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53 Cards in this Set
- Front
- Back
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Omeprazole
Lansoprazole |
H+ pump inhibitors
Interaction with CYP2C19, CYP3A4 (diazepam, warfarin) |
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Cimetidine
Famotidine |
H2 receptor antagonist
(cimetidine only) Anti-androgenic, higher estradiol levels compete with drugs metabolized by CYP 450 (lidocaine, diazepam) |
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MgO, NaHCO3, CaCO3, Al salts
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Antacids
Mg salts = diarrhea Al salts = constipation (often given together) Increase gastric pH, lower drug absorption |
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Propantheline
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Antimuscarinic, reduce gastric activity
IBS |
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Misoprostol
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Prostaglandins
Increase mucosal blood flow, mucus secretion Reduce histamine and acid secretion NSAID lesions |
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Clarithromycin
Amoxicillin Metronidazole |
Antibiotics
In combination w/ H+ pump inhibitors or H2 antagonist, H. pylori |
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Sodium alginate
Sucralfate |
Physical protectant of stomach
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Metoclopramide
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Gastroparesis
Dopamine receptor antagonist (D2) 5 HT3 antagonist Anti-emetic |
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Erythromicin
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Motilin agonist
Gastric irritant |
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Neostigmine
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AChE inhibitor
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Bethanecol
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Muscarinic receptor agonist
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Dimenhydrinate
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Dramamine
H1 antagonist Anti-cancer therapy |
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Odansentron
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Potent 5 HT3 antagonist
Anti emetic |
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Dronabinol
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cannabinoid
Anti emetic |
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Loperamide
Diphenoxylate |
Anti diarrheal
Opiate for parasitic disease |
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Bismuth subsalicylate
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coats irritated mucosa, binds toxins
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Kaolin - hydrated Aluminum silicate
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Anti diarrheal
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Psyllium, carbon polycarbophil, methylcellulose
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Fiber, bulking agent
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Laxatives
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Mineral oil
Castor oil polyethylene glycol Mg (OH)2 |
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Sulfasalazine
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IBD
metabolized to 5 aminosalicylate |
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Infliximab
Adalimumab |
Anti TNF alpha antibodies
IBD RA |
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IBS
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Anticholinergics
serotonin 5HT3 antagonists |
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IBD consideration
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Penicillin may aggravate
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Name 2 sialogogues
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Pilocarpine
Cevimeline |
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Name 4 anti sialogogues
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Atropine (anti diarrheal)
Scopolamine (anti emetic) Glycopyyrolate (anti GERD) Propantheline |
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Meclizine HCl
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Anti emetic
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Benzodiazepines
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Sedation, amnesia, anxiolysis, anticonvulsant
Occupy GABA receptor in brain |
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Midazolam
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Versed
3-4x potent to diazepam (valium) Hypotension, decreased respiratory rate, apnea |
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Diazepam
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Valium
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Alprazolam
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Xanax
8-10x potent to diazepam |
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Demerol
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Mepiridine
Narcotic |
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Fentanyl
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Sublimaze
100x potent to morphine Quick onset 100 micrograms |
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Propofol
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Diprivan (milk of amnesia)
Deep sedation |
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Robinul
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Glycopyrrolate
IV drug |
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Ketamine
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Angel Dust
Hallucinations Always use with Versed! |
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Naloxone
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opioid antagonist, reverse resp depression and sedation
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Flumazenil
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Binds GABA receptors to reverse benzodiazepines
Monitor patient for 1 hr after last dose |
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Atropine
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Anticholinergic - significant brachycardia or systole
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Ephedrine
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sympathomimetic
Hypotension |
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Fexophenadine
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H1 antagonist
non drowsy Allegra |
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Cromolyn
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Inhibitor of degranulation
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Diphenhydramine
Promethazine |
H1 receptor antagonist
Promethazine is anti-emetic |
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Azathioprine
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Forms 6 - MP --> thioinosinic acid
Lymphocyte specific inhibition In combination with corticosteroids and cyclosporine |
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Mycophenolic acid
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lymphocyte specific inhibition
In combination with corticosteroids and cyclosporine nausea, vomiting Some drugs interact with ENTEROHEPATIC CIRCULATION OR RENAL SECRETION OF DRUG |
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Cyclosporine
Tacrolimus |
Calcineurin inhibitors
Inhibit immunophilins - cyclophilin and FK506 binding protein Inhibit NUCLEAR FACTOR ACTIVATED CYTOKINE -> inhibit IL-2 CYP 450 3A ADRs: hypertenion, diabetogenic Ging hyperplasia for cyclosporine |
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Sirolimus
Everolimus |
mTOR inhibitors
Bind FK506 binding protein Block IL-2 induced activation Inhibit cell cycle Synergy w/ cyclosporine CYP 450 Sirolimus - NO KIDNEY OR LIVER TOXICITY MOUTH ULCERS, IMPAIRED WOUND HEALING |
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Polyclonal antibodies ATG, ALS, ALG
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Immunotherapy
profound lymphopaenia, long half life Risk of anaphylaxis and cytokine release syndrome in first dose |
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Monoclonal antibodies
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immunotherapy
cytokine release syndrome |
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Methotrexate
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anti-metabolite, anti-cancer
RA, psoriasis, teratogen |
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Cyclophosphamide
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Anti-cancer, DNA alkylating
vomit, nausea, carcinogen |
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Immunostimulants
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IFN, IL-2, IL-11, granulocyte or granulocyte/macrophage colony stimulating factor (G-CSF, GM-CSF)
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Basiliximab
Daclizumab |
Anti-IL 2r
Renal transplant |
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Corticosteroids
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Glucocorticoids
Reduction in macrophage, cytokines, MHC II expression Diabetogenic, impaired wound healing, suppressed immune system |
