxic effect of OC
Thromboembolism
SERM stands for
Selective Estrogen Receptor Modulator
Antagonist for breast tissue, agonist for bone; treating breast CA and preventing osteoporosis
Tamoxifen
SERM with no endometrial action
Raloxifene
Selectively blocks estrogen receptors in the pituitary; reducing - feedback and increasing FH and LSH output
Clomiphene
Post-coital abortient
Mifepristone (RU 486)
Used in the tx of endometriosis and fibrocystic change of the breast
Danazol
Aromatase inhibitors
Anastozole and letorzole
Used to promote weight gain in patients with wasting syndromes
Androgens
Competitive antagonists at androgen receptors
Flutamide
Used in the treatment of hirsutism
Spironolactone
Gonadotropin releasing hormone
Leuprolide
5 alpha-reductase inhibitor
finasteride
Inhibitors of steroid synthesis
Ketoconazole