Use LEFT and RIGHT arrow keys to navigate between flashcards;
Use UP and DOWN arrow keys to flip the card;
H to show hint;
A reads text to speech;
33 Cards in this Set
- Front
- Back
CTZ has what receptors
|
D2
5-HT H1 Opiod - Mu NK-1 (neurokinin) M1 (muscarinic) |
|
Vestibular vomiting center has what receptors
|
H1
M1 |
|
Acepromazine as GI drug
|
Primarily a phenothiazine - dopamine antagonist but also acts at H1
|
|
Phenothiazine
|
Acepromazine
|
|
Antiserotonin as GI drug
|
Blocks 5HT 3 (antagonist)
|
|
5HT3 antagonist
|
Ondansetron
|
|
Ondansetron
|
5HT antagonist
|
|
Moropitant
|
NK-1 antagonist
Approved for dogs acts centrally/peripherally Substance P inhibitor |
|
NK-1 receptor blocker
|
Moropitant
|
|
Metaclopramide
|
D2 antagonist, but also prokinetic
5HT-3 antagonist - vomiting 5HT-4 agonist |
|
Drugs that increase GI motility
|
Metoclopramide
Cisapride Bethanechol Lidocaine Domperidone |
|
Metoclopramide as prokinetic
|
Increases Ach release to increase smooth muscle contraction
early GI tract |
|
Bethanecol
|
Cholinergic agonist
Entire GI works elsewhere in body with many effects |
|
Cisapride
|
5HT 4 agonist
5HT3 antagonist |
|
Domperidone
|
Dopamine antagonist
|
|
Lidocaine
|
Na channel blocker
unknown MOA |
|
Acid suppressant drugs
|
H2 blockers
Cimetidine < Ranitidine < Famotidine |
|
Proton pump inhibitors
|
Omeprazole
|
|
Omeprazole
|
Proton pump inhibitor
continues working after blood levels have declined |
|
Magnesium hydroxide
|
neutralizes acidic pH
|
|
Protective GI drugs
|
Misoprosotol
Sucralfate |
|
PGE-1 analogue
|
Misoprosotol
Used with chronic NSAID use ADE: abortion |
|
Sucralfate
|
attaches to stomach
Need acidic environment to work so give before H2 suppressant |
|
Cimetidine side effect
|
inhibits cytP450
|
|
Cimetidine and Misoprotol don't _______ just _____.
|
treat ulcer
prevent it |
|
Decreases GImotility
|
Antimuscarinics
Atropine Glycopyrolate |
|
Anti-diarrheal drugs
|
Mu receptor
Opioid Loperamide Diphenoxylate |
|
Diphenoxylate
|
mu receptor agonist
Can cross to CNS, |
|
Diphenoxylate also has _______ to _____
|
atropine
prevent abuse |
|
Loperamide and Dipehnoxylate MOA
|
decreases motility
increases digestion Must also treat viral/baterial problems |
|
Loperamide is also called
|
immodium
|
|
Diphenoxylate
|
Lomatil
|
|
If you give too much atropine, glyco, or N-butyl what can you do
|
Bethanechol
But be aware of heart effects as well |