Gi: Zieg

Front 1

Name 3 bugs with preformed toxins

Back 1

Bacillus cereus (emetic disease), Clostridia botulinum, Staph aureus

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Virulence factor of bacillus cereus (emetic)

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HS enterotoxin

Front 3

Tx of Bacillus cereus (emetic)

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Supportive

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VF of Clostridia botulinum

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HL neurotoxin

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Tx of Clostridia botulinum

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Trivalent antitoxin

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VF of staph aureus

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HS enterotoxins

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VFs of Bacillus cereus (diarrheal) and Clostridia Perfringens

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HL enterotoxin

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Tx of bacillus cereus (diarrheal) disease

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Vanco

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Tx of Clostridia Perfringens

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Pen G

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Tx for ETEC and EHEC

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Supportive

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VFs of ETEC

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Pili, LT and ST enterotoxins, pathogenicity plasmid

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VFs of EHEC

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HS Verotoxin, pathogenicity plasmid

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Tx of Vibrio cholera

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Tetracylcine or Doxycycline

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VF of Vibrio parahaeomolyticus

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HS enterotoxins

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Tx of Vibrio parahaemolyticus

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Tetracycline

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VFs of Campylobacter

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Enterotoxin, flagella, adhesins, endotoxin

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Tx of Campylobacter

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Erythromycin; Ciprofloxacin

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EIEC VFs

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Type III secretion system, pathogenicity plasmid

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Tx of EIEC

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Supportive

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VFs of Listeria monocytogenes

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Listerolysin, Act A (surface protein) Internalin

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Tx of Listeria monocytogenes

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Ampicillin or Pen G

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VFs of Salmonella

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Fimbria, Invasion antigens, Type III secretion system, Pathogenicity plasmid, Type III cytotoxins

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Tx of Salmonella

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supportive

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VFs of Shigella

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Shigatoxin, Invasion antigens, Type III secretion system, pathogenicity plasmid

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Tx of Shigella

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Sulfamethoxazole or Ciprofloxacin

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VFs of Yersinia enterocolitica

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Type III cytotoxins, Yops proteins, HS enterotoxin

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Tx of Yersinia enterocolitica

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supportive

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Tx of Norovirus

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Supportive

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Difference between Shigella and Salmonella

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Salmonella makes Hydrogen sulfide

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Bugs assoc with pathogenicity plasmid

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ETEC, EHEC, EIEC, Salmonella, Shigella

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Bugs assoc with Type III secretion system

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Shigella, EIEC, Salmonella

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Bugs assoc with pathogenicity plasmid

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ETEC, EHEC, EIEC, Salmonella, Shigella

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Bugs assoc with Type III secretion system

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Shigella, EIEC, Salmonella

Front 34

MOA and effect of HS peptide, cytotoxin of Bacillus cereus (emetic)

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Membrane damage --> diarrhea

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MOA and effect of Bacillus cereus diarrheal protein toxin

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Pore formation and activate adenylate cyclase --> diarrhea

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MOA and effect of HL enterotoxin of Clostridia perfringens

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Pore formation, membrane damage --> diarrhea

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MOA and effect of HL enterotoxin AB 5 of E coli

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Activates adenylate cylcase

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MOA and effect of Cytotoxin of E coli

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Like Shiga toxin (inactivates 60S) --> hemorrhagic colitis

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MOA and effect of HS enterotoxin of E coli

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Activates host guanylate cyclase --> diarrhea

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MOA and effect of Listeriolysin of Listeria monocytogenes

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Lyses phagosome --> intracellular survival

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MOA and effect of Type III cytotoxins of Salmonella and Yersinia enterocolitica

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Alter actin cytoskeleton --> Diarrhea

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MOA and effect of Shiga Toxin of Shigella dysenteriae

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Inactivates 60S --> Kills cells

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MOA and effect of enterotoxins of Staph auerus

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Superantigens --> diarrhea

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MOA and effect of HS enterotoxin of Yersinia enterocolitical

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Activates host guanylate cyclase --> diarrhea