Goljan Path Associations

Front 1

Goljan Path

Moblitz I

Back 1

Usually due to inferior MI. Rarely goes into 3rd degree block.

Txt w/Atrophine or Isoproterenol

Front 2

Goljan Path

Moblitz II

Back 2

BBB association.

Often goes to 3rd degree AV block

Usually due to anterior MI.

Front 3

Goljan Path

P wave

Back 3

Atrial depol

Front 4

Goljan Path

a wave

Back 4

LA contraction

Front 5

Goljan Path

T wave

Back 5

Vetricular repol

Front 6

Goljan Path

Wavy fibers

Back 6

Eosinophilic bands of necrotic myocytes.

Early sign of MI.

Front 7

Goljan Path

Janeway's lesions

Back 7

Acute bacterial endocarditis
Nontender, erythematous lesions of palms & soles

Front 8

Goljan Path

Osler's nodes

Back 8

Subacute bacterial endocarditis

Tender lesions of fingers & toes

Front 9

Goljan Path

Thiamine defcy

Back 9

Wet Beri Beri heart. Dilated (congested) cardiomyopathy due to chronic alcohol consumption.
Dyr Beri Beri = peripheral neuropathy
Wernicki-Korsakoff=ataxia; confusion;
confabulation;
memory loss

Front 10

Goljan Path

Fibrinous Pericarditis

Back 10

Associated w/MI: Dressler's

Front 11

Goljan Path

Serous Pericarditis

Back 11

Associated w/nonbacterial
viral (Coxsakie) infection
immunologic reaction

Front 12

Goljan Path

Friction Rub

Back 12

Pericarditis association

Front 13

Goljan Path

Hemorrhagic Pericarditis

Back 13

Associated w/ TB or neoplasm

Front 14

Goljan Path

Restrictive Cardiomyopathy

Back 14

Aka infiltrative cardiomyopathy that stiffens the heart
Due to amyloidosis in the elderly
Due to, also see schaumann & asteroid bodies in young(over 25 yoa)

Front 15

Goljan Path

PML's infectious agent

Back 15

JC Virus (Papovavirus=dsDNA, naked icosahedral capsid)

Front 16

Goljan Path

Edema

Back 16

Increased Pc (more seeps out)

Decreased pie c (less reabsorbed)

Increased permeability

Bloack lymphatic drainage

Front 17

Goljan Path

Adult Adult Polycrystic Kedney Disease

Back 17

Commonly see liver cysts & Berry aneurysmns along w/kidney cysts. Hematuria & HTN also present.

3 cysts in ea. Kidney w/+family history confirms diagnosis

Front 18

Goljan Path

Malignant HTN & Kidneys

Back 18

Petehial hemorrhages are seen on kidney surfaces = Flea-Bitten surface = young black men

Front 19

Goljan Path

Nephritic signs

Back 19

Hematuria

RBC casts

HTN

Front 20

Goljan Path

Hephrotic signs

Back 20

Proteinuria

Hypoalbuminemia

Edema

Front 21

Goljan Path

Podocyte Effacement seen w/

Back 21

Minumal Change (Lipoid nephrosis) disease

Front 22

Goljan Path

ASO seen in

Back 22

Acute post-streptococcal GN (due to betaHGASrtep)

Anti Streptolysin O

Front 23

Goljan Path

Crescentic GN

Back 23

Rapidly progressive GN - nephritic syndrome

Associated w/multi system disease or post-strep/post infectious glomerular nephritis

