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61 Cards in this Set
- Front
- Back
Is the anus involved in Ulcerative Colitits (UC)?
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No
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Are there skip lesions in UC?
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No, it’s continuous
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Which anatomic structure is always involved in UC?
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Rectum
*Usually does not involve the ileum |
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Signs & symptoms of UC
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1) Bloody diarrhea (chronic)
2) Abdominal pain 3) Fever 4) Weight loss |
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Microorganism causing infection that may mimic appendicitis
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Yersinia enterocolitica
*Causes acute ileitis, RLQ pain, and diarrhea |
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Diagnostic test for UC
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Flexible sigmoidoscopy
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Backwash ileitis
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Seen in UC when there’s proximal colonic involvement and terminal ileum is affected by ulceration
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Medical treatment of UC
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1) Sulfasalazine (SE: affects sperm count and motility)
2) Mesalamine (Sulfa + 5-ASA) 3) Steroids **If medical tx fails, total proctocolectomy must be performed |
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Extraintestinal manifestations of inflammatory bowel disease
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1) Arthritis
2) Eye involvement (uveitis, iritis) 3) Apthous ulcers 4) Erythema nodosum 5) Pyoderma gangrenosum 6) Ankylosing spondyliitis / sacral ileitis 7) Primary sclerosing cholangitis (UC) |
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Surgical indications for UC
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1) Hemorrhage
2) Toxic megacolon 3) Failed medical management 4) Cancer prophylaxis in long-standing disease |
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Diverticuli
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Herniations of mucosa through the colon wall at sites where arterioles enter the muscular wall
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MC symtpom of Diverticulosis
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Hemorrhage
*Usually presents as bright red blood per rectum |
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Diverticulitis
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Infection and inflammation of colonic serosa
*Results from small perforations in diverticulum with fecal contamination |
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Symptoms of Diverticulitis
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1) LLQ pain
2) Abdominal pain 3) Fever 4) Chills 5) Alterations in bowel habits *Usually not associated with bleeding |
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MCC of bowel obstruction in pregnancy
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Sigmoid volvulus
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Plain radiographs of abdomen with volvulus
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Shows U-shaped loop in lower abdomen
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Often both diagnostic and therapeutic for sigmoid volvulus
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Sigmoidoscopy
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Why is sigmoid resection done following volvulus reduction and bowel compression?
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There is a 40% rate of recurrence without operative intervention
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Which is the MC site of colonic rupture?
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Cecum
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Branches of the superior mesenteric artery
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1) Ileocolic
2) Right colic 3) Middle colic *Supplies colon from cecum to splenic flexure |
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Branches of inferior mesenteric artery
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1) Left colic
2) Sigmoidal 3) Superior rectal *Supplies descending and sigmoid colon and upper rectum |
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Provides collateral blood flow between superior and inferior mesenteric arteries
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Arc of Riolan
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Dentate line
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Squamocolumnar junction between the rectum and the anus
Surrounded by muscular sphincter |
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Innervation of external anal sphincter
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Inferior rectal branch of pudendal nerve
Perineal branch of 4th sacral nerve |
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True or False: Adenomatous polyps of the colon have no significant malignant potential.
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False; they have significant malignant potential
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Overall incidence of carcinoma in Tubular adenomas
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15%
*Increasing size results in increased incidence of cancer |
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Do Villous adenomas have more or less propensity for malignant change compared to tubular adenomas?
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More; they are generally larger
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The degree of malignant potential in Tubulovillous adenomas is directly related to...
