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32 Cards in this Set
- Front
- Back
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artery dominant tone and ganglionic block effect
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sympathetic, relax SM, cause dilation and HTN
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veins dominant tone and ganglionic block effect
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sympathetic, dilation, pooling of blood, decrease VR, CO
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heart dominant tone and ganglionic block effect
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PS; increase HR
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bladder dominant tone and ganglionic block effect
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PS; urinary retention
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GI dominant tone and ganglionic block effect
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PS; decrease digestion, cause constipation
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Iris dominant tone and ganglionic block effect
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PS; mydriasis
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H1, A1, V1, M1, M3 protein class
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Gq
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B1, B2, D1, H2, V2
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Gs
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M2, A2, D2
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Gi
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A1
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increase vascular smooth muscle contraction
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A2
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decrease sympathetic outflow, decrease insulin
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B1
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increase HR, contractility, renin release, lipolysis, aq humor formation
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B2
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vasodilation, bronchodilation, increase glucagon release
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M1
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CNS
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M2
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decrease HR
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M3
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increase exocrine gland secretions
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D1
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relaxes renal venular SM
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what blocks choline reentry into cell
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hemicholinium
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what makes ACH
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ACoA plus choline via ChAT
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what inhibits ChAT
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veasmicol
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what causes ACh release?
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black widow toxin, Ca
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what inhibits ACh release?
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botulinum, causes flaccid paralysis
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4 fates of ACh
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bind to Ach receptor, bind to Ach autoreceptor, degrade by AChEsterase, diffuse away
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what is rate limiting step in ACh synthesis
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choline going back into the cell
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what blocks tyrosine--> dopa?
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metryosine
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enzyme metryosine acts on
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tyrosine hydroxylase (rate limiting step in NE synthesis)
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what blocks dopamine being packaged into NE vessels?
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reserpine
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what causes NE release?
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amphetamine, ephedrine, tyramine
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what blocks NE release?
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guanethidine, bretyllium
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what autoreceptors are involved in NE release?
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M1, A2 (inhibitory)
AT II (stimulatory) |
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what inhibits NE reuptake?
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cocaine, TCA
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what are the 4 fates of NE?
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reuptake, bind to postsyn receptor, bind to autoreceptor, metabolized/diffused by COMT, MAO
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