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237 Cards in this Set

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Mallory bodies. Hyaline (eosinophilic) inclusions (arrow) are present in the cytosol of hepatocytes.
.
A and B, Right-sided Bell's palsy showing inability to fully close the eye and drooping of the corner of the mouth
.
Acid-fast stain of a lung biopsy in a patient with reactivation tuberculosis due to Mycobacterium tuberculosis
.
Acoustic neuroma showing spindle-shaped cells with alternating dark and light areas
.
Bronchopneumonia showing patchy areas of consolidation
.
Cerebellum in a patient with rabies showing Purkinje cells with intracytoplasmic, eosinophilic inclusions (arrows) called Negri bodies
.
Common systemic fungal infections. The yeast form of Cryptococcus neoformans (A) produces a narrow-based bud (arrow). Coccidioides immitis (B) has spherules containing endospores (arrows). Multinucleated giant cells
.
Dependent pitting edema showing depressions in the skin around the ankle. Pitting edema is due to an increase in vascular hydrostatic pressure or a decrease in vascular oncotic pressure (hypoalbuminemia)
.
Dermatographism
.
Diffuse membranous glomerulonephritis. The H[amp ]E (hematoxylin [amp ] eosin)-stained biopsy (A) shows glomerular basement membranes that are uniformly thickened. There is no proliferative component. The silver stain
.
Diffuse type of gastric adenocarcinoma with signet-ring carcinoma cells (arrows)
.
Electron micrograph of a type II pneumocyte showing lamellar body (arrow) containing surfactant
.
Embryonated eggs of Enterobius vermicularis
.
Metastatic renal cell carcinoma showing multiple nodular lesions scattered throughout the lung parenchyma
.
Fibroadenoma
.
Mallory bodies. Hyaline (eosinophilic) inclusions (arrow) are present in the cytosol of hepatocytes
.
Fatty change of the liver
.
Hydronephrosis of the kidney. There is marked dilation of the renal pelvis and calyces with thinning of the overlying cortex and medulla due to compression atrophy
.
. Left ventricular hypertrophy
.
.Benign prostatic hyperplasia
.
Intestinal metaplasia of the gastric mucosal epithelium in chronic gastritis
.
Squamous dysplasia of the cervix, a precursor of squamous cell carcinoma..jpg
.
Acute myocardial infarction (MI) showing coagulation necrosis.
.
Acute myocardial infarction (MI) showing a pale infarction of the posterior wall of the left ventricle (bottom left)
.
Hemorrhagic infarction of the lung. There is a roughly wedge-shaped area of hemorrhage.jpg
.
Dry gangrene of the toes
.
Cerebral infarction showing liquefactive necrosis
.
Caseous granuloma showing a central area of acellular, necrotic material surrounded by activated macrophages (epithelioid cells), lymphocytes, and multiple multinucleated Langhans-type giant cells
.
Enzymatic fat necrosis in acute pancreatitis
.
Apoptosis in the epidermis. The arrow shows a clear space in the epidermis containing an intensely eosinophilic staining cell with a small, dense nucleus.
.
Signs of acute inflammation. The patient has erysipelas of the face due to group A streptococcus. Signs of acute inflammation that are present in the photograph include redness (rubor) and swelling (tumor)
.
Acute inflammation. Histologic section of lung in bronchopneumonia showing sheets of neutrophils with multilobed nuclei.
.
Purulent (suppurative) inflammation. The photograph shows a skin abscess (furuncle) due to Staphylococcus aureus. Abscesses are pus-filled nodules located in the dermis.
.
Fibrinous inflammation. The epicardial surface of the heart is covered by a shaggy layer of fibrin material
.
Pseudomembranous inflammation. There is necrosis and a yellow-colored exudate covering the mucosal surface of the colon due to a toxin produced by Clostridium difficile.
.
Chronic inflammation. This tissue shows an infiltrate of predominantly plasma cells (cells with eccentric nucleus and perinuclear clearing) and lymphocytes
.
Ehlers-Danlos syndrome
.
Keloid formation
.
Absolute leukocytosis with left shift. Arrows point to band (stab) neutrophils, which exhibit prominence of the azurophilic granules (toxic granulation). Vacuoles in the cytoplasm represent phagolysosomes
.
Malar rash in systemic lupus erythematosus showing the butterfly-wing distribution
.
Systemic sclerosis. The tightening of the skin around the mouth is caused by excess collagen.
.
Kaposi's sarcoma in HIV. Skin lesions are raised, red, and nonpruritic
.