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The percentage of the villous component
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Benign lesions of the colon & rectum
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1) Hyperplastic polyps
2) Inflammatory polyps 3) Juvenile polyps or hamartomatous polyps |
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Peutz-Jeghers Syndrome
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Autosomal dominant syndrome
Multiple hamartomatous polyps Melanin deposits in buccal mucosa, palms and feet |
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Treatment of adenomatous polyps
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Colonoscopic resection with pathologic examination for foci of carcinoma
*F/u colonoscopy in 3 - 5 years for complete resection |
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Genetic risk factors associated with adenocarcinoma of the colon
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1) Nonpolyposis inherited colon cancer (Lynch Syndrome)
2) Familial adenomatous polyposis syndromes (FAPs) 3) Many familial colon cancers |
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Characteristics of Lynch Syndrome
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1) Right-sided colon cancer in young patients w/o multiple polyps
2) Autosomal dominant 3) Chromosome 18 *Type I: Colon cancer only *Type II: Several cancers |
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Characteristics of FAPs
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1) Multiple colonic polyps by age 30
2) Autosomal dominant 3) Chromosome 5 (q21): APC gene |
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Phenotypic subtypes of FAPs
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1) Familial polyposis coli
2) Gardner's syndrome (epidermal inclusion cysts, colonic polyps, osteomas) 3) Turcot syndrome (colonic polyps and brain tumors) |
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Protective factors against adenocarcinoma of the colon
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1) High fiber diet
2) Aspirin 3) Selenium 4) Thioesters 5) Carotenoids |
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The colon can be inspected by:
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Digital rectal exam - distal 8 cm
Flexible sigmoidoscopy - distal 60 cm Proctosigmoidoscopy - distal 20-25 cm (done in office) Colonoscopy - entire colon and distal ileum |
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Resection approaches after surgical treatment of colon cancer
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1) Resection with primary anastomosis
2) Resection with creation of colostomy **Reanastomosis of bowel after colostomy at or after 6 weeks |
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Current chemotherapeutic agents for colon adenocarcinoma
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1) 5-Fluorouracil
2) Levamisole |
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Indications for chemotherapy for colon adenocarcinoma
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Stage III colon cancer
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True or False: Radiation therapy is important in the treatment of colonic adenocarcinoma
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False; it is generally not used
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Abdominoperineal resection
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Used for lower rectal lesions
*Anal canal below level of sphincter is excised along with the rectum with formation of sigmoid colostomy |
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True or False: Radiation therapy is important in the treatment of rectal tumors
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True;
Preoperatively: reduce tumor mass Postoperatively: decrease rate of recurrence |
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Presentation of SCC of the anus
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1) Pruritus
2) Bleeding 3) Palpable mass |
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Cecal volvulus may present with symptoms of what intestinal disorder?
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Small bowel obstruction
**Accounts for less than 20% of colonic volvulus |
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Plain radiographs of cecal volvulus
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Kidney bean-shaped, air-filled cecum located in LUQ
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Treatment of choice to avoid recurrence of cecal volvulus
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Right hemicolectomy
**Operative detorsion with cecopexy associated with recurrence |
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Anal fissure
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Split in the anoderm
Either anterior or posterior (90%) midline |
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Recurrent or lateral anal fissures raise suspicion of what disease?
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Crohn's disease
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Symptoms associated with fissures
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1) Painful defecation
2) Bleeding from rectum *Pain in fissure causes internal sphincter spasm and further tearing |
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Treatment of anal fissures
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90% heal with stool softners, laxatives, and warm sitz baths
*Surgical repair may include sphincterotomy |
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Signs & Symptoms of anorectal abscess
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1) Severe anal pain
2) Fever 3) Urinary retention 4) (Occasionally) Sepsis 5) Palpable mass on DRE |
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MCC of anal fistula
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Spontaneous drainage of anorectal abscess
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Goodsall's Rule
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Fistulae with external opening posterior to bisecting line have internal openings in the midline.
Those anterior to the line have internal openings connecting via a straight line. |
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Pilonidal Disease
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Sinus or abscess formation in the skin over the sacrococcygeal junction
May be 2ndary to hairs driven into the skin Acute infection: pain and swelling Treated with I&D |
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Internal hemorrhoids
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Found above the dentate line, covered by mucosa
Rarely cause pain Painless bleeding and prolapse |
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External hemorrhoids
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Distal to dentate line, covered by sensate squamous epithelium
Perianal pain, itching, and swelling |
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Treatment of hemorrhoids
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1) Fiber diet, stool softeners, no straining
2) Rubber-band ligation (insensate internal hemorrhoids) 3) Sclerosis and cryosurgery 4) Excisional hemorrhoidectomy (symptomatic external hemorrhoids) |
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Rectal prolapse
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Complete intussusception of the rectum through the anus
**Involves all layers of the rectum |
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Treatment of rectal prolapse
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Rectopexy (fixation of the rectum)
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Crypt abscesses: Crohn's or UC?
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UC
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