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21 Cards in this Set
- Front
- Back
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Name some H2 blockers:
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- cimetidine
- ranitidine - famotidine - nizatidine |
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What do H2 blockers do?
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decrease acid secretion by parietal cells of stomach
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Which cells release Histamine in response to Gastrin?
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enterochromaffin like cells
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When would you give an H2 blocker?
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- peptic ulcer disease
- gastritis - mild GERD |
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What are toxicities of cimetidine?
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- inhibit P450
- antiandrogenic - dec. renal excretion of Cr |
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What do Omeprazole & Lansoprazole do?
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Proton pump inhibitors - irreversibly block axn of H/K ATPase of parietal cells, which pumps H+ into stomach lumen
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When would you give a PPI?
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- Zollinger Ellison syndrome
- peptic ulcer disease - gastritis - GERD |
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How do Bismuth and sucralfate work?
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Bind to ulcer base as physical shield from gastric acid. Allow ulcer to heal.
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Bismuth is part of the triple therapy for H. pylori along with:
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- tetracycline or amoxicillin
- metronidazole |
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What is Misoprostol and what does it do?
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PGE-1 analog - increase stomach mucus barrier and decrease acid production
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What 3 situations would you use Misoprostol?
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- prevent NSAID-induced ulcer
- maintain PDA! - induce labor! |
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For whom would you NOT use misoprostol?
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Women of childbearing potential - abortion
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What is a good drug to give a patient postoperatively, or after chemo, to prevent vomiting?
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Ondansetron - 5HT3 antagonist
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Pirenzepine & Propantheline =
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Antimuscarinics for peptic ulcers - block M1 on ECL cells, M3 on parietal cells (dec. histamine release, dec. H+ release)
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What are toxicities of Pirenzepine & Propantheline?
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- tachycardia
- dry mouth - difficulty focusing eyes |
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What is Infliximab used for?
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Crohn's, rheumatoid arthritis - monoclonal Ab to TNFa
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Toxicities of Infliximab?
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- respiratory infection
- fever - hypotension |
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Sulfasalazine is a combo of:
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sulfapyridine (antibacterial) + mesalamine (anti-inflammatory)
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Sulfasalazine is used for:
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UC, Crohn's
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Toxicities of Sulfasalazine?
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- reversible oligospermia
- sulfa allergy - malaise - nausea |
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What happens if you overuse antacids?
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- aluminum hydroxide --> constipation, hypophosphatemia
- magnesium hydroxide --> diarrhea - calcium carbonate --> hypercalcemia, rebound acid rise - all antacids --> hypokalemia |
