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22 Cards in this Set
- Front
- Back
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Cause of Whipple's disease
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tropheryma whipplei, gram+ actinomycete
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Target population of Whipple's disease
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commonly males, middle aged (40-50s), white
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Histo of Whipple's disease
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flattening and widening of villi, strongly PAS+, clear spaces (lipid droplets)
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CMV damage due to...
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infection of endothelium
ischemic necrosis of mucosa & ulceration |
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Micro findings with CMV
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cytomegaly
eosinophilic intranuclear inclusion bodies, cytoplasmic inclusions endothelial cells/fibroblasts affected |
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Type of tissue most affected by HSV
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squamous epithelium (esophagus/anal canal)
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Where do each herpes simplex types occur?
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esophagus-type I
anal region-type II |
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Herpes viral effect on cells
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multinucleated squamous epithelial cells
ground glass nucleoplasm margination of normal chromatin forming a peripheral rim |
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Histopath of cryptosporidium parvum
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PAS+, in microvilli border, can have villous atrophy w/ intense neutrophilic infiltration
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Where is parasite in cryptosporidium?
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Beneath cell membrane, not in cytoplasm
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Giardia target population
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water-borne illness, hunters, child day care, MSM
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Histopath of giardia
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forms physical barrier to absorption by adherence of trophozoites to mucosal surface
-pear shaped organisms, damage to MV brush border |
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Gross path of amebiasis
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friable, erythematous mucosa and ulceration (cecum)
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Microscopic findings of amebiasis
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flask-shaped ulcers into muscularis
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Amebae staining in colon biopsies?
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PAS stain
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2 main types of chronic colitis
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watery and bloody
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2 types of microscopic colitis
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lymphocytic and collagenous
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Which microscopic colitis type is more common in Celiac disease pts?
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lymphocytic colitis
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Where is collagenous colitis found?
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close to lumen (trichrome)
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Most severe locations of celiac dz
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distal duodenum, proximal jejunum
(minimal in distal ileum) |
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Histo findings in celiac dz
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villous blunting
inc lymphocytes and plasma cells in lamina propria inc lymph. in epithelium characteristic, but not specific |
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Changes in epithelium for celiac dz
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High columnar epithelium in normal
low cubocolumnar epithelium in celiac dz |
