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16 Cards in this Set

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Intrinsic Factor
Parietal Cells
Autoimmune destruction --> chronic gastritis and pernicious anemia
Gastric Acid
Parietal Cells
Stim by HAG: histamine, ACh, gastrin
Inhib by: GIP, prostaglandin, somatostatin
Is gastric acid essential for digestion?
No, but inadequate acid increases risk of salmonella infections.
Pepsin
Chief cells
Stim by vagal input, local acid
(Inactive pepsinogen ->pepsin by H+)
Gastrin
G cells of antrum
Stim: secretion of HCl, IF, pepsinogen; gastric motility
Gastrin
stim by: stomach distention, AA, peptides, vagus
Inhib by: secretin, low stomach acid (neg feedback)
Zollinger-Ellison sxme
hypersecretion of gastrin
peptic ulcers; Phe and Tryptophan are stimulators (Ass'd with MEN1)
Bicarb
surface mucosal cells of stomach and duodenum
1. neutrolizes acid 2. in mucus layer 3. prevents autodigestion
Stim by secretin (potentiated by vagus, CCK)
CCK
I cells of duodenum
CCK
Stim gall bladder contraction, panc enzyme secretion
Inhib gastric emptying
Stim by: FA, AA
Secretin
S cells of duodenum
(Nature's antacid) - stim panc bicarb and inhibits gastric acid secretion
Secretin
Stim by acid and FA in duodenum
Somatostatin
D cells in panc islets, GI mucosa
Somatostatin
Inhibits: gastric acid and pepsinogen secretion, panc and small intestine fluid secretion, gallbladder contraction, release of insulin and glucagon
**anti-GH effects d/t decreased digestion and absorption of substances needed for growth
Somatostatin
stim by acid
inhib by vagus
GIP
decrease H secretion and increase insulin release (reason for oral glucose loading vs IV)
K cells of duodenum and jejunum
only hormone stim by all 3: AA, FA, glucose