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36 Cards in this Set
- Front
- Back
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product of GH target cells
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IGF-1
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GH agents
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somatropin
somatrem |
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clinical use of GH agents
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Anti-aging supplements
deficiency in children AIDS-wasting malabsorption (short bowel) |
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how does renal disease cause short stature
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decreased excretion of IGF BP
less active IGF |
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how does excess GH cause slipped capital femoral head
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weakens epiphyseal plate
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side effects of GH in adults
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arthralgia
carpal tunnel edema |
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composition of mecasermin
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recombinant IGF-1
recombinant IGFBP3 |
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clinical use of mecasermin
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primary IGF-1 deficiency
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side effects of mecasermin
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hypoglycemia
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GH antagonists
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lanreotide
octerotide pegvisomant cabergoline bromocriptine |
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somatostatin analogs
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octreotide
lanreotide |
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difference between somatostatin and octreotide
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octreotide has a longer half-life
45x more potent in reducing GH |
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clinical use of octreotide/lanreotide
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acromegaly (adults)
gigantism (children) carcinoid syndrome diarrhea from pancreatic VIPoma |
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side effects of octreotide/lanreotide
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biliary sludge/gall stones
hypo/hyper glycemia (inhibits insulin/glucagon) hypothyroidism (inhibits TSH) steatorrhea |
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GH receptor antagonist
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pegvisomant
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D2 agonists (high levels decrease GH release)
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bromocriptine
cabergoline |
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inhibits prolactin release
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dopamine
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dopamine agonists used to treat prolactinomas
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bromocriptine
cabergoline |
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how does a prolactinoma cause visual problems
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mass effect
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how does Turners cause short stature
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decreased estrogen causes decreased levels of IGF-1 BP and decreased IGF-1
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tx for turners syndrome
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GH
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amino acid that releases GH
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arginine (IV) - not orally
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who would get scoliosis and SCFE
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kids
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what endocrine disorders can occur with GH therapy
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hypothyroidism
insulin resistance |
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why does GH excess cause hypothyroidism
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increases somatostatin which blocks TSH
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side effect of GH in children
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scoliosis
slipped capital femoral head |
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normal GH
low IGF-1 what is problem and what tx |
GH receptor
IGF-1 |
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prevent hypoglycemia with mecasermin
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eat
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how does octreotide tx carcinoid syndrome and pancreatic vipoma
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hits somatostatin receptors on tumor to decrease hormone release
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why does prolactinoma cause amenorrhea, infertility, loss of libido
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high PRL inhibit release of GnRH
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what effect would cabergoline have on a pre-menopausal woman with a prolactinoma
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decrease PRL and restore ovulation
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side effect of dopamine agonists
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postural hypotension - vasodilation
digital vasospasm - alpha 1 |
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effect of GH on somatostatin
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increases it (insulin resistance and hypothyroidism)
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causes biliary sludge and gallstones
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octreotide/lanreotide
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prolactinoma drug that causes postural hypotension
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cabergoline
bromocriptine |
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prolactinoma drug that causes digital vasospasm
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cabergoline bromocriptine
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