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27 Cards in this Set
- Front
- Back
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How do you calculated the therapeutic index?
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LD50/ED50
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On what receptor does clonidine act?
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A2, decreases afterload and preload.
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On what receptors does propranolol, metoprolol and labetalol act?
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Propanolol - B1 and B2
Metoprolol - B1 Labetelol - everything |
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SV (EDV-ESV) x HR =
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CO
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Epinephrine acts on both alpha and beta receptors. What is the effect on blood pressure?
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At physiologic doses, B2 overpowers and bp drops. At pharmacologic doses, a1 overpowers and bp rises.
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What is used for paracetamol overdose?
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N-acetylcystein.
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What is used for salicylate overdose?
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NaHCO3 (alkalize urine)
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What is used for amphetamine overdose?
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NH4Cl (acidify urine)
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What is used for antimuscarinic / anticholinergic overdose?
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Physostigmine salicylate
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What is used for digitalis overdose?
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Tx: Stop Dig
Normalize K+ Lidocaine Anti-dig Fantibody Fragments Mg 2+ |
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What is used for lead poisoning?
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Dimercapol and EDTA 1st line of treatment. Succimer for kids.
It “sucks” to be a kid who eats lead. |
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What are signs and symptoms of lead poisoning?
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Lead Lines on gingivae and on epiphyses of long bones on X-ray.
Encephalopathy and Erythrocyte basophilic stippling Abdominal colic and sideroblastic Anemima Drops – wrist and foot drop. |
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What is used for methanol and ethylene glycol overdose?
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fomepizole
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What is used for opoid overdose?
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naloxone
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What is used for benzo overdose?
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Flumazenil
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What is used for heparin overdose?
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protamine
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What is used for warfarin overdose?
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vit. K and plasma
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Which drugs can cause photosensitivity?
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Sulfonamides
Amiodarone Tetracycline |
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What are some CYP-450 inhibitors?
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Isoniazid (INH)
Sulfonamides Cimetidine Ketoconazole Erythromycin Grapefruit juice |
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What is a major side effect of chloramphenicol?
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gray baby syndrome!
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What are some CYP-450 inducers?
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Quinidine
Barbiturates Phenytoin Rifampin Griseofulvin Carbamazepine St. John’s Wort Queen Barb takes Phen-phen and Refuses Greasy Carb Shakes |
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What are some drugs that can cause hemolysis in G6PD patients?
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Isoniazid (INH)
Sulfonamides Primaquine Aspirin Ibuprofen Nitrofurantoin (hemolysis IS PAIN) |
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What are some drugs that can cause SLE-like syndrome?
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Hydralazine
INH Procainamide Phenytoin It’s not HIPP to have Lupus |
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What drug can cause tendonitis, tendon rupture & cartilage damage in kids?
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Fluoroquinolones
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Which drugs is associated with interstitial nephritis?
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Methicillin
NSAID’s PPIs |
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Which drugs are commonly associated with pulmonary fibrosis?
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Bleomycin
Busulfan Amiodorane |
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What are some signs and symptoms of steroid withdrawal?
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Tachycardia, tachypnea, low blood sugar, abdominal pain, , weakness, nausea and lethargy.
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