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61 Cards in this Set

  • Front
  • Back
Is the anus involved in Ulcerative Colitits (UC)?
No
Are there skip lesions in UC?
No, it’s continuous
Which anatomic structure is always involved in UC?
Rectum
*Usually does not involve the ileum
Signs & symptoms of UC
1) Bloody diarrhea (chronic)
2) Abdominal pain
3) Fever
4) Weight loss
Microorganism causing infection that may mimic appendicitis
Yersinia enterocolitica
*Causes acute ileitis, RLQ pain, and diarrhea
Diagnostic test for UC
Flexible sigmoidoscopy
Backwash ileitis
Seen in UC when there’s proximal colonic involvement and terminal ileum is affected by ulceration
Medical treatment of UC
1) Sulfasalazine (SE: affects sperm count and motility)
2) Mesalamine (Sulfa + 5-ASA)
3) Steroids
**If medical tx fails, total proctocolectomy must be performed
Extraintestinal manifestations of inflammatory bowel disease
1) Arthritis
2) Eye involvement (uveitis, iritis)
3) Apthous ulcers
4) Erythema nodosum
5) Pyoderma gangrenosum
6) Ankylosing spondyliitis / sacral ileitis
7) Primary sclerosing cholangitis (UC)
Surgical indications for UC
1) Hemorrhage
2) Toxic megacolon
3) Failed medical management
4) Cancer prophylaxis in long-standing disease
Diverticuli
Herniations of mucosa through the colon wall at sites where arterioles enter the muscular wall
MC symtpom of Diverticulosis
Hemorrhage
*Usually presents as bright red blood per rectum
Diverticulitis
Infection and inflammation of colonic serosa
*Results from small perforations in diverticulum with fecal contamination
Symptoms of Diverticulitis
1) LLQ pain
2) Abdominal pain
3) Fever
4) Chills
5) Alterations in bowel habits
*Usually not associated with bleeding
MCC of bowel obstruction in pregnancy
Sigmoid volvulus
Plain radiographs of abdomen with volvulus
Shows U-shaped loop in lower abdomen
Often both diagnostic and therapeutic for sigmoid volvulus
Sigmoidoscopy
Why is sigmoid resection done following volvulus reduction and bowel compression?
There is a 40% rate of recurrence without operative intervention
Which is the MC site of colonic rupture?
Cecum
Branches of the superior mesenteric artery
1) Ileocolic
2) Right colic
3) Middle colic

*Supplies colon from cecum to splenic flexure
Branches of inferior mesenteric artery
1) Left colic
2) Sigmoidal
3) Superior rectal

*Supplies descending and sigmoid colon and upper rectum
Provides collateral blood flow between superior and inferior mesenteric arteries
Arc of Riolan
Dentate line
Squamocolumnar junction between the rectum and the anus
Surrounded by muscular sphincter
Innervation of external anal sphincter
Inferior rectal branch of pudendal nerve
Perineal branch of 4th sacral nerve
True or False: Adenomatous polyps of the colon have no significant malignant potential.
False; they have significant malignant potential
Overall incidence of carcinoma in Tubular adenomas
15%

*Increasing size results in increased incidence of cancer
Do Villous adenomas have more or less propensity for malignant change compared to tubular adenomas?
More; they are generally larger
The degree of malignant potential in Tubulovillous adenomas is directly related to...
The percentage of the villous component
Benign lesions of the colon & rectum
1) Hyperplastic polyps
2) Inflammatory polyps
3) Juvenile polyps or hamartomatous polyps
Peutz-Jeghers Syndrome
Autosomal dominant syndrome
Multiple hamartomatous polyps
Melanin deposits in buccal mucosa, palms and feet
Treatment of adenomatous polyps
Colonoscopic resection with pathologic examination for foci of carcinoma

*F/u colonoscopy in 3 - 5 years for complete resection
Genetic risk factors associated with adenocarcinoma of the colon
1) Nonpolyposis inherited colon cancer (Lynch Syndrome)
2) Familial adenomatous polyposis syndromes (FAPs)
3) Many familial colon cancers
Characteristics of Lynch Syndrome
1) Right-sided colon cancer in young patients w/o multiple polyps
2) Autosomal dominant
3) Chromosome 18

