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20 Cards in this Set
- Front
- Back
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The overall structure of the connected nucleosomes resembles?
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Beads On a String
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The structure of the connected nucleosomes allows?
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The structure to shorten the DNA length about seven- fold
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Many human diseases are due to?
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Failure during DNA replication and/or repair
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About how big was the plasmid you purified in lab?
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5000 Base Pairs
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The duplication of the genome must be?
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Very Fast and Very Accurate
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What was Watson and Cricks suggestion for the way DNA replicates?
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Semi Conservative Replication
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What happens to the old strands of DNA after replication?
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Each old DNA strand becomes template for new complimentary strand synthesis
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What is the Enzyme that removes RNA primer during DNA synthesis?
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DNA Polymerase
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What are some properties if DNA polymerase?
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Cannot start new DNA synthesis, Requires primer and template, Polymerizes in one direction only, Proofreading, and can have many subunits
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DNA synthesis is known as?
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De Novo
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The primer and template for DNA polymerase?
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4 dNTPs, MG++
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DNA polymerizes DNA in the direction of?
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(5' to 3')
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What allows DNA polymerase to proofread?
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3' to 5' exonuclease
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Replication is?
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Bi- directional
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The leading and lagging strand problem?
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Can't polymerize continuously on both sides of replication fork, Reji Okazaki, and discontinuous synthesis of lagging strand
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The end replication problem is known as?
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Telomeres
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What has circular chromosomes and replicate them bidirectionally from a unique origin?
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Bacteria
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Big and Slow =?
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More Origins
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Short Telomeres =?
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Aging (senescence)
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Hutchinson Gilford Syndrome (progeria) is caused by?
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Short telomeres on their chromosomes
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