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10 Cards in this Set

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glycerophospholipids consist of?
A glycerol back bone, two fatty acid chains, and a phosphate head group that is variable and denotes the name.
Phosphatidic Acid
gycerophospholipid w/ no head group
Phosphatidylcholine
AKA Lethicin
need for surfactant production
If lacking RDS-- as in premature infant
Deficiency also results in dermatitis in TPN patients
Phosphatidylinositol
cleaved to form IP3 & DAG
Important in signal transduction
MOA of lithium
Arachadonic acid
Degradation of Glycerophospholipids:
Phospholipase A2

What does it cut and why( what is the product) ?
Phosphatidylinositol, to release arachadonic acid which is the precursor for prostaglandins
Degradation of Glycerophospholipids:
Phospholipase A2
Where and when does it cut?
What is it inhibited by
It is present in pancreatic secretions and snake and bee venom.
It requires trypsin and bile salts for activation.
It is inhibited by glucocorticoids (cortisol)
Degradation of Glycerophospholipids:
Phospholipase C

What does it cut and why( what is the product) ?
Phosphatidylinositol. It is activated by PIP2 system to release second messangers--IP3 & DAG.
Degradation of Glycerophospholipids:
Phospholipase C
Where and when does it cut?
Found in liver lysosomes and alpha toxins of bacteria.
Describe steps of degredation of Phoshatidylinositol by Phospholipase C
Hormone meets receptor. Receptor interacts with G protein. G protein activates Phospholipase C. Phospholipase C cleaves Phoshatidylinositol to IP3 & DAG. IP3 activates Ca++ channel which activates protein kinases. Kinases activate phosphorilations which mediate cellular response.
MOA of Lithium
IP3 needs to be recycled. This pathway is blocked by Lithium