*Type I: Colon cancer only
*Type II: Several cancers
Characteristics of FAPs
1) Multiple colonic polyps by age 30
2) Autosomal dominant
3) Chromosome 5 (q21): APC gene
Phenotypic subtypes of FAPs
1) Familial polyposis coli
2) Gardner's syndrome (epidermal inclusion cysts, colonic polyps, osteomas)
3) Turcot syndrome (colonic polyps and brain tumors)
Protective factors against adenocarcinoma of the colon
1) High fiber diet
2) Aspirin
3) Selenium
4) Thioesters
5) Carotenoids
The colon can be inspected by:
Digital rectal exam - distal 8 cm
Flexible sigmoidoscopy - distal 60 cm
Proctosigmoidoscopy - distal 20-25 cm (done in office)
Colonoscopy - entire colon and distal ileum
Resection approaches after surgical treatment of colon cancer
1) Resection with primary anastomosis
2) Resection with creation of colostomy

**Reanastomosis of bowel after colostomy at or after 6 weeks
Current chemotherapeutic agents for colon adenocarcinoma
1) 5-Fluorouracil
2) Levamisole
Indications for chemotherapy for colon adenocarcinoma
Stage III colon cancer
True or False: Radiation therapy is important in the treatment of colonic adenocarcinoma
False; it is generally not used
Abdominoperineal resection
Used for lower rectal lesions

*Anal canal below level of sphincter is excised along with the rectum with formation of sigmoid colostomy
True or False: Radiation therapy is important in the treatment of rectal tumors
True;
Preoperatively: reduce tumor mass
Postoperatively: decrease rate of recurrence
Presentation of SCC of the anus
1) Pruritus
2) Bleeding
3) Palpable mass
Cecal volvulus may present with symptoms of what intestinal disorder?
Small bowel obstruction

**Accounts for less than 20% of colonic volvulus
Plain radiographs of cecal volvulus
Kidney bean-shaped, air-filled cecum located in LUQ
Treatment of choice to avoid recurrence of cecal volvulus
Right hemicolectomy

**Operative detorsion with cecopexy associated with recurrence
Anal fissure
Split in the anoderm
Either anterior or posterior (90%) midline
Recurrent or lateral anal fissures raise suspicion of what disease?
Crohn's disease
Symptoms associated with fissures
1) Painful defecation
2) Bleeding from rectum

*Pain in fissure causes internal sphincter spasm and further tearing
Treatment of anal fissures
90% heal with stool softners, laxatives, and warm sitz baths

*Surgical repair may include sphincterotomy
Signs & Symptoms of anorectal abscess
1) Severe anal pain
2) Fever
3) Urinary retention
4) (Occasionally) Sepsis
5) Palpable mass on DRE
MCC of anal fistula
Spontaneous drainage of anorectal abscess
Goodsall's Rule
Fistulae with external opening posterior to bisecting line have internal openings in the midline.
Those anterior to the line have internal openings connecting via a straight line.
Pilonidal Disease
Sinus or abscess formation in the skin over the sacrococcygeal junction
May be 2ndary to hairs driven into the skin
Acute infection: pain and swelling
Treated with I&D
Internal hemorrhoids
Found above the dentate line, covered by mucosa
Rarely cause pain
Painless bleeding and prolapse
External hemorrhoids
Distal to dentate line, covered by sensate squamous epithelium
Perianal pain, itching, and swelling
Treatment of hemorrhoids
1) Fiber diet, stool softeners, no straining
2) Rubber-band ligation (insensate internal hemorrhoids)
3) Sclerosis and cryosurgery
4) Excisional hemorrhoidectomy (symptomatic external hemorrhoids)
Rectal prolapse
Complete intussusception of the rectum through the anus

**Involves all layers of the rectum
Treatment of rectal prolapse
Rectopexy (fixation of the rectum)
Crypt abscesses: Crohn's or UC?
UC