Patient with signs of volume the mucosal surface of the tongue is dry. Additional findings on examination were hypotension, tachycardia, and decreased skin turgor. (From Forbes C, depletion
.
Electrocardiogram showing hyperkalemia. Arrows show peaked T waves, which are a sign of hyperkalemia.
.
Coronary artery thrombosis. In this specially stained cross-section of a coronary artery, collagen is blue and the thrombus is red
.
Pulmonary embolus. The main branches of the pulmonary artery are occluded with large-caliber thromboemboli (saddle emboli)
.
Down syndrome. The facial profile (A) shows a short stature, small head with small nose and ears. The hand (B) shows a single palmar (simian) crease
.
Turner's syndrome is characterized by a webbed neck
.
Klinefelter's syndrome
.
Prader-Willi syndrome
.
Angelman syndrome
.
Testicular feminization. The patient is genotypically male, but phenotypically female
.
Black widow spider
.
Brown recluse spider
.
Kwashiorkor and marasmus. Left, Child with kwashiorkor, showing dependent pitting edema involving the lower legs. Right, Child with marasmus, showing broomstick extremities with loss of muscle mass and sub
.
Anorexia nervosa
.
Gums showing the effects of scurvy
.
Tubular adenoma (adenomatous polyp) of the colon showing a fibrovascular stalk
.
Lipoma showing a well-circumscribed yellow tumor (A) containing benign adipose cells (B)
.
Cystic teratoma of the ovary,
.
.Figure 8-4 Squamous cell carcinoma. The many well-differentiated foci of eosinophilic-staining neoplastic cells produce keratin in layers (keratin pearls)..jpg
.
Adenocarcinoma. Irregular glands infiltrate the stroma
.
Osteogenic sarcoma of the distal femur. The light-colored mass of tumor in the metaphysis abuts the epiphyseal plate (arrow)
.
Metastasis to the liver. The liver contains multiple nodules that have a depressed central area (umbilicated)
.
Basal cell carcinoma (invasive tumor that does not metastasize)
.
Malignant melanoma. The lesion on the patient's forearm is black, is multinodular, and has an irregular border with areas of pale-gray discoloration
.
Xanthelasma. Yellow, raised lesions are noted on the eyelids in both eyes
.
Hyaline arteriolosclerosis
.
Abdominal aortic aneurysm
.
Henoch-Schönlein purpura
.
Acute myocardial infarction (day 7) in the posterior wall of the left ventricle
.
Fibrinous pericarditis. The surface of the heart is covered by a shaggy, fibrinous exudate
.
Left ventricular aneurysm. The bulging aneurysm has a thin wall of scar tissue
.
Acute rheumatic fever. Uniform, verrucoid-appearing sterile vegetations appear along the line of closure of the mitral valve
.
Mitral valve prolapse. The arrow shows prolapse of the posterior mitral leaflet into the left atrium
.
Aortic stenosis
.
Acute bacterial endocarditis
.
Myocarditis. The biopsy shows a lymphocytic infiltrate with dissolution of myocardial fibers
.
Peripheral blood reticulocytes with supravital stain (new methylene blueView drug information). Red blood cells with thread-like material in the cytosol represent residual RNA filaments and protein (arrow
.
Peripheral blood smear in iron deficiency anemia. The enlarged central area of pallor in the red blood cell (arrow) indicates a decrease in hemoglobin synthesis,
.
Ringed sideroblasts in a bone marrow aspirate. Dark blue iron granules around the nucleus of developing normoblasts (arrows) represent iron trapped within mitochondria and indicate a defect in mitochondri
.
Peripheral blood with coarse basophilic stippling of RBCs in lead poisoning. Note the mature RBC containing numerous dots representing ribosomes (arrow)
.
Peripheral blood in megaloblastic anemia showing the hypersegmented neutrophil (arrow) with nine lobes
.
Peripheral blood with spherocytes in hereditary spherocytosis. Numerous, round, dense red blood cells (RBCs) without central areas of pallor represent spherocytes (arrows). The mean corpuscular hemoglobi
.
Peripheral blood with sickle cells and target cells, showing the dense, boat-shaped sickle cells. Cells with a bull's-eye appearance are target cells (arrows), which have excess RBC membrane that bulges
.
Peripheral blood with sickle cells and Howell-Jolly bodies. The three dense boat-shaped sickle cells and the two cells containing a single dark, round inclusion (arrows) represent nuclear remnants. Howel
.
Peripheral blood with schistocytes. The fragmented red blood cells (RBCs) with absence of central pallor, schistocytes, are produced when RBCs are mechanically injured by calcium deposits in an aortic valve
.