Front 24

Goljan Path

Hereditary Nephritis

Back 24

Alport's syndrome. X linked

Renal disease w/deafness & ocualr abnormalities

Front 25

Goljan Path

Membranoproliferative GN

Back 25

Can be secondary to complement deficiency; chronic infections; CLL

See tram tracking

Front 26

Goljan Path

TypeI Membrano Proliferative GN deposits

Back 26

C3 & IgG deposits

Front 27

Goljan Path

TypeII Membrano Proliferative GN deposits

Back 27

Only C3 deposits

Aka Dense deposit disease

Front 28

Goljan Path

Focal segmental glomerulosclerosis deposits

Back 28

IgM & C3 deposits

Front 29

Goljan Path

Cold agglutnins

Back 29

Seen in atypical pneumonia

It is IgM Ab with specificity for I Ag on adult RBCs

Front 30

Goljan Path

Scrofula

Back 30

TB in the lymph nodes

Front 31

Goljan Path

Aspirin-Asthma Triad

Back 31

Nasal polyps -

Rhinitis -

bronchoconstriction

Front 32

Goljan Path

Ferruginous badies

Back 32

Hemosiderin (pigment w/Fe3) covered magrophages that have been pahgocytised

Front 33

Goljan Path

Pancoast's tumar causes

Back 33

Ulnar nerve pain & Horner's syndrome

Front 34

Goljan Path

Fatty degeneration

Back 34

Made up primarily of triglycerides

Most commonly due to alcoholism which commonly leads to hepatic cirrhosis

Associated w/ CCl4

Front 35

Goljan Path

Cloudy swelling

Back 35

Failure of cellular Na pump

Seen in Fatty degeneration of the liver & in Hydropic(Vacuolar) degeneration of the liver

Front 36

Goljan Path

Hydropic degeneration

Back 36

Severe form of cloudy swelling

Seen with hypokalemia induced by vomitting/diarrhea

Front 37

Goljan Path

Liquefaction necrosis

Back 37

Rapid enzymatic break down of lipids

Seen commonly in Brain & Spinal cord (CNS) injuries

Seen in suppurative infections=pus formation

Front 38

Goljan Path

Coagulation necrosis

Back 38

Result of sudden ischemia

Seen in organs w/end arteries limited collateral circulation) = heart, lung, kidney, spleen

Front 39

Goljan Path

Caseation necrosis

Back 39

Combination of both coagulation & liquefaction necrosis

Seen w/M. tuberculosis & Histoplasma capsulatum infection

Front 40

Goljan Path

Fibrinoid necrosis

Back 40

Seen in the walls of small arteries

Associated w/malignant hypertension, polyarteritis nodosa, immune mediated vasculitis

Front 41

Goljan Path

Fat necrosis

Back 41

Result of lipase actions liberated from pancreatic enzymes

Seen w/Acute pancreatitis = saponification results

Front 42

Goljan Path

Hemoptysis

Back 42

Blook in sputum

Front 43

Goljan Path

Pulmonary embolism

Back 43

Most commonly thrombus from lower extremity vein

Front 44

Goljan Path

Phlebothrombosis

Back 44

From a vein of lower extremities, of a pregant uterus, in Congestive heart failer, bed ridden pt

As a complicaiton in a pt w/Pancreatic CA due to increased d blook coagulability

Front 45

Goljan Path

Saddle embolus

Back 45

Embolus lodged in bifurcation of pulmonary trunks

Increased RV strain = RV & RA dilate = Acute cor Pulmonale

Front 46

Goljan Path

Paradoxical embolism

Back 46

Right to Left shunt allose a venous embolism to enter arterial circulation

Patent ovale foramen or Atrial septal defect

Front 47

Goljan Path

Tuberculoid granuloma

Back 47

Collection of macrophages w/o caseation

Seen w/Sarcoidosis (non-caseating); Syphilis; Brucellosis & Leprotic infections

Front 48

Goljan Path

Cellulitis

Back 48

Spreading infection due to streptococcus

Front 49

Goljan Path

PSA

Back 49

Prostate Specific Antigen = elevated in prostatic CA

Front 50

Goljan Path

Increased 5-HT

Back 50

In cases of metastatic carcinoid, txt w/ Methysergide (5HT antagonist)

Front 51

Goljan Path

Increased aFeto Protein

Back 51

Hepatocarcinoma


Neural tub defects

Front 52

Goljan Path

CEA

Back 52

Carcinoembryonic Antigen - elevated in Colon CA

Front 53

Goljan Path

Chromosome 13

Back 53

Retinoblastoma

Front 54

Goljan Path

Chromosome 11p

Back 54

Wilms tumor of the kidney

Front 55

Goljan Path

Vinyl Chloride

Back 55

Associated w/ Angiosarcoma of the liver

Front 56

Goljan Path

Agent Orge

Back 56

Contains dioxin

Implicated as a cause of Hodgkin's disease, non-Hodgkin's lymphoma & soft tissue sarcomas

