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41 Cards in this Set
- Front
- Back
|
cimetidine
mech |
histamine H2 R reversible blocker
less acid secretion (parietal cell) |
|
|
cimetidine
use |
peptic ulcer
gastritis gerd |
|
|
cimetidine
se |
inhibit p450
antiadrogenic (gynecomastia, impotence, alibido) cross BBB (confused, dizzy, HA) teratogenic decrease renal excretion of creatinine |
|
|
rantidine
mech |
reversible histamine H2 R blocker
stop acid from parietal cell |
|
|
rantidine
use |
gastric ulcer
gastritis gerd |
|
|
rantidine
se |
decrease renal excretion of creatinine
|
|
|
famotidine
mech |
h2 blocker
no acid from parietal cells |
|
|
famotidine
use |
gastric ulcer
gastritis gerd |
|
|
nizatidine
mech |
h2 blocker
no acid fr parietal cell |
|
|
nizatidine
use |
gastric ulcer
gastritis gerd |
|
|
omeprazole
mech |
proton pump inhibitor in parietal cell (h/k antiport)
|
|
|
omeprazole
use |
gastric ulcer
gastritis gerd zollinger ellison |
|
|
lansoprazole
mech |
ppi in parietal cell (h/k antiport)
|
|
|
lansoprazole
use |
gastric ulcer
gastritis gerd zolinger ellison |
|
|
bismuth
mech |
binds ulcer base to protect
acid buffer |
|
|
bismuth
use |
ulcer
traveler diarrhea |
|
|
sucralfate
mech |
bind ulcer base to protect
acid buffer |
|
|
sucralfate
use |
ulcer
traveler diarrhea |
|
|
treatment of h pylori ulcer
|
"Please MAke Tummy Better"
ppi metronidazole amoxicillin OR tetracylcine bismuth |
|
|
misoprostol
mech |
PGE1
more gastric mucus barrier decrease acid |
|
|
misoprostol
use |
nsaid-induced gastric ulcer prevention
maintain patent ductus arteriosus induce labor |
|
|
misoprostol
se |
diarrhea
abortifacient |
|
|
pirenzpine
mech |
muscrainic blocker
block M1 R on ECL cell no histamine block M3 R on parietal cell no acid |
|
|
pirenzipine
use |
peptic ulcer - rare
|
|
|
pirenzipine
se |
tachycarida
cant focus eyes |
|
|
propantheline
mech |
muscranic blocker
m1 R on ECL - no histamine m3 R on parietal - no acid |
|
|
propantheline
use |
rarely petpic ulcer
|
|
|
propanthelien
se |
tachycardia
cant focus eyes |
|
|
antacids
se |
affect excretion or absorption
1. AlOH - constipated, low P, m weak, osteodystrophy, seizures 2. MgOH - diarrhea, low reflex, low BP, cardiac arrest 3. CaCO3 - high Ca, rebound acid hypokalemia chelate and decrease drug effectivenss (tetracylcine) |
|
|
infliximab
mech |
monoclonal ab to TNF (proinflammation)
|
|
|
infliximab
use |
crohns
rheumatoid arthritis |
|
|
infliximab
se |
lung infxn (reactivate TB)
fever hypotension |
|
|
sulfasazine
mech |
sulfapyridine (antibacteria) and 5ASA (anti-inflammatory)
activated by colon flora |
|
|
sulfazine
use |
ulcerative colitis
crohns |
|
|
sulfazine
se |
nausea
reversible male infertility |
|
|
odansetron
mech |
5-HT3 antagonist
antiemetic |
|
|
odansetron
use |
postop vomiting
chemo pts |
|
|
odansetron
se |
Headache
constipated |
|
|
metoclopramide
mech |
D2 antagonist
increase rest tone (LES) contracts so motility no influence on colon transport time |
|
|
metoclopramide
use |
diabetic and post-op gastroparesis
|
|
|
metoclopramide
se |
PARKINSONIAN effects
digoxin and diabetic interaction contraindicated: small bowel obstruct |
