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35 Cards in this Set
- Front
- Back
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Compare location of UC v. Crohn's
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UC is colon only, any GI segment
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Compare smoking use of UC v. Crohn's
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UC is non-smoker; Crohn's is smoker
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Compare spread of UC v. Crohn's
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UC is diffuse v. Crohn's is focal, asymmetric
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Compare layer affected of UC v. Crohn's
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UC is mucosal, Crohn's is transmural
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Age of onset of IBD
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15-30yo
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Which IBD more affects females?
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Crohn's
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When are 2 peaks of IBD?
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20y and 50y
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Which IBD demonstrates an North-South gradient?
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Crohn's, not as much UC
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General lymphocyte responsible for IBD? CD? UC?
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T-cells
CD-Th1, Th17 UC-Th2, NK |
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2 most abundant colon bacteria
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Gram- Bacteroidetes
Gram+ Fermicutes |
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What balance helps with early childhood infection?
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Th1 and Treg cells
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Genetics of IBD
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complex, non-Mendelian disorder
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NOD2 indicated in what?
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Crohn's disease (up to 40%)
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Extra-intestinal manifestations of Crohn's dz
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skin, liver, eyes, joints
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DDx for Crohn's dz
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neoplasms
vascular dz infections RLQ inflammatory dz (appendicitis, endometriosis) |
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percentage of Crohn's dz at ileum
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70%
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Eval of Crohn's dz
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stool studies (pathogens)
Blood studies for CBC, crp, albumin Small bowel imaging endoscopy |
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Clinical presentation of Crohn's dz
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abdominal pain, diarrhea, weight loss, fever, perianal dz
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Endoscopic appearance of Crohn's disease
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ulcers w/ normal tissue interspersed
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Which IBD has skip lesions?
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Crohn's dz
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Clinical features of inflammation on Crohn's
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pain, tenderness, diarrhea
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Clinical features of obstruction on Crohn's
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Cramps, distention, vomiting
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Underlying path of perianal dz in Crohn's dz
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fistulas to surface
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2 key deficiencies in Crohn's dz
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bile salt diarrhea, B12 deficiency
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DDx of Ulcerative Colitis
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Crohn's colitis
ischemic colitis infections antibiotic effects NSAIDs diversion/diverticular colitis |
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Clinical presentation of UC
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bloody diarrhea
tenesmus crampy ab pain w/ bowel movements weight loss fever growth retardation in children |
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UC on endoscopy
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diffuse damage, lack of focal ulcers
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Toxic megacolon in UC presentation
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>10 stools/d
severe cramps fever to 39.5 need for blood transfusion rapid weight loss |
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What is inc in UC pts?
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colorectal cancer
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J pouch for UC pts, key change for bowel movements?
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small intestine attached to anus, 7-12 BMs/day
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Skin disorders in IBD
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erythema nodosum (parallels gut dz)
pyoderma gangrenosum cutaneous Crohn's dz |
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musculoskeletal disorders in IBD
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peripheral arthritis (parallels gut dz)
sacroileitis ankylosing spondylitis |
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Ocular changes in IBD
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uveitis
scleritis/episcleritis |
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Hepatobiliary disorders in IBD
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PSC
pericholangitis cholangiocarcinoma gallstones |
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Other extra-intestinal manifestations in IBD
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aphthous stomatitis (mouth sores)
Tx: lidocaine, beclomethasone, antibiotics, dapsone DVT/PE |
