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52 Cards in this Set

  • Front
  • Back
DNA viruses
Hepadna, herpes, adeno, parvo, papova, pox
RNA viruses
picorna, calici, reo, flavi, toga, retro, corona, orthomyxo, paramyxo, rhabdo, filo, arena, bunya, delta
Hepanda
enveloped; DS- partial circular
HBV; has a reverse transcriptase
Herpes
HSV, VZV, EBV, CMV, HHV 6 (roseola), HHV 8- Kaposis
enveloped, linear DS
Adeno
NO envelope; DS linear
febrile pharngitis, pneumonia, conjunctivitis, diarrhea
Parvo
No envelope; SS linear
B19- aplastic crisis in sickle cell disease, "slapped cheek" rash, erythemia infectiosum, hydrops fetalis
Papova
No envelope; DS circular; HPV warts, CIN, cervical cancer
JC- progressive multifocal leukoencephalopathy (PML) in HIV
Cancer: 16 and 18
kiolocytes- cytoplasmic clearing
Pox
Envelope; DS- linear
small pox, cow pox from infected cow udders
molluscum contagiosum- raised lesion with central divot, flesh colored
Picorna
No envelope, SS linear, icosahedral
Polio- ant horn of SC
Echo- aspetic meningitis, mild, from pools
Rhino- common cold
Coxsackie- aseptic meningitis, HFM, febrile pharnygitis, myocarditis
HAV
calici
no envelope, SS linear, icosahedral
HEV and Norwalk-cruiseship GE
Reo
no envelope, DS linear, segmented, icosahedral- Reo and Rota- wintery watery diarrhea
Flavi
envelope, SS linear, icosahedral
HCV
Yellow fever
WNV- from birds, muscle weakness, paralysis, anterior horn SC
SLE
Toga
envelope, SS linear, icosahedral
rubella
equine encephalitis
Retro
envelope, SS linear, icosahedral
have reverse transcriptase, HIV-AIDS, HTLV-T cell leukemia
Corona
envelope, SS linear, helical
Common cold and SARS- fever, cough, suspected exposure, positive lab assay or pneumo/ARDS w/o known cause
Orthomyxo
enveloped, SS linear segmented, helical
Influenza
Paramyxo
enveloped, SS linear, helical
Parainfluenza- croup- barking seal cough, inspiratory wheezes, steeple sign
RSV- brassy cough, looks like pneumonia
Measles
Mumps
Rhabdo
enveloped, SS linear, helical
Rabies
Filo
enveloped, SS linear, helical, hemorrhagic fever
arena
enveloped, SS linear, helical- LCV, meningitis
Bunya
enveloped, SS linear, helical
Hanta- hemorrhagic fever, pneumonia, rodent resevoir
Delta
enveloped, SS circular, helical, HDV
negative stranded
arena, bunya, paramyxo, orthomyxo, filo, rhabdo
must transcribe negative to positive
Killed vaccines
rabies, influenza, salk, HAV
Egg based vaccines
Flu, MMR, yellow fever
Reassortment
when viruses with segmented genomes exchange segments; worldwide pandemics
Recombination
exchange of genes between 2 chromosomes by crossing over within regions of significant base homology
complementation
when 1 of 2 viruses that infect the cell has a mutation that results in a nonfunctional protein; the nonmutated virus complements the mutated one by making a functional protein that serves both viruses
Amantidine mechanism
blocks viral penetration and uncoating; release of dopamine from intact nerve terminals (parkinsons tx)
uses and toxicity of amatidine
Influ A, Parkinsons
causes ataxia, dizziness, slurred speech
zanamivir, oseltamivir
DOC avian flu
inhibit influenza neuraminidase
used for influ A and B
ribavarin
inhibits synthesis of guanine nucleotides by competitively inhibiting IMP dehydrogenase
used for hep C
causes hemolytic anemia, severe teratogen
Acyclovir, valacylovir, famcyclovir
preferentially inhibits viral DNA pol when phosphorylated by viral thymidine kinase
used in HSV, VZV, EBV, mucocutaneous and genital herpes lesions
tox: delirium, tremor, nephrotox
Gancyclovir
phosphorylated by viral kinase; preferentially inhibits CMV DNA pol
tox: leukopenia, neutropenia, TCP, renal tox
Foscarnet
viral DNA pol inhibitor that binds to the pyrophosphate binding site of the enzyme; does not require activation by viral kinase
used in CMV or HSV
Protease inhibitors
saquinavir, ritonavir, indinavir, nelfinavir, amprenavir
PI mechanism, tox
inhibit assembly of new virus by blocking protease in progeny virions
GI intolerance, hyperglycemia, lipodystrophy, TCP, inhibit P450
NRTI
zidovudine (AZT), didanosine (ddI), zalcitabine (ddC), stavudine (d4T), lamivudine (3TC), abacavir
NNRTI
nevirapine, efavirenz, delavirdine
(direct and noncomp)
toxicity of RTI
bone marrow suppression, peripheral neuropathy, lactic acidosis, rash, megaloblastic anemia (AZT)
start HIV therapy
when CD4 < 200
CD4 < 350 + sxs
CD4 > 350, viral load > 100K or if CD4 rapidly decreasing
occupational exposure
zidovudine and lamivudine
HAART
zidovudine, lamivudine, effavirenz/PI
2 PPIs + 1 other
pregnancy
zidovudine
IFNa
chronic hep B and C, Kaposis
IFN beta
MS
IFN gamma
NADPH oxidase deficiency
SE lactic acidosis
NRTIs (zido, didan, stavu)
SE GI intolerance
protease inhibitors, zido
SE pancreatitis
didanosine, zalcitabine, stavudine, ritonavir
SE peripheral neuropathy
didano, zalcita, stavu
SE bone marrow suppression
zido