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73 Cards in this Set
- Front
- Back
- 3rd side (hint)
esophagus
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Reflux Esophagitis
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may be asymptomatic, may have associated Barrett's
hyperplasia of basal cells, elongated papillae, intramucosal lymphocytes w/ or w/o eosinophils |
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Esophagus
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Barret Esophagus
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Reflux esophagitis w/ Goblet cells
Dysplasia identified by the presence of goblet cells, these pts placed on strict surveillance programs to monitor progression to adenocarcinoma Condition is reversible w/ treatment RE-->BE-->dysplasia-->cancer |
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stomach
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Gastritis (H. Pylori)
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HP plays a role in acute/chronic gastritis, gastric/duodenal ulcers, gastric adenocarcinoma, gastric lymphoma
Immunocompromised pts may have CMV, adeno, or herpes virus Reactive gastropathy secondary to bile reflux or meds (NSAIDs) |
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stomach
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Erosive Gastritis
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NSAIDs
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small bowel
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Celiac Disease
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increased CD8 T-lymphocytes, hyperplastic crypts, mitotic figures, short wide villi
1/200-300 affected Dx: clinical, endoscope, lab tx: gluten free diet associated dz: T-cell lymphomas, bowel/esophageal/oropharyngeal/breast carcinomas Tropical Sprue presents similarly in pts w/ travel Hx |
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small bowel
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Whipple Disease
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systemic bacterial infection of Tropheryma Whippelii (actinomyces)
Dx w/ PAS positive bacilli within small bowel macrophages |
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esophagus
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Eosinophilic Esophagus
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Simulates RE, biopsy includes 25 eos/high power field
idiopathic, allergic, hypereo syndrome, Rx, parasites, reflux may present w/ food bolus obstruction associated w/ allergic condition ribbed or feline esophagus on endoscopy Perforation risk Tx: steroids, dietary restriction, dilation |
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Eosinophilic Esophagitis
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Simulates RE, biopsy includes 25 eos/high power field
idiopathic, allergic, hypereo syndrome, Rx, parasites, reflux may present w/ food bolus obstruction associated w/ allergic condition ribbed or feline esophagus on endoscopy Perforation risk Tx: steroids, dietary restriction, dilation |
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Chronic Active Gastritis
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lymphocytes, lymphoid follicles, decreased # microorganisms
complications: metaplasia, adenocarcinoma, malignant lymphoma, ulcer, reflux, carditis |
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H. Pylori
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esophagus
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Barret's Esophagus
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complication of gastritis, cancer precursor
RE-->BE-->dysplasia-->adenocarcinoma |
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Intestinal metaplasia w/ high grade dysplasia
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note proximity of glands in upper L corner
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Celiac Disease
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increased CD8 T-lymphocytes, hyperplastic crypts, mitotic figures, short wide villi
1/200-300 affected Dx: clinical, endoscope, lab tx: gluten free diet associated dz: T-cell lymphomas, bowel/esophageal/oropharyngeal/breast carcinomas Tropical Sprue presents similarly in pts w/ travel Hx |
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Celiac Disease (Note intraepithelial lympocytes)
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increased CD8 T-lymphocytes, hyperplastic crypts, mitotic figures, short wide villi
1/200-300 affected Dx: clinical, endoscope, lab tx: gluten free diet associated dz: T-cell lymphomas, bowel/esophageal/oropharyngeal/breast carcinomas Tropical Sprue presents similarly in pts w/ travel Hx |
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Gastritis DDx
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H. Pylori --> gastric biopsy
Radiation --> Hx? Lymphoma: Abnormal cells, no improvement w/ diet Food Protein Intolerance: eos, asthma, responds to diet Tropical Sprue: Responds to Abx & folate Autoimmune enteropathy: young age, anti-enterocyte Ab |
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Hirschprung's Disease
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lack of gangion cells in rectosigmoid/anal region
1/5000, favors males infant presents w/ severe constipation, requires surgical management |
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Hirschprung Disease
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lack of gangion cells in rectosigmoid/anal region
1/5000, favors males infant presents w/ severe constipation, requires surgical management |
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Infectious colitis Bugs
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C. Diff - pseudomembranes, necrotic cells, neutrophils, and exudates
Yerisinia - necrosis in lymphoid aggregates around ileocecal valve Salmonella - ulcers overlying hyperplastic Peyer's patches |
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Ulcerative Colitis
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diffuse superficial involvement of the mucosa of the left colon, sigmoid, and rectum.
no granulomas increased risk of cancer shows crypt distortion & basal plasma cells |
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Ulcerative Colitis (note gland distortion)
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diffuse superficial involvement of the mucosa of the left colon, sigmoid, and rectum.
no granulomas increased risk of cancer shows crypt distortion & basal plasma cells |
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Ulcerative Colitis
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diffuse superficial involvement of the mucosa of the left colon, sigmoid, and rectum.
no granulomas increased risk of cancer shows crypt distortion & basal plasma cells |
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Colon
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Crohn's Disease
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Crohn's Disease affects the R colon, ileum, & upper GI. transmuarl inflammation w/ areas of normal mucosa, fissures, ulcers, non-necrotic, granulomas, & fistulas
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Inflammatory Bowel Disase
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Crohns: intestinal obstructions (fistulas), adenocarcinomas. 3NOD2 & CARD15 genetically predispose
Ulcerative Colitis: toxic megacolon, perforation, adenocarcinoma, arthritis, uveitis, pyoderma gangrenosum pts. must follow up for endoscopic exams and biopsies to screen for adenocarcinoma |
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IBD pseudopolyp
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IBD Dysplasia "picket fencing"
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Ischemic Colitis
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low flow states (sepsis, CHF, shock), thromboembolism, adhesions, strangulated hernia, vasculitis, estrogen compounds
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Ischemic Colitis
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low flow states (sepsis, CHF, shock), thromboembolism, adhesions, strangulated hernia, vasculitis, estrogen compounds
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Collagenous Colitis
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older population, predominantly female
normal endoscopic findings, long standing watery diarrhea intraepithelial lymphocytosis, mixed acute/chronic infiltrate, basement membrane diffusely thickened |
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Pseudomembranous colitis
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C. Diff infection
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colon
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GVHD
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graft versus host disease, note the apoptotic cells.
often following allogeneic bone marrow transplant |
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Lymphocytic Colitis (note intraepithelial lymphocytes)
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chronic watery diarrhea, middle aged, normal endoscopic findings, negative stool cultures
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ischemic colitis
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low flow states (sepsis, CHF, shock), thromboembolism, adhesions, strangulated hernia, vasculitis, estrogen compound
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ischemic colitis
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low flow states (sepsis, CHF, shock), thromboembolism, adhesions, strangulated hernia, vasculitis, estrogen compound
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Ulcerative Colitis
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diffuse superficial involvement of the mucosa of the left colon, sigmoid, and rectum.
no granulomas increased risk of cancer shows crypt distortion & basal plasma cell |
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Ulcerative Colitis (note dysplasia)
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diffuse superficial involvement of the mucosa of the left colon, sigmoid, and rectum.
no granulomas increased risk of cancer shows crypt distortion & basal plasma cell |
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Ulcerative Colitis
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diffuse superficial involvement of the mucosa of the left colon, sigmoid, and rectum.
no granulomas increased risk of cancer shows crypt distortion & basal plasma cell |
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Crohn Disease
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Crohn's Disease affects the R colon, ileum, & upper GI. transmuarl inflammation w/ areas of normal mucosa, fissures, ulcers, non-necrotic, granulomas, & fistulas
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Crohn Disease
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Crohn's Disease affects the R colon, ileum, & upper GI. transmuarl inflammation w/ areas of normal mucosa, fissures, ulcers, non-necrotic, granulomas, & fistulas
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Achalasia
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Acute Appendicitis
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Adenocarcinoma (from polyp)
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Adenocarcinoma
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Autoimmune Gastritis
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Colon Diverticulosis
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Duodenal Ulcer
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Esophageal Carcinoma
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Esophageal Varices
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Familial Polyposis
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Gastric Adenocarcinoma
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Gastric Ulcer
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Gastric Ulcer
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Hyperplastic Polyp
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Hyperplastic Polyp (Variants)
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Small Bowel Infarct
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Infiltrating Gastric Carcinoma
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Infiltrating Gastric Carcinoma
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Inflammatory Polyps
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Intussusception
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Juvenile Polyp
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MALT Lymphoma
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Meckel Diverticulum
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Mediterranean Intestinal Lymphoma
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Menetrier Disease
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Mucocele of the Appendix
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Small Intestine
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Neuroendocrine Tumor
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Peutz-Jegher
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Schatzki
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Stromal Tumor of the Stomach
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Trichobezoar
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Tubular Adenoma
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Trichobezoar
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Villous Adenoma
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Ulcerating Gastric Carcinoma
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