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9 Cards in this Set
- Front
- Back
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GTN presentation
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600 mcg sublingual tablet
50 mg transdermal patch (0.4mg per hour) |
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GTN pharm
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vascular smooth muscle relaxant
venous dilation promotes venous pooling and reduces venous return to the heart (decreases preload) arterial dilation decreases SVR and arterial pressure (decreases afterload) reduces myocardial O2 demand reduces S/DBP and MAP whilst maintaining coronary perfusion pressure mild collateral coronary arterial dilation may improve blood supply to ischaemic areas of myocardium mild tachycardia secondary to slight fall in BP preterm labour: uterine quiescence in pregnancy |
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GTN metabolism
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by the liver
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GTN PI (5)
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1. chest pain with ACS
2. Acute LVF 3. Hypertension ass with ACS 4. Autonomic dysreflexia 5. Preterm labour (consult) |
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GTN CI (9)
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1. known hypersensitivity
2. SBP <110 mmHg (tablet) 3. SBP <90 mmHg (patch) 4. Sildenafil, Vardenafil in pre 24 hrs or Tardalafil in pre 4 days (PED5 inhibitors) 5. Heart rate >150 bpm 6. Heart rate <50 bpm (excluding AD) 7. VT 8. Inferior STEMI with SBP <160 mmHg 9. Right ventricular MI |
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GTN precautions (4)
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1. no previous admin
2. elderly pts 3. recent MI 4. concurrent use with other tocolytics |
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GTN routes
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SL
TD buccal infusion (interhosp only) |
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GTN SE
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tachycardia
hypotension headache skin flushing bradycardia |
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GTN SN
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check storage
original packaging tightly sealed sealed from heat and moisture discard after 1 month |
