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13 Cards in this Set
- Front
- Back
- 3rd side (hint)
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Hydrocortisone (cortisol)
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Drug of choice in replacement therapy. t1\2- 8-12h. |
Relative potency in clinic use:
Anti-Inf- 1 Na+ retaining- 1 |
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Cortisone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. cheap, activation by conversion to cortisol, not used as an anti-inflammatory due to mineralocor' effect. t1\2- 8-12h. |
Relative potency in clinic use:
Anti-Inf- 0.8 Na+ retaining- 0.8 |
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Corticosterone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. t1\2- 8-12h. |
Relative potency in clinic use:
Anti-Inf- 0.3 Na+ retaining- 15 |
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Prednisolone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Drug of choice for systemic anti-inflam & immunosuppres effects. t1\2- 12-36h. |
Relative potency in clinic use:
Anti-Inf- 4 Na+ retaining- 0.8 |
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Prednisone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. activated by conversion to Prednisolone. largely used for systemic anti-inflam & immunosupres effects. t1\2- 12-36h. |
Relative potency in clinic use:
Anti-Inf- 4 Na+ retaining- 0.8 |
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Methylprednisolone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Anti inflam & immunosuppres. t1\2- 12-36h. |
Relative potency in clinic use:
Anti-Inf- 5 Na+ retaining- minimal |
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Triamcinolone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Relatively more toxic then others. t1\2- 12-36h. |
Relative potency in clinic use:
Anti-Inf- 5 Na+ retaining- none |
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Dexamethasone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Anti-inflm & immunosuppres, used especially where water retention is a problem (cerebral), drug of choice for suppres of ACTH production. t1\2- 36-72h. |
Relative potency in clinic use:
Anti-Inf- 30 Na+ retaining- minimal |
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Betamethasone
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Anti-inflm & immunosuppres, used especially where water retention is a problem (cerebral). t1\2- 36-72h. |
Relative potency in clinic use:
Anti-Inf- 30 Na+ retaining- negligible |
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Beclometasone dipropionate
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Use- Adrenal fail, anti-inflammatory, immunosuppresive therapy (auto-immune dis, transplant rejection), neoplasia (treat malignancies, reduce edema, anti-emetic).
SidEf- hyperglycemia, redistribution of fat, protein catabolism, decrease response to infection, osteoporosis, Cushing's syn. Anti-inflam & immunosuppres, effective topically & aerosol. |
Relative potency in clinic use:
Anti-Inf- (+) Na+ retaining- (-) |
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Deoxycortone
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mineralocorticoid
Uses- replacement therapy, addison's disease. SidEf- edema, HyperTens, muscle weakness (hypo K+). |
Relative potency in clinic use:
Anti-Inf- negligible Na+ retaining- 50 |
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Fludrocortisone
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mineralocorticoid
Uses- replacement therapy, addison's disease. SidEf- edema, HyperTens, muscle weakness (hypo K+). drug of choice for mineralocorticoid effect. t1\2- 8-12h |
Relative potency in clinic use:
Anti-Inf- 15 Na+ retaining- 150 |
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Aldosterone
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mineralocorticoid
Uses- replacement therapy, addison's disease. SidEf- edema, HyperTens, muscle weakness (hypo K+). endogenous mineralocorticoid. |
Relative potency in clinic use:
Anti-Inf- none Na+ retaining- 500 |
