Glycerophospholipid Metabolism

Front 1

glycerophospholipids consist of?

Back 1

A glycerol back bone, two fatty acid chains, and a phosphate head group that is variable and denotes the name.

Front 2

Phosphatidic Acid

Back 2

gycerophospholipid w/ no head group

Front 3

Phosphatidylcholine

Back 3

AKA Lethicin
need for surfactant production
If lacking RDS-- as in premature infant
Deficiency also results in dermatitis in TPN patients

Front 4

Phosphatidylinositol

Back 4

cleaved to form IP3 & DAG
Important in signal transduction
MOA of lithium
Arachadonic acid

Front 5

Degradation of Glycerophospholipids:
Phospholipase A2

What does it cut and why( what is the product) ?

Back 5

Phosphatidylinositol, to release arachadonic acid which is the precursor for prostaglandins

Front 6

Degradation of Glycerophospholipids:
Phospholipase A2
Where and when does it cut?
What is it inhibited by

Back 6

It is present in pancreatic secretions and snake and bee venom.
It requires trypsin and bile salts for activation.
It is inhibited by glucocorticoids (cortisol)

Front 7

Degradation of Glycerophospholipids:
Phospholipase C

What does it cut and why( what is the product) ?

Back 7

Phosphatidylinositol. It is activated by PIP2 system to release second messangers--IP3 & DAG.

Front 8

Degradation of Glycerophospholipids:
Phospholipase C
Where and when does it cut?

Back 8

Found in liver lysosomes and alpha toxins of bacteria.

Front 9

Describe steps of degredation of Phoshatidylinositol by Phospholipase C

Back 9

Hormone meets receptor. Receptor interacts with G protein. G protein activates Phospholipase C. Phospholipase C cleaves Phoshatidylinositol to IP3 & DAG. IP3 activates Ca++ channel which activates protein kinases. Kinases activate phosphorilations which mediate cellular response.

Front 10

MOA of Lithium

Back 10

IP3 needs to be recycled. This pathway is blocked by Lithium