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82 Cards in this Set
- Front
- Back
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CD10+, CD19+, CD20+
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Burkitt's Lymphoma, Follicular Lymphoma, DLBCL if derived from Follicular Lymphoma
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Pax5
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t(14;19) Lymphplasmacytoid Lymphoma
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CD15+, CD30+, CD45-, EBV+
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Mixed Cellularity Hodgkins Lymphoma
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BCL2
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t(14;18) Follicular Lymphoma and sometimes DLBCL
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CD2+, CD3+, CD4+, CD7+, (CD4+/8+)
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T Cell Prolymphocytic Leukemia
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CD45-, CD15+, CD30+, EBV-
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Nodular Sclerosing HL
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CD11c/CD19+, CD22+, CD103+, CD25+
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Hairy Cell Leukemia
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CD5+, CD19+, CD20+, CD23-
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Mantle Cell Lymphoma
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BCL6
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t(3;X) Large Cell Lymphoma
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CD19+, CD20+
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DLBLC
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CD20+, CD15-, CD30-, CD45+, EBV-
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Nodular Lymphocytic Predominant HL
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CD2+, CD3+, CD5+, CD7-
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Peripheral T Cell Leukemia
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C-MYC
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t(8;14) Burkitt's Lymphoma
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BCL1
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t(11;14) Mantle Cell Lymphoma; overexpression of cyclin D
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NPM/ALK
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t(2;5) Anaplastic Large Cell Lymphoma
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BCR-ABL
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t(9;22); Ph chromosome, CML (good prognosis), ALL (bad prognosis)
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CBF-alpha
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t(8;21); AML-M2; AML1-ETO fusion
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TEL-AML1
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t(12;21) B-ALL
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CBF-beta
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inv(16), AML-M4
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PML-RAR gene and chromosome
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t(15;17) AML-M3
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CD13+, CD33+
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AML
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13q14
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good prognosis for CLL/SLL
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5q-
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Good prognosis for MDS
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Trisomy 12
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Bad prognosis for CLL/SLL and Multiple myeloma
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Del 11q
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Bad prognosis for CLL/SLL
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Del13q
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Bad prognosis for CLL/SLL and multiple myeloma
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Del17p
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Bad prognosis for CLL/SLL
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Bad prognosis for CLL/SLL
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Trisomy 12, Del 11q, Del 13q, Del 17p
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CD38+
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Bad Prognosis for CLL/SLL
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CD38-
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Good prognosis for CLL/SLL
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ZAP 70-
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Good prognosis for CLL/SLL
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ZAP 70+
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Bad prognosis for CLL/SLL
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Treatments for Hairy Cell Leukemia
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IFN-alpha, Chemo with 2 cda, rituximab
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Cytoplasmic mu+, CD10+/-
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pre-B ALL
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CD1a, CD7, cCD3
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T-ALL
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Treatment for CLL/SLL
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Rituximab
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Stain for AML
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Myeloperoxidase, Sudan Black
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Stain for Hairy Cell Leukemia
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TRAP (acid phosphatase)
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Leukemias/Lymphomas with no adenopathy
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Prolymphocytic, Hairy Cell Leukemia
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Precedes Adult T cell leukemia
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HTLV-1
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Which lymphoma/leukemias present with eosinophilia
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CML (chronic phase), Hodgkin's Lymphoma (nodular sclerosing)
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CD3+, CD8+
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T-Cell Large Granular Lymphocytic Leuukemia
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CD16+, CD 56
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NK Cell Large Granular Lymphocytic Leukemia
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Alcohol induced pain
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Key sx of Hodgkin's Lymphoma
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Important types of NHL
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Burkitt's Lymphoma
Follicular Lymphoma Mantle Cell Lymphoma Anaplastic Large Cell Lymphoma |
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Starry Sky Appearance
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Burkitt's Lymphoma
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Treatment for DLBCL
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CHOP
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T cell non-Hodgkin's Lymphomas
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Angio-Immunoblastic lymphadenopathy, Mycosis Fungoides, Sezary Syndrome, ATLL, T-cell Intestinal Lymphoma, Anaplastic Large Cell Lymphoma
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Monosomy 13 del(13q)
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Multiple Myeloma, Poor prognosis
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Roleaux Formation in lymphoma/leukemia
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Multiple Myeloma
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monosomy 13
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Poor prognosis in Multiple Myeloma and CLL/SLL
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Most common Ig in Multiple Myeloma? 2nd most common?
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IgG (60%), IgA (30%)
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What does PML-RAR-alpha do?
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In AML-M3, it acts as a transcriptional repressor --> arrest of cellular differentiation
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Another name for CBF-alpha.
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AML1. It combines with ETO in AML-M2. (AML is on chromosome 21, ETO is on 8). Fuses to TEL on chromosome 12 in ALL.
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Another name for CBF-beta
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MYH11
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What role does immunidifficiency play in NHL?
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B cell lymphomas at unusual sites (like CNS)
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Gluten-induced enteropathy
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T cell lymphoma
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Role of EBV with leukemia/lymphomas?
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Burkitt's Lymphoma
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Same as tissue phase of CLL
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SLL (lymphocytic lymphoma)
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What do Marginal Zone lymphomas arise from?
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Often inflammatory or auto-immune d/o
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What can DLBCL arise from
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Marginal Zone lymphoma or Follicular lymphoma
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What is another name for marginal zone lymphomas
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MALTomas
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What is EBV associated with
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Burkitt's Lymphoma, DLBCL, Hodgkin's (all but lympho predominant)
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Is Sezary Syndrome B or T Cell?
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T Cell
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What are the 3 important diagnostic features found in multiple myeloma?
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Lytic bone lesions
Bence-Jones proteins in urine, or mAB in serum Increased plasma cells in BM (>20%) 2 of the 3 must be present |
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What do multiple myeloma cells secrete that leads to bone complications?
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IL-6
OAF (osteoclast activating factor) - contributes to bone lesions TNF - contributes to bone lesions IL-1 |
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Del(13q)
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Multiple Myeloma; poor prognosis
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What activates the osteoclasts in multiple myeloma?
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MIP-1-alpha and RANKL (cytokines that are osteoclast activating factors)
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Main Features of MDS?
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Trilineage dyspoiesis
Ringed sideroblasts Ineffective hematopoiesis BM fibrosis Abnormal MK |
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How many blasts = low risk MDS? High risk MDS?
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<5%
>5% |
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when is Sezary syndrome seen?
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NHL
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Waldenstrom's macroglobulinemia
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feature of Lymphoplasmacytoid lymphoma
see monoclonal IgM |
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which cancer has overexpressions of cyclin D1
what is the gene rearrangement |
Mantle Cell lymphoma
t(11;14) |
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tx for DLBCL
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cHOP
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mycosis funguoides
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type of T cel, NHL
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morph of mycosis fungoides
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epidermis and dermis infiltrated by neoplastic T cells with cerebriform nuclei
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bone lesions in Waldenstrom's macroglobulinemia
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none!
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clover leaf nuclei seen in?
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adult T cell leukemia/lymphoma
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What is plasmacytoid lymphocyte
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B cell neoplasm of lymphoid cells of an intermediate stage between lymphos and plasma cells
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hyperviscosity syndrome
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complication seen in Waldenstrom macroglobulinemia
results from marked increase in IgM |
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most common form of NHL
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follicular lymphoma
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Marker on RS cells
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CD 15
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