Gi

Front 1

antacids

Back 1

1. all decrease efficacy PPI
2. sodium bicarb: increase PUD
3. aluminum hydroxide + magnesium hydroxide = DOC
4. calcium carbonate: constipation

Front 2

H2 blocker

Back 2

1. itidine
2. competetive block parietal cell
3. decrease gastric secretion 70% 24h
4. cimetidine + warfarin increase bleeding
5. cimetidine inhibits CYP450

Front 3

PPI

Back 3

1. -prazole
2. faster than H2 blocker
3. irreversibly inhibit 90% for 48h
4. DOC for zollinger ellison
5. prodrug that need HCl for activatin
6. some H. pylori effect

Front 4

prostaglandin

Back 4

1. misoprostil
2. only use NSAID ulcer
3. C/I w/OC
4. PGE2 analog that decreases HCl
5. increase mucosal barrier via Gi

Front 5

mucosal protective

Back 5

1. adjuncts, never monotherapy
2. need acidic pH to activate
3. interfere with absorption other Rx
4 chelated bismuth produces black tarry stool while sucralte does not

Front 6

quadruple therapy

Back 6

1. PPI
2. ampicillin/tetracycline
3. clarithromycin/metronidazole
4. chelated bismuth

Front 7

bulk laxative

Back 7

1. psyllium, bran, methycellulose, fiber
2. indigestible
3. C/I in stool impaction

Front 8

saline/osmotic laxative

Back 8

1. presurgery, poisoning, impaction
2. contraindicated in volume overload (CHF)
3. work 1-3h
4. NaPO4, lactulose, Mg-salt, PE glycol

Front 9

1. stool softner/surfactant

Back 9

1. lubricate stool
2. docustate, mineral oil, glycerin suppository

Front 10

irritant/stimulant laxative

Back 10

1. not for elderly or non-healthy
2. castor, sena, bisocodyl, lubriprostone

Front 11

loperamide

Back 11

1. use diarrhea (cholera, some ecoli)
2. increase transit time
3. stim opoid receptors
4. poor CNS penetration
5. toxic megacolin if used in IBD

Front 12

scopalamine

Back 12

1. M1 antagonist
2. #1 OTC
3. C/I liver/renal dz, prostatitis, dysuria

Front 13

5-HT3 antagonist

Back 13

1. ondansetron, granisetron
2. work seconds, safe
3. cleared by kidney

Front 14

phenothiazines

Back 14

1. promethazine: H1 antagonist
2. prochlorperazine: D2 antagonist
3. antipsychotic meds w/neuroleptic SA
4. C/I liver dz, prostatitis, glaucoma

Front 15

IBD

Back 15

1. aminosalicylates
2. corticosteriod
3. thiopurine (azathiopurine, mercaptopurine)
4. methotrexate
5. cyclosporin
6. infliximab

Front 16

aminosalicylates

Back 16

1. cautionn renal, pregnancy, and breast feeding
2. may decrease colorectal caner
3. may cause pancreatitis

Front 17

prednisone

Back 17

1. decrease IL transcription
2. lymphocyte apoptosis
3. decrease AA metabolism

Front 18

thiopurine

Back 18

1. azathiopurine and mercaptopurine (chemo)
2. leucopenia
3. use w/steriod
4. t cell apoptosis, decrease ribonucleotides

Front 19

methotrexate

Back 19

1. use crohns when AZA cant be used
2. inhibit dihydrofolate reductase
3. decrease cytokines and eicosanoid synthesis

Front 20

cyclosporin

Back 20

1. prevent t cell clonal expansion
2. steriod sparing
3. renal impariment, neurotoxicity

Front 21

infliximab

Back 21

1. mAb to TNF
2. may reactivate TB
3. IV q 4-6w