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29 Cards in this Set

  • Front
  • Back
source of gastrin
G cells in antrum of stomach
source of CCK
I cells in duo and jejunum
source of secretin
s cells, duodenum
action of gastrin
increased H+ in stomach
increased growth of gatric mucosa
increased gastric motility
action of CCK
increases pancreatic secretions
increases gallbladder contraction
slows gastric emptying
action of secretin
release of HCO3-
decreased gastric acid secretion
regulation of gastrin
decreased when stomach pH <1.5
increased when stomach is distended, presence of AA and peptides
increased in vagal stimulation
regulation of CCK
decreased if stomach pH<1.5
decreased by secretin
increased by fatty acids and AA
regulation of secretin
increased by acid, FA in lumen of duo
source of somatostatin
D cells of pancreatic islets and GI mucosa
what regulates somatostatin
increased by acid
decreased by vagal stimulation
what is somatostatin used to treat
VIPoma
carcinoid tumors
what releases GIP?
K cells in duo and jejunum
what does GIP do?
exocrine fxn of decreasing H secretion
endocrine fxn of increasing insulin release
regulation of GIP
increased by fatty acids, AA, oral glucose
which is used more rapidly: oral or IV glucose?
oral
source of VIP
parasympathetic ganglia in sphincters, gallbladder and small intestines
action of VIP
increases intestinal water absorption
relaxation of intestinal smooth muscle and sphincters
regulation of VIP
increased by distention and vagal stimulation
decreased by adrenergic imput
what is VIPoma
non-alpha, non-beta islet cell pancreatic tumor that secrete VIP --> copious watery diarrhea
action of NO on GI tract
increased smooth muscle relaxation, (NB: lower P in LES)
what is implicated in decreased NO secretion
accounts for incresed LES tone seen in achalasia
where is HCO3- released from?
mucosal cells
stomach
duo
where is pepsin released from?
chief cells of stomach
what controls gastric acid release
increased by histamine and ACh
decreased by somatostatin, GIP, PG, secretin
fxn of salivary amylase
hydrolyzes alpha-1,4 linkages --> disaccharides
fxn of pancreatic amylase
hydrolyzes starch to oligosaccharides and disaccharides
where is pancreatic amylase found
highest [] in duo lumen
fxn of oligosaccharide hydrolase
hydrolyzes oligosaccharidses --> monosaccharides
RL step in carb digestion