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28 Cards in this Set

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components of lipoproteins
apoprotein & lipid in NON covalent bond

non-enzymatic rxn
lipid component of lipoproteins
cholesterol (30%)
cholesterol esters (70%)
TG's
PL's
beta Carotene & Fat sol vits
functionn of PL's in lipoprot's
essential for secretion of Cholesterol
function of lipoproteins
vehicle for lipid trspt
ligands- apo B 100/LDL
cofactor- ApoC II activate LpL
lipoprotein characteristics VLDL
high TG's
major cholesterol carrier
(from liver to tissues)
lipoprotein characteristics LDL
most cholesterol
returns chol to liver for bile & free cholesterol

apo B100 binds LDL R
lipoprotein characteristics HDL
progresses from A1 only to more CE
donates ApoCII & E to other lipoprots
Apo I binds ABCA1 to pick up FC
then LCAT esterifies cholest
(repeatedly) until HDL3 then 2
VLDL/LDL conversion
VLDL (after gaining apo CII & apo E) loses TG's to tissue (via lipase)
picks up CE from HDL via CETP
to IDL then LDL
delivers CE to tissues
SR-B1
sterol receptor
reverse cholesterol transport
in tissues & hepatocyte
cholesterol exchange w/HDL via apo A1
LDL R
in hepatocyte & tissue
recognizes B 100
LCAT
lecithin cholesterol acyl transferase
on HDL
esterifies FC (usually by linking to linoleic)
uses PC to lysoPC
made in liver & secreted
HDL picks up
possible theraputic approach w/HDL
increase t 1/2
stim RTC
decrease BMI (1:1 correlation)
increase apo A1 synth
statins & cholestyramine
ABCA 1
ATP binding cassette transporter
spans membrane of cells in tissues
cholesterol & PL efflux
tangiers dz
mutation in ABCA 1
chol in tissues
enzymes to free FAs from TGs in tissues
hepatic lipase
-CE in thru SRB 1 from HDL
-glycerol rlsd for TG synth or GNGen

lipoprotein lipase (LpL or LL)
-endothelial cell surface
-tethered by heparin SO4 (proteoglycan)
-VLDL & IDL give up FA's
activation of LpL
Apo C II (from HDL, donated to VLDL by HDL)

heparin-
-can cause hyperthermia during surgery b/c ACoA
CETP
cholesterol ester transfer protein
-synth'd by liver & fat cells
-exists bound to HDL
-increased synth in rsp to high chol diet
-concentration of CETP increases w/conc of LDL
-facil mvt of lipids & TGs from HDL to VLDL or LDL

CETP defic gives increased HDL & chol content of HDL
RCT
reverse cholesterol transport
-apo A from liver
-ABCA 1 (pick up FC)
-LCAT (esterify)

VLDL
-CETP extracts CE from HDL
-LpL frees FA's to tiss
-becomes LDL (few TG, many CE)
-return CE's to liver for bile or storage
intracellular lipoprotein enzyme
ACAT
- re esterify FC in liver
-(b/c CE rlsd from endolysosome via lysosomal acid lipase)
extracellular lipoprotein enzyme
LCAT
-activated by A1
-form cholesterol ester in HDL
-uses pcholine (lecithin)
-usually adds linoleic acid
lipoprotein enzymes
ACAT- intracell, hepcyte, esterify, LDL

LCAT- extracell, HDL, esterify, uses PC

Hepatic lipase
-assoc w/SR B1
-HDL receptor for deliver to liver
-FFA's & CE to hepatocyte

Lipoprotein Lipase
-assoc w/VLDL
-FFA's to tissues
-activated by apo C & heparin
lipoprotein transporters
SR B1- HDL, apo a1
-mvt FA in to liver
-assoc w/hepatic lipase

LDL R- LDL B100
-endocytose
-deliver chol to liver
-(also at tissues)

ABCA- HDL
-span tiss memb
-PL & FC to HDL

CETP - HDL
lipids & TG's to VLDL/LDL
increased HDL & increased cholesterol content of HDL
CETP deficiency
LpL activated by...
apo C (on VLDL, after HDL donated it)
intestinal uptake of cholesterol
Anx 2 & Caveolin 1
in enterocyte membrane
form pore
cholesterol goes thru

vitoran (stain + ezetimibe)
removes Anx 2
ezetimibe
componant of vitoran that removes Anx 2 (blocks chol absorption)
CVD risk
framingham
CRP
MPO (myeloperoxidase)
mechanism of LDL receptor
endocytosed
fuse w/lysosome
pump in H+
release free cholesterol
re-esterified by ACAT