Plasmodium falciparum ring forms in red blood cells (RBCs). This RBC has two ring forms. Multiple infestation of an RBC is characteristic of P. falciparum malaria
.
Leukoerythroblastic reaction. Numerous bone marrow reticulocytes with a blue discoloration
.
Peripheral blood with atypical lymphocyte. The cell shows prominent nucleoli and coarse nuclear chromatin. The cytoplasm is abundant and is indented by adjacent red blood cells
.
Peripheral blood in chronic myelogenous leukemia. Marked leukocytosis shows neutrophils at different stages of development (segmented and band neutrophils, metamyelocytes and myelocytes)
.
Peripheral blood with promyelocyte filled with Auer rods in acute promyelocytic leukemia
.
Peripheral blood in chronic lymphocytic leukemia
.
Gaucher disease
.
Niemann-Pick disease
.
Senile purpura
.
Laryngeal squamous cell carcinoma
.
Asbestos body
.
Malignant mesothelioma
.
Sarcoid granuloma
.
Chest radiograph in emphysema
.
Primary lung cancer
.
Small cell carcinoma of the lung
.
Oral thrush
.
Hairy leukoplakia along the lateral.
.
Leukoplakia of the tongue
.
.Barrett's esophagus
.
. Esophageal varices
.
. Gastric adenocarcinoma
.
.Entamoeba histolytica trophozoites
.
. Celiac disease
.
.Dermatitis herpetiformis
.
Hemorrhagic infarction
.
. Meckel diverticulum
.
. Sigmoid diverticulosis
.
. Ulcerative colitis.
.
. Crohn's disease
.
Tubular adenoma
.
. Familial polyposis
.
. Acute appendicitis
.
. Centrilobular hemorrhagic necrosis
.
Alcoholic cirrhosis
.
. Spider angioma (telangiectasia)
.
.Kayser-Fleischer ring.
.
.Hepatocellular carcinoma
.
. Yellow cholesterol stones
.
.Black pigmented stones
.
. Adult polycystic kidney disease
.
Normal glomerulus
.
.Subepithelial immunocomplex
.
.Red blood cell cast in the urine
.
. Crescentic glomerulonephritis
.
. Fatty cast under polarization
.
. Diabetic glomerulosclerosis
.
.Acute pyelonephritis.
.
.Waxy cast in the urine sediment
.
. Benign nephrosclerosis
.
.Renal cell carcinoma
.
Benign prostatic hyperplasia
.
.Prostate cancer. Arrow
.
A, Candida.
B, Chlamydia trachomatis. C, Gardnerella vaginalis. D, Herpes type
E, Herpes type 2.
F, Human papillomavirus.
.
G, Neisseria gonorrhoeae.
H, Treponema pallidum.
I, Treponema pallidum.
J, Trichomonas vaginalis.
.
.Extramammary Paget's disease
.
.Squamous cell carcinoma of cervix
.
.Polycystic ovarian syndrome
.
.Simple hyperplasia of endometria.jpg
.
. Endometrial carcinoma
.
.Leiomyomas.
.
. Ruptured ectopic tubal pregnancy
.
.Complete hydatidiform mole
.
.Ductal carcinoma in situ (DCIS)
.
.Lobular carcinoma in situ
.
.Infiltrating ductal carcinoma.
.
.Paget's disease of the breast
.
.Acromegaly showing the patient
.
. Primary hypothyroidism
.
Graves' disease
.
Papillary carcinoma of thyroid.
.
.Patient with Cushing syndrome
.
.Osteoporosis of vertebral column
.
.Rheumatoid arthritis
.
.Tophi (arrows)
.
.Erythema chronicum migrans
.
.Verruca vulgaris (common wart)
.
.Molluscum contagiosum
.
.Erythema infectiosum
.
.Varicella infection of skin
.
Impetigo of the face
.
. Patient with severe facial acne
.
.Acne rosacea
.
. Tinea versicolor.
.
. Lymphocutaneous sporotrichosis
.
.Contact dermatitis.
.
.Actinic (solar) keratosis
.
Lichen planus showing flat-topped
.
.Psoriasis involving the elbow
.
.Nail changes in psoriasis
.
. Pityriasis rosea
.
. Erythema multiforme
.
. Erythema nodosum
.
. Granuloma annulare.
.
. Acanthosis nigricans
.
.Solar lentigo
.
. Seborrheic keratosis on the breast
.
. Compound nevus
.
.Lentigo maligna melanoma
.
.Anencephaly
.
. Neurofibromatosis
.
.Epidural hematoma
.
.Subdural hematoma
.
