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10 Cards in this Set
- Front
- Back
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Genetic vs. Genomic Medicine
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-genetic: use of knowledge about single genes to improve diagnosis & treatment of single gene disorders
-genomic: key component of personalized medicine --> incorporates clinical, genetic, genomic & environmental info |
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What can genomic medicine tell us about drug dosage?
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How much to give to a person b/c of their genetic responses to it (moves away from one size fits all approach)
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Does genomic medicine move us away from the physical examination?
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NO
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In genomic medicine, the price of the genome is going _______, while technology is getting ________
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-down
-faster |
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Advantages of high-throughput sequencing (3)
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1) entire process automated
2) DNA is bound to solid support & multiple reactions can occur in parallel 3) multiple samples of patient DNA can be run using bar codes |
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How were the variants associated with disease in Steven Quake's genome organized?
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-rare variants associated with common diseases
-"common" variants with rare diseases |
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Why was Quake's genome significant?
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-3 rare variants associated with sudden death
-novel CFTR mutation -other variants associated with random shit |
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What might be the most practical application for sequencing the genome?
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specific information about drug doses
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How did they put together gene-environment correlations?
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by looking at variants & assuming some major conditions that he is at risk for --> what lifestyles would be bad/good for this
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What is the issue with sequencing the genome & finding all these variants?
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we don't really know what it means to have all these different variants (that is a big fear),
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