Front 57

Goljan Path

Parasites & CA

Back 57

Schistosoma haematobium = Urinary bladder CA

S.mansoni- Colon CA

Aspergillus flavus = potent hepatocarcinogen

Front 58

Goljan Path

Ochronosis

Back 58

Alkaptonuria
Error in tyrosine metabolism due to Homogentisic acid (oxidizes tyrosine)
Involving intervertebral disks = Ankylosing Spondilitis = Poker spine
See dark urine; dark coloration of sclera, tendons, cartilage

Front 59

Goljan Path

Lead poisoning

Back 59

Acid fast inclusion bodies
Increased urinary coproprophyrin
Anemia: microcytic/ hypochromic
Stippling of the basophils
Gingival line & lead line in bones: x-ray
Mental retadation

Front 60

Goljan Path

Heroin OD, clinically

Back 60

Massive pulmonary edema w/ frothy fluid from the nostrils

Front 61

Goljan Path

Fetal alcohol syndrome

Back 61

Small head,
small eyes,
funnel chest,
ASD,
Mental deficiency,
hirsutism

Front 62

Goljan Path

Atypical mycobacterium

Back 62

M. kanasasii & M.avium intracellulare

Front 63

Goljan Path

Cold abscesses

Back 63

Liquefied TB lesions similar to pyogenic abscesses but lacking acute inflammation

Front 64

Goljan Path

Actinomyces isrealli

Back 64

Farmers infection

Lumpy jaw (from chewing grain) & PID (IUD), but most common is due to saprophyticus

Front 65

Goljan Path

Congenital Syphilis

Back 65

Saddle nose,

Saber shin,

Hutchinson's teeth,

nerve deafness,

interstitial keratitis

Front 66

Goljan Path

Warthin-Finkeledy cells

Back 66

Reticuloendothelial giant cells on tonsis, lymph nodes, spleen

Seen with Rubeola (measles) due to paramyxovirus

Front 67

Goljan Path

Diphyllobothrium latum

Back 67

Tapeworm infection causing megaloblastic anemia by consuming large amoutn of vit B12 in the host

Front 68

Goljan Path

Subacute Bacterial Endocarditis

Back 68

alpha Hemolytic Streptococci (S. Viridans) = usually in pt w/pre-existing heart problem

Front 69

Goljan Path

Acute Bacterial Endocarditis

Back 69

Staph aureus, beta Hemolytic Streptococci, E. coli

Common among drug addicts & diabetics

Front 70

Goljan Path

Mitral Insufficiency

Back 70

Ruptured papillary muscle

Front 71

Goljan Path

Left Anterior Descending branch

Back 71

Branch of the Left Coronary artery

Highest frequency of thrombotic occlusion

MI=anterior wall of the LV, especially in apicalpart of interventricular septum

Front 72

Goljan Path

Left Circumflex branch

Back 72

Branch of the Left Coronary artery

Occlusion = MI of posterior/lateral wall of the LV

Front 73

Goljan Path

Dissecting Aneurysm

Back 73

False aneurysm: it is splitting of the media of the aorta
Usually accompanied w/long history of severe hypertension, also seen w/familial hyperlipidemia, atherosclerotic disease, Marfan's Collagen disease
Zones of medial necrosis +/- slitlike cysts=Medial Cystic Necrosis of Erdheim

Front 74

Goljan Path

Cor pulmonale

Back 74

Right ventricular strain, associated w/right ventricular hypertrophy

Front 75

Goljan Path

Acute Cor Pulmonale

Back 75

Sudden right ventricular strain due to a massive pulmonary embolism

Front 76

Goljan Path

Bronchopneumonia

Back 76

Lobular (rather than lobar)

