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15 Cards in this Set
- Front
- Back
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RAS
-type of mutation -type of cancer |
pt mutation
wide variety of cancers |
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RET
-type of mutation -type of cancer |
pt mutation
Multiple endocrine neoplasia familial thyroid carcinoma |
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BCR/ABL
-type of mutation -type of cancer |
translocation 9:22
Chronic Myelocytic Leukemia |
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C-Myc
-type of mutation -type of cancer |
translocation 8:14
Burkitt Lymphoma |
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N-Myc
-type of mutation -type of cancer |
Amplification
Neuroblastoma |
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Her-2
-type of mutation -type of cancer |
Amplification
Breast Cancer |
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Erb-B2
-type of mutation -type of cancer |
Amplfication
Breast Cancer |
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Cyclin D1
-type of mutation -type of cancer |
translocation 11:14
Mantle cell lymphoma |
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Rb
-cancer mechanism -type of cancer |
E2F (transcription factor) is free
Retinoblastoma |
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APC
-cancer mechanism -types of cancer |
Releases B-catenin (transcription factor)
FAP and sporadic CRC |
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What affect will overexpression of Bcl-2 have on a cell
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inhibit apoptosis
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Li Fraumeni is caused by mutation of what gene?
Does it require both genes to be mutated? |
TP53 (p53)
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FAP is caused by the mutation of what gene?
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APC
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BRCA1/BRCA2 mutations cause defects in what?
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DNA repair, especially DSBs
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Male breast cancer can be caused by BRCA1 or BRCA2?
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2
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