.Atherosclerotic stroke.
.
.Embolic stroke
.
. Intracerebral hemorrhage
.
.Bacterial meningitis
.
. Cerebral abscess
.
.Fusion of the podocytes. Arrowheads show fusion of the podocytes, which should be separated by slit pores. This finding occurs in all glomerular diseases that present with the nephrotic syndrome (e.g., minimal change
.
.Gram stain of Streptococcus pneumoniae. The sputum stain shows numerous lancet-shaped diplococci
.
.Granular immunofluorescence. Granular irregular deposits in the capillaries are caused by immunocomplex deposition (e.g., poststreptococcal glomerulonephritis
.
. brain of a newborn with kernicterus. Arrows depict yellow bilirubin pigment deposited in the basal ganglia
.
.Herpes zoster
.
.Huntington disease. Coronal section (A) shows a dilated lateral ventricle and atrophy of the caudate, putamen, and globus pallidus when compared with a normal coronal section (B)
.
.If the crystal is blue when parallel to the slow ray, the crystal demonstrates positive birefringence.
.
.Normal peripheral blood smear showing RBCs. The RBCs are uniform in size, and the central areas of pallor are slightly less than half the total diameter of an RBC. The four dark objects (arrows) outside
.
. Giardia lamblia with two nuclei
.
. Man with ankylosing spondylitis
.
.Keratoacanthoma
.
classic Reed-Sternberg (RS) cell. The large, multilobed cell with prominent nucleoli is surrounded by a halo of clear nucleoplasm. Classic RS cells are more easily found in mixed-cellularity Hodgkin's lymphoma
.
.Linear immunofluorescence. The uninterrupted smooth immunofluorescence along the glomerular basement membrane is caused by deposition of IgG antibodies directed against the membrane (e.g., Goodpasture syndrome)
.
.Liver biopsy stained with Prussian blue in a patient with hereditary hemochromatosis
.
.Lung biopsy stained with Gomori methenamine-silver showing septated hyphae and fruiting body (inset) of Aspergillus fumigatus
.
.Malignant plasma cells in multiple myeloma. The majority of malignant plasma cells show a gray-blue cytoplasm, peripherally located nuclei, and perinuclear clearing
.
.Multiple sclerosis showing multiple areas of demyelinated white matter (arrows pointing to brown plaques)
.
analgesic nephropathy showing multiple brownish necrotic papillae (arrows)
.
.Neonatal respiratory distress syndrome
.
.Neurocysticercosis showing multiple cysts between the gray and white matter
.
.Optic disk with papilledema showing loss of the disk margin and hard exudates (white streaks
.
.Osteoarthritis. Bony protuberances (Heberden's nodes)
.
.Patient with myasthenia gravis showing ptosis of the left eye (A) followed by opening of the eye (B) after intravenous injection of Tensilon.
.
.Petechiae in idiopathic thrombocytopenic purpura showing pinpoint hemorrhages, a sign of platelet dysfunction
.
.Pneumocystis jiroveci pneumonia. This silver-impregnated cytologic smear
.
.Poststreptococcal diffuse proliferative glomerulonephritis
.
.Potassium hydroxide preparation of skin scrapings showing hyphae and yeasts
.
.Prostate cancer metastatic to the vertebral column. Multiple white foci of metastatic prostate cancer produce an osteoblastic response in the bone.
.
.Radiograph of a skull showing multiple punched out lytic lesions in multiple myeloma
.
.Radiograph showing small bowel obstruction.
.
.Saddle embolus occluding the main branches of the pulmonary artery
.
.Senile plaque (arrow) shows an eosinophilic center with peripherally located distended neuronal processes (neurites).
.
.Silver stain showing Helicobacter pylori organisms.
.
.Spongiform encephalopathy in Creutzfeldt-Jakob disease showing classic bubbles and holes of the neuropil cell bodies
.
.Subendothelial immunocomplex deposits viewed with electron microscopy.
.
.Substantia nigra in a patient with Parkinson disease (A) and a normal individual (B)
.
.Tinea capitis due to Trichophyton tonsurans
.
.Tinea corporis showing annular lesions with erythematous margins and clear centers
.
.subnuclear vacuoles (arrows) containing mucin push the nuclei of the endometrial cells toward the apex of the cell
.
Wernicke's encephalopathy showing hemorrhage and discoloration of mamillary bodies and the wall of the third ventricle
.
Wilson's disease showing cavitary necrosis of the putamen on both sides of the brain
.
cytomegalovirus. The enlarged nuclei of many of the type I pneumocytes contain large inclusions
.