Due to Staph aureus; Pseudomonas aeruginosa; Klebsiella; E. coli

Abscess formation is common

Front 77

Goljan Path

Lobar pneumonia

Back 77

Due to Strep. Pneumoniae infection (5% due to Klebsiella)
Red Hepatization: days 1-3 of the pneumonia
Gray Hepatization: days 3-8 of untreated pneumonia
Complications:pleural effusion: atelectasia; fibrinous pleuritis; empyema; fibrinous pericarditis; otitis media

Front 78

Goljan Path

Bronchiectasis

Back 78

Permanent dialation of the bronchi - predisposed by chronic sinusitis & post nasal drip

Supparation associated

Lower lobe > than upper lobe involvement

Front 79

Goljan Path

Cold Agglutinins

Back 79

Found w/Mycoplasma pneumoniae

Front 80

Goljan Path

Panlobular Emphysema

Back 80

alpha1 - antitrypsin deficiency, causing elastase increased = increased compliance in the lung

Front 81

Goljan Path

Bulla

Back 81

Associated w/Emphhysema = "Bleb" = outpouching /
If it ruptures causes Pneumothorax

Front 82

Goljan Path

Farmer's Lung

Back 82

Due to Micropolyspora faeni (thermophilic actinomycetes)

Front 83

Goljan Path

Bagassosis

Back 83

Due to M. Vulgaris (actinomycetes)

Inhalation of sugar cane dust

Front 84

Goljan Path

Silo-Filler's Lung

Back 84

Due to Nitrogen dioxide from nitrates in corn

Front 85

Goljan Path

G6PDH Deficiency

Back 85

Sex-linked chronic hemolytic anemia w/o challenge of after eating fava beans

Heinz Bodies appear in RBCs

Front 86

Goljan Path

HbF greatly increased

Back 86

Sickle Cell Anemia

Front 87

Goljan Path

Multiple Myeloma

Back 87

Lytic lesions of flat bones ("salt & pepper lesions") = vertebrae, ribs, skull;

Hypercalcemia;
Bence-Jones protein casts

Front 88

Goljan Path

Hodgkin's Disease

Back 88

Malignant neoplasm of the lymph nodes causing pruritis;
fever = looks like an acute infection

Reed Stern berg cells

Front 89

Goljan Path

Polyarteritis Nodosa

Back 89

Immune complex disease of Ag-Ab complexes on blood vessel wall

Half of the immune complexes have Hepatitis B Ag

Can see fever; abd.pain: increased wt; HTN; muscle aches

Front 90

Goljan Path

Sprue

Back 90

Celiac disease due to a gluten-induced enteropathy = small intestine villi are blunted

High titers of anti-gliadin Abs & increased IgA levels

Front 91

Goljan Path

Regional Enteritis

Back 91

Crohn's Disease

Association w/Arthritus
Uveitis
Erythema Nodosum

Front 92

Goljan Path

Whipple's Disease

Back 92

Intestinal Lipodystrophy = malabsorption syndrome

Front 93

Goljan Path

Kulchitsky cells

Back 93

Neural cest cells from which carcinoids arise = of the Bronchi:

GIT:

Pancreas

Front 94

Goljan Path

Ulcerative Colitis

Back 94

Inflammatory disease of the colon w/increased colon CA incidence
Crypt abscess in the crypts of Lieberkuhn
Pseudopolyps when ulsers are deep
Not transmural involvement

Front 95

Goljan Path

Vaginal Adenosis

Back 95

Women exposed to DES (Diethylstilbesterol) in utero before the 18th week of pregnancy

Some develop clear cell adenocarcinoma of the vagina & cervix

Front 96

Goljan Path

Scirrhous Carcinoma

Back 96

Infiltration Duct Carcinoma w/ fibrosis - most common type of breast carcinoma

Front 97

Goljan Path

Hofbauer Cells

Back 97

Lipid laden macrophages seen in villi of Erythroblastosis Fetalis

Front 98

Goljan Path

Retinopathy of Prematurity

Back 98

Retrolintal Fibroplasia = cause of blindness in premies due to high O2 concentrations

Front 99

Goljan Path

IgA deficiency

Back 99

Pt has recurrent infections & diarrhea w/increased respiratory tract allergy & autoimmune diseases

If givend blood w/IgA = develop severe, fatal anaphylaxis reation

Front 100

Goljan Path

Primary Sjorgen's

Back 100

Dry eyes & dry mouth
arthritis
Increased risk for B cell lymphoma
HLA-DR3 frequent.
Autoimmune disease

Front 101

Goljan Path

Secondary Sjorgen's

Back 101

Rheumatoid arthritis, SLE or systemic sclerosis association

RA association shows HLA-DR4

Front 102

Goljan Path

LDH1 & LDH2

Back 102

Myocardium
LDH1 higher than LDH2 = Myocardial Infarction

Front 103

Goljan Path

LDH3

Back 103

Lung tissue

Front 104

Goljan Path

LDH4 & LDH5

Back 104

Liver cells

Front 105

Goljan Path

Keratomalacia

Back 105

Severe Vit A deficiency.

See Bitot's spots in the eyes = gray plaques = thickened, keratinized ET

Front 106

Goljan Path

Metabisfite Test

Back 106

Suspending RBCs in low O2 content solution

Can detect Hemoglobin S, which sickles in low O2

Front 107

Goljan Path

Microangiopathic Hemolytic Anemia

Back 107

Can be due to Hemolyitc Uremic Syndrome & Thrombotic Thrombocytopenic Purpura (TTP)

See Helmet cells

Front 108

Goljan Path

Wright's stain

Back 108

Stain for Burkitt's lymphoma

Front 109

Goljan Path

Mononucleosis

Back 109

Due to EBV infeciton

If Mono is treated w/Ampicillin, thinking that it is a strep pharyngitis, a rash will occur

Front 110

Goljan Path

T(8;14)

Back 110

Burkitt's lymphoma = c-myc oncogene overexpression

Front 111

Goljan Path

T(9;22)

Back 111

CML = c-abl/bcr gene formation = Philadelphia translocation

Front 112

Goljan Path

Langerhan Cell Histiocytosis

Back 112

Letter Siwe syndrome; Hand Schuller Christian Disease; Eosinophilic Granuloma

Birbeck granules are present = tennis racket shape

Front 113

Goljan Path

Myeloid Metaplasia

Back 113

Alkaline phosphatase increased/normal compare to CML = low to absent

Anemia; splenomegaly; platelets increased 1 million = extensive extra-medullary hematopoisis

Front 114

Goljan Path

Multiple Myeloma

Back 114

Weakness; wt. loss; recurrent infection; proteinuria; anemia; increased proliferation of plasma cells in BM=plasma cell dx
Serum M protein spike - most often of IgG or IgA

Hypercalcemia (increased bone destruction)

Front 115

Goljan Path

T(14;18)

Back 115

NH Lymphoma = bcl2 proto-oncogene overexpression seen w/ Small Cleaved Cell (Follicualr) Lymphoma

Front 116

Goljan Path

Focal Segmental GN exs

Back 116

IgA Focal GN = Berger's disease

SLE

PAN

Schonlien-Henoch purpura (anaphylactoid purpura)

Front 117

Goljan Path

Nephrotic syndrome exs

Back 117

Focal (Segmental) GN
Membranous GN
Lipoid (Minimal Change) GN
Membranoproliferative GN
Hep B
Syphilis
Penicillamine

Front 118

Goljan Path

Schistosoma Haematobium

Back 118

Infection is associated w/Squamous cell CA of the Bladder (most common Bladder CA is transitional cell type)

Associated w/portal HTN due to intrahepatic obstruction

Front 119

Goljan Path

Penicillin Resistant PID

Back 119

PID is usually due to N.Gonorrhoeae, but if unresponsive to penicillin think of Bacteroides species

Front 120

Goljan Path

Duret Hemorrhages

Back 120

Severe increase in ICP w/ downward diplacement of cerebellar tonsils into Foramen Magnum causing a compression on the brainstem w/hemorrhaging into the pons & midbrain

Nearly always associated w/death due to damage to the vital centers of these areas

Front 121

Goljan Path

Hypertensive Hemorrhage

Back 121

Predilection for lenticulostriate arteries = putamen & internal capsule hemorrhages

Front 122

Goljan Path

Cerebral Emboli are from

Back 122

MI w/Mural Thrombi
Atrial Fib Thrombi = Marantic thrombi
L-sided Bacterial Endocarditis;
Paradoxical Embolism of septal defect

Front 123

Goljan Path

Neurosyphilis

Back 123

Tabes Dorsalis = increase joint position sensation, increase pain sensation, ataxia, Argyl Robertson pupils

Syphilitic meningitis

Paretic neurosyphilis

Front 124

Goljan Path

5p-

Back 124

Cri di Chat: mental retardation
small head
wide set eyes
low set ears
cat-like cry

Front 125

Goljan Path

Trisomy 13

Back 125

Patau's small head & eyes

cleft lip & palate

many fingers

Front 126

Goljan Path

Acute Cold Agglutinaiton

Back 126

Abs to I blood group Ag. Mediated by IgM Abs

Complication of EBV or Mycoplasma pneumoniae infections

Front 127

Goljan Path

Chronic Cold Agglutinaiton

Back 127

Associated w/lymphoid neoplasms,

See agglutination & hemolysis in tussue exposed to cold

IgM Abs

Front 128

Goljan Path

RBC Osmotic Fragility

Back 128

Hereditary Spherocytosis

Front 129

Goljan Path

Non-Hodgkin's Lymphomas

Back 129

Small Lymphocytic: low grade B cell lymphoma of the elderly. Related to CLL
Small Cleaved cell (Follicualr); low grade B cell lymphoma of the elderly. T(14;18) bcl-2 oncogene
Large cell
Lymphoblastic: high grade T cell lymphoma of kids progressing to T-ALL
Small Non Cleaved = Burkitt's: high grade B cell lymphoma. EBV infection. Starry sky histo appearance.
T(8:14) c-myc proto-oncogene. Retlated to B-ALL

Front 130

Goljan Path

Singer's Nodules

Back 130

Benign laryngeal polyps associated w/smoking & oversue of the voice

Front 131

Goljan Path

Paraseptal emphysema

Back 131

Associated w/blebs (large subpleural bullae) that can rupture & casue pneumothorax

Front 132

Goljan Path

Superior Vena cava Syndrome

Back 132

Obstructed due to bronchogenic carcinoma.

Causing swollen face & cyanosis

Front 133

Goljan Path

Betal nuts

Back 133

Associated to oral cancer

Front 134

Goljan Path

Fundal (Type A) Gastritis

Back 134

Antibodies to parietal cells

pernicious anemia

autoimmune disease

Front 135

Goljan Path

Antral (Type B) Gastritis

Back 135

Associated w/Helicobacter (Campylobacter) pylori infection.

90% of duodenal ulcer

Front 136

Goljan Path

Primary Biliary Cirrhosis

Back 136

Autoimmune origin; middle aged women; anti-mitochondrial Abs

Jaundice; itching; hypercholesterolemia (can see cutaneous xanthomas)

Front 137

Goljan Path

Acute Pancreatitis

Back 137

Increased pancreatic enzymes = fat necrosis; sapponification = sypocalcemia; increased serum amylase

Severe epigastric ab pain; prostration; radiation to the back

Front 138

Goljan Path

Radiating Back Pain

Back 138

Chronic pancreatitis

Front 139

Goljan Path

Complete Hydatidiform Mole

Back 139

No embryo.

Paternal derivation only.

46XX

Front 140

Goljan Path

Partial Hydatidiform Mole

Back 140

Embryo

2 or more sperms fertilized 1 ovum

triploidy/tetraploidy occurs

Front 141

Goljan Path

Cold Nodules

Back 141

Hypoplastic Goiter nodules that do not take up radio active iodine. [Opposite; hot & do take up iodine]

Front 142

Goljan Path

Acidophils

Back 142

Mummotrophs = Prolactin

Somatotrophs = GH

Front 143

Goljan Path

Basophils

Back 143

Thyrotrophs = TSH

Gonadotrophs = LH

Corticotrophs = ACTH & FSH

Front 144

Goljan Path

Lacunar Strokes

Back 144

Small/focal aa occlusions. Purely motor or sensory.

Sensory: lesion of thalamus

Motor: lesion of internal capsule

Front 145

Goljan Path

CSF of Bacterial Meningitis

Back 145

Decreased Glucose

Increased Protein

Increased Neutrophils

Increased Pressure

Front 146

Goljan Path

CSF of Viral Meningitis

Back 146

Normal Glucose;

+/- increased Protein

Increased Lymphocytes

Front 147

Goljan Path

Marble Bone Disease

Back 147

Osteoporosis

Albers-Schonberd Disease = inspite of increased bone density,

many fractures = decreased osteoclasts

Front 148

Goljan Path

C5a

Back 148

Involved in Chemotaxis (for Neutrophils)

Front 149

Goljan Path

C3b

Back 149

Involved in Opsonization (& IgG)

Front 150

Goljan Path

Anaphylotoxis

Back 150

C3a & C5a (mediate Histamine release from Basophils & Mast cells)

Front 151

Goljan Path

vasoactive Mediators

Back 151

Vasoconstriction: TxA,; LTC4; LTD4; LTE4; PAF

Vasodilation: PGI2; PGD2; PGE2; PGF2alpha; Bradykinin; PAF

Increased Vascular Permeability: Hist.; 5HT; PGD2; PGE2; PGF2alpha; LTC4; LTD4; LTE4; Bradykinin; PAF

Front 152

Goljan Path

Platelet Aggregation

Back 152

ADP;

Thrombin;

TxA2;

collagen;

Epinephrine;

PAF

Front 153

Goljan Path

Platelet Antagonist

Back 153

Prostacyclin (PGI2)

Front 154

Goljan Path

Intrinsic Pathway

Back 154

F XII (Hagman): APTT

Front 155

Goljan Path

Extrinsic Pathway

Back 155

F VII: PT

Front 156

Goljan Path

Lines of Zahn

Back 156

Aterial thrombi = pale red colored (dark red is venous thrombi)

Front 157

Goljan Path

Currant Jelly appearance

Back 157

Post mortem clots

Front 158

Goljan Path

Emigration: Chemotaxis

Back 158

1. Margination
2. Pavementing
3. Adhesion
4. Chemotaxis
5. Phagocytosis
6. Intracellular microbial killing

Front 159

Goljan Path

Transulate

Back 159

Specific gravity < 1.012 - low protein

Front 160

Goljan Path

Exudate

Back 160

Specific gravity > 1.020 - high protein

Front 161

Goljan Path

Hurler's

Back 161

Lysosomal storage disease alpha L Iduronidase - Heparan/Dermatan Sulfate accumulation

Front 162

Goljan Path

Galactosemia

Back 162

Deficiency of Galactose 1 Phosphate Uridyl Transferace.

Increase Galactose 1 Phosphate

Front 163

Goljan Path

Phenylketonuria

Back 163

Deficiency: Phenylalanine Hydroxylase. Increase Phenyalanine & degradation products

Mousy body odor

Front 164

Goljan Path

Autosomal Dominant Diseases

Back 164

Adult Poly Cystic Kidney Disease
Familial Hypercholestrolemia Disease
Hereditary Hemorrhagic Telengectasia (Osler-Weber-Rendu)
Hereditary Spherocytosis
Huntington's Disease (chromosome 4p)
Marfam's Syndrome
Neurofibromatosis (von Recklinghausen's)
Tuberous Sclerosis
Von Hippel Lindau Disease

Front 165

Goljan Path

Autosomal Recessive Diseases

Back 165

Tay-Sachs
Gaucher's
Niemann-Pick
Hurler's
Von Gierke's

Front 166

Goljan Path

Autosomal Recessive Diseases

Back 166

Tay-Sachs
Gaucher's
Niemann=Pick
Hurler's
Von Gierke's
Pompe's
Cori's
McArdle's
Galactosemia
PKU
Alcaptonuria