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25 Cards in this Set
- Front
- Back
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antidote for atropine poisoning |
physostigmine |
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NO CNS entry |
physostigmine, pyridostigmine, edrophoniumm |
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acetylcholinesterase inhibitors |
tacrine, donepazil, rivastigmine, galantamine |
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what do drugs not do for Alzheimers dx and what do they attempt to do |
they do not delay progression, but attempt to decline slope of sx onset |
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neuroprotective agent used for moderate to severe AD |
memantine |
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rarely used acetylcholinesterase inhibitor d/t to hepatotoxicity |
tacrine |
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for how many months are AD drugs effective and in how many pts? |
drugs effective for 6-12 months for 50% of pt population |
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cholinergic hypothesis |
degeneration of basal forebrain nuclei leads to deficit in cholinergic transmission |
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drug that interacts with pseudocholinesterase so it's not AchE selective |
rivastigmine |
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acetylcholinesterase inhibitor w/ less risk of drug interaction |
rivastigmine |
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acetycholinesterase inhibitor w/ active metabolites |
donepezil |
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side effects of muscarinic activation from acetylcholinesterase inhibitors |
DUMBELS-defecation, urination, miosis, muscl weakness, bradycardia, bronchocorrea, bronchospasm, lacrimation, salivation, sweating |
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acetylcholinesterase inhibitors aggravate what conditions |
SSS, AV block, COPD, asthma, peptic ulcer, aspiration pneumonia, dehydration |
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drugs w/ good CNS entry |
donepezil, rivastigmine, galantamine |
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limited distribution and thus fewer adverse effects |
physostigmine, pyridostigmine, edrophoniumm |
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use of neostigmine, pyridostigmine, edrophoniumm |
reverse paralysis of nicotinic receptor antagonists |
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peripheral muscarininc SEs and somatic nicotinic SEs |
physostigmine |
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used to increase bladder and intestinal motility, reduce ocular pressure in glaucoma |
physostigmine |
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MOA memantine |
deals with repercussions of xs gluatmate by acting as NMDA receptor antagonist and preventing Calcium influx...taking place of Mg in ligand gated receptor |
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memantine should be dosed carefully in what type of pts? |
renal impaired |
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memantine can be used it pts with the following syndromes |
SSS, AV blocl, COPD, asthma, peptic ulcer |
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most effective therapy for agitation and psychosis in AD |
antipsychotics (atypicals), risperidone and olanzapine |
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black block warning on... |
risperidone and olanzapine (anti-psychotics)..increase risk of stroke |
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drugs with what kind of effects are geriatric pts very sensitive to? |
anti-muscarinic effects |
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anti-muscarinic effects includ |
constipation, urine retention, mydriasis, tachycardia, bronchodilation, anti-secretory, dry mouth, no sweating, and CONFUSION, DELERIUM |
