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13 Cards in this Set

  • Front
  • Back
What is the etiology of MS
Autoimmune disease

Destruction of myelin in the CNS
What are the different types?
Relapsing remitting
Primary progressive
Secondary Progressive
Progressive Relapsing
What are the early signs of MS?
Optic neuritis
Fatigue
Weakness
Balance deficits/Cerebellar signs
What is required for a Dx of MS
Dissemination of time and space
Decreased latency of evoked potentials
IgG in the CSF >15%
What does a high score on the EDSS mean?
10=death
1= normal
Explain the components of the EDSS
Motor function
Cerebellar Function
Brainstem function (CN)
Sensory fucntion
Bowel and Bladder
Visual
Cerebral (mental)
At what levels of the EDSS will the pt be able to amb s an AD?
<6
What are the disease modifiers of MS
Fatigue
Heat
Stress
Trauma (mental or physical)
Infection
What are the signs associated with better prognosis in MS?
Female
<35y/o
small area of involvement
complete recovery p attacks
lower lesion burden on MRI
No brainstem/cerebellar involvement
Neurologic finding 5year post dx
What happens to NCV (nerve conduction velocity in MS?
decreases
Explain the immune response
antigen-->APC-->T-cell-->CD 4+8

CD4--> cytokines--> recruit beta cells -->create IgG

CD8-->release cytokines to kill
Explain theories of how neurons are destroyed.
immune cells attack myelin +/- oligodenrocytes --> cells become demyelinated -->gliosis occurs
What system reviews would you preform?
Neuromuscular
Musculoskeletal
Cardiopulm
Integumentary