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28 Cards in this Set
- Front
- Back
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most common blood group?
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O
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antibodies blood group O has?
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anti A IgM
anti B IgM anti AB IgG |
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antibodies blood group A has?
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anti B IgM
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antibodies blood group B has?
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anti A IgM
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antibodies blood group AB has?
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none
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an 84 year old male with type B blood is given a type A transfusion. what do you predict will happen?
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may NOT have hemolytic rxn. elderly frequently lose natural antibodies
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what is forward typing?
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process that identifies blood group antigens (ABO) using anti (X) serum testing
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blood testing: back typing
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identification of natural antibodies
pt serum added to test tubs w different types of RBCs (ABO) |
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what Rh antigen makes one Rh positive?
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D antigen
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what % of population is Rh positive?
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85%
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alloimmunization
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antibodies developed vs foreign antigens
ex: ab vs Rh in a Rh negative individual the antibody is termed "atypical" |
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what does Fy antigen (Duffy) negative RBCs protect against
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plasmodium vivax malaria
Fy antigens are binding sites |
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what is the most common pathogen transmitted by transfusion
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CMV (present in donor lymphocytes)
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what is the emergent treatment for warfarin anticoagulation?
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fresh frozen plasma
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plasma storage time
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5 days in autologous plasma
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how much will one unit of platelets rise the total count by?
THIS WILL BE TESTED |
goljan: 5-10k
syllabus: 8-10k |
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indications for fresh frozen plasma use
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treatment for multiple coag deficiencies
(DIC, cirrhosis, warfarin over-anticoagulation) most commonly used for congenital def |
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Cryoprecipitate
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treat coagulation factor def involving fibrinogen and factor VIII
(Hypofibrinogenemia) |
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universal donor and universal rec.
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blood group O(NEG): universal donor
AB(POS): universal rec |
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urticaria, hypotension, bronchospasm (wheezing) or anaphylaxis following a transfusion
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Allergic transfusion Reaction
Type I hypersensitivity (IgE) IgA deficiency = severe rxn tx mild cases w antihistamines |
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fever, chills, headache occuring 30min-2hrs following a transfusion
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Febrile Transfusion Rxn
Anti HLA Abs vs donor leukocytes (RBCs do not have HLA) |
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fever, chills hypotension, back pain eventually leading to DIC (following a transfusion) what happened?
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ABO blood group incompatability
intravascular hemolysis type II hypersensitivity (anti blood group IgM) |
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steps to reating a hemolytic transfusion
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d/c transfusion IMMEDIATELY
examine plasma for Hb maintain urine flow (fluids, diuretics) |
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1 week following a transfusion, unconjugated bili elevates, hemoglobin drops. whats going on?
what test should be considered? |
delayed hemolytic transfusion
(previous sensitization to red cell antigen) indirect coombs test will reveal patient antibody |
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what incompatability is the most common hemolytic disease of the newborn?
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ABO incompat.
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jaundice w/in 24hrs of birth, mild hemolytic anemia, and positive direct coombs test
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ABO hemolytic dz of newborn
(mothers Ig on fetal RBC) |
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what are the circumstances for Rh hemolytic dz of newborn?
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mother has to be Rh- but with prior exposure to Rh+ blood.
fetus must be Rh+ |
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what is used to prevent Rh dz of the newborn?
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RhoGam: Rh immune globulin - anti-D (anti-Rh)
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