Reading...
Play button
Play button
Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
31 Cards in this Set
- Front
- Back
|
Gastrin
|
Gastrin-CCK Family; G cells (antrum)
increase gastric acid secretion, stimulates mucosa growth, stimulates ECL histamine release. Stimuli: 1. small peps/AAs 2. distention. 3. Vagus (via GRP) Inhibitions: 1. H+ in stomach 2. Somatostatin. |
|
|
CCK
|
Gastrin-CCK, I cells of Duodenum and Jejunum.
Stimulates GB contract, Oddi relax... 1.increase pancreatic enzyme AND HCO3- secretion 2.increase growth of exocrine pancreas/gallbladder. 3.inhibits gastric emptying. Stimuli: Small peps/AAs, and FATTY ACIDS. Inhib: NONE LISTED. |
|
|
Secretin
|
secretin-Glucagon; S cells of DUODENUM.
increases pancreatic HCO3- secretion, increase BILIARY HCO3-, DECREASE gastric H+. Stimuli: H+ in DUODENUM, FATTY ACIDS in DUOD. |
|
|
GIP
|
Secretin-Glucagon, in DUODENUM and JEJUNUM.
Increase INSULIN secretion, decrease GASRIC H secretion... stimulate: FA, AA, oral Glucose... |
|
|
vip
|
homologous to SECRETIN.
relaxtion of GI smooth muscle (and LES). stimulates panc. HCO3- sec. and inhibits gastric H+ sec. Secreted by pancreatic islet cell tumors, mediates panc. cholera. |
|
|
Pepsinogen secretion stimulated by:
|
Gastrin, CCK, Secretin.
|
|
|
Pancreatic Growth stimulated by
|
CCK, Secretin.
|
|
|
Gastric Mucosal Growth: stimuli and inhibition....
|
stim - gastrin
inhib - secretin. |
|
|
Gastric emptying stimuli and inhib...
|
Stim - gastrin
inhib - CCK, secretin. |
|
|
Pancreatic HCO3- secretion
|
CCK, secretin.
|
|
|
Biliary HCO3 secretion
|
secretin.
|
|
|
gastric acid secretion stim. and inhib...
|
stim - gastrin
inhib - secretin, GIP. |
|
|
Seratonin WRT GI contractions:
|
increases GI contractions.
|
|
|
VIP WRT GI contractions
|
decreases!!!
|
|
|
Glucagon WRT GI contractions
|
decreases***doubted... used by GIs to quiet bowels....
|
|
|
NO WRT GI contractions
|
decreases.
|
|
|
Secretin intracellular mech
|
cAMP/Gs....
|
|
|
CCK intracell. mech
|
IP3/DAG ... increase Ca2+.... Gq.
|
|
|
Ach (vagal) intracellular mech
|
IP3/DAG ... increase Ca2+ ... Gq.
|
|
|
Vagotomy WRT pancreatic meal response...
|
block 60%.
|
|
|
Cystinuria
|
Dibasic AAs not absorbed
System BO+ AA transporter prob. tx with di and tripeps (e.g. arginyl-leucine). |
|
|
Hartnup's disease
|
Neutral AAs not absorbed.
System B AA transporter prob. tx with di and tripeps (e.g. phenylalinyl-leucine). |
|
|
Colipase
|
binds pancreatic lipase, prevents inhibition by BAs.
|
|
|
Cholesterol ester hydrolase
|
lipase in SI
"bile acid activated" |
|
|
PLA2
|
lipase in SI
"bile acid needed for maximum activity". |
|
|
FABP
|
on enterocytes, fatty acid binding proteins...
high affinity for long chain FA and their monoglyc... transport to SER. |
|
|
Zollinger-Ellison Syndrome effect on Lipid absorption/digestion...
|
recall ... gastrin secreting panc. tumor.
increases H+, therefore denature pancreatic enzymes (namely pancreatic LIPASE) |
|
|
Na absorption in the small and large bowel - 4 mechanisms:
|
Na channels
Na/solute cotransport. Na/Cl cotransport. Na/H ANTIPORT... |
|
|
What mechanism does VIP use?
|
Gs/cAMP
|
|
|
Secretagogues (2) that act via Guanylyn receptor and increase cGMP...
|
Guanylin
Heat-Stable enterotoxin |
|
|
Secretagogues (3) that act via Gq/Ca increase...
|
Seratonin, Ach, Histamine.
|
