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32 Cards in this Set

  • Front
  • Back
artery dominant tone and ganglionic block effect
sympathetic, relax SM, cause dilation and HTN
veins dominant tone and ganglionic block effect
sympathetic, dilation, pooling of blood, decrease VR, CO
heart dominant tone and ganglionic block effect
PS; increase HR
bladder dominant tone and ganglionic block effect
PS; urinary retention
GI dominant tone and ganglionic block effect
PS; decrease digestion, cause constipation
Iris dominant tone and ganglionic block effect
PS; mydriasis
H1, A1, V1, M1, M3 protein class
Gq
B1, B2, D1, H2, V2
Gs
M2, A2, D2
Gi
A1
increase vascular smooth muscle contraction
A2
decrease sympathetic outflow, decrease insulin
B1
increase HR, contractility, renin release, lipolysis, aq humor formation
B2
vasodilation, bronchodilation, increase glucagon release
M1
CNS
M2
decrease HR
M3
increase exocrine gland secretions
D1
relaxes renal venular SM
what blocks choline reentry into cell
hemicholinium
what makes ACH
ACoA plus choline via ChAT
what inhibits ChAT
veasmicol
what causes ACh release?
black widow toxin, Ca
what inhibits ACh release?
botulinum, causes flaccid paralysis
4 fates of ACh
bind to Ach receptor, bind to Ach autoreceptor, degrade by AChEsterase, diffuse away
what is rate limiting step in ACh synthesis
choline going back into the cell
what blocks tyrosine--> dopa?
metryosine
enzyme metryosine acts on
tyrosine hydroxylase (rate limiting step in NE synthesis)
what blocks dopamine being packaged into NE vessels?
reserpine
what causes NE release?
amphetamine, ephedrine, tyramine
what blocks NE release?
guanethidine, bretyllium
what autoreceptors are involved in NE release?
M1, A2 (inhibitory)
AT II (stimulatory)
what inhibits NE reuptake?
cocaine, TCA
what are the 4 fates of NE?
reuptake, bind to postsyn receptor, bind to autoreceptor, metabolized/diffused by COMT, MAO