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19 Cards in this Set
- Front
- Back
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Does chemotherapy cross the placenta?
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Yes
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What are fetal risks for chemotherapy in pregnancy if given after the first trimester?
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still birth
intra-uterine growth restriction fetal toxicities |
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what are the most common cancers for women aged 20-44?
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Breast cancer - 34%
Cervical Cancer - 10% Thyroid cancer- 9% |
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what is the percentage of cancer in pregnancy?
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0.02% - 0.1%
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what is the definition of teratogenicity
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the structural or functional dysgenesis of fetal organs
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what is the baseline rate of congenital malformations?
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1-3%
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what the molecular weight through which molecules can pass through the placenta?
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500 daltons
if >1000 daltons- then cannot pass |
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what is the all -or-none period?
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from conception to 8-14 days
an insult at this time leads to miscarriage or intact survival |
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what is the most sensitive time for drug exposure?
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2-8 weeks post-conceptin
esp. week 3-5 |
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what impact can drugs have during the fetal phase?
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Can lead to IUGR, low birth weight
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What is the type of malformations that thalidomide use lead to?
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Phocomelia - under-developed limbs and absent pelvic bones
CNS abnormality |
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what is thalidomide and lenalidomide currently used for?
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the treatment of multiple myeloma
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Most fetuses with exposure to chemotherapy in the second trimester are born___________
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healthy
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what do the platinum chemotherapeutic agents do?
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impairs DNA cross-linking
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what do the taxanes and plant alkaloids do?
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inhibit mitosis
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In general chemotherapeutic agents in the 2nd trimester do not lead to specific harm? T or F
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True
there were abnormalities, but not a specific collection |
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When should you usually deliver women who have been on chemo?
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usually want to wait 2-3 weeks until the myelosuppression improves
and fetal drug excretion from the placenta has occurred |
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should you breast feed while on chemo?
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NO
except with azathioprine |
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what is another concern for women who get chemo while pregnant?
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there is an increased risk for secondary malignancy in the children born to the mothers who